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Biomedical subjects

M Ravid

Publications and source records attributed to M Ravid.

170 records · Page 10Linked to original sources
PubMedDate not supplied

Adverse reactions to prolonged treatment with high doses of carbenicillin and ureidopenicillins.

Charts were reviewed for 63 patients whose chronic pseudomonas osteomyelitis was treated with high doses of extended-spectrum penicillins for prolonged periods. The incidence of untoward drug reactions was significantly higher than expected. Carbenicillin evoked adverse reactions in 22.8% of patients. However, most of these reactions were mild, and a change of drug was required in only 5.7% of cases. No adverse drug reactions were observed with cumulative doses of less than 750 g. In contrast to carbenicillin, the ureidopenicillins were associated with adverse reactions in 67.7% of patients; most reactions were moderate to severe in intensity; a cumulative dose of greater than 250 g produced adverse reactions; and discontinuation or change of therapy was required in 51.6% of cases. The main adverse reactions to both carbenicillin and the ureidopenicillins included rash, drug fever, leukopenia, eosinophilia, thrombocytopenia, and hepatic damage.

Adult↗
PubMedDate not supplied

Fulminant cutaneous T-cell lymphoma and Sézary syndrome.

The term cutaneous T-cell lymphoma (CTCL) has recently been coined to describe a group of rare lymphoproliferative T-cell disorders classically beginning in the skin and pursuing a chronic, progressive, and indolent course eventually followed by visceral involvement. This term encompasses the spectrum of the traditional mycosis fungoides and Sézary syndrome. A unique case of CTCL that developed a fulminant course leading to death within a few months following the initial symptoms is presented. The clinical course bears a striking similarity to a group of acute T-cell malignancies, while the cytologic-pathologic findings favor the diagnosis of Sézary syndrome. Regardless of the exact classifications, this entity appears to be a highly malignant T-cell disorder, resistant to chemotherapy.

Adult↗
PubMedDate not supplied

Fine needle aspiration biopsy in patients with diffusely enlarged spleens.

OBJECTIVE: To evaluate the diagnostic value and potential risk of fine needle aspiration biopsy (FNAB) of the spleen in patients with diffuse splenomegaly due to an undetermined cause. STUDY DESIGN: Retrospective evaluation of the medical records and cytologic material from 58 patients on whom FNAB was performed between 1967 and 1993. RESULTS: Sixty-five FNABs were performed on 58 patients. Lymphoproliferative diseases were found in six; in four additional cases, metastatic adenocarcinoma, sarcoidosis, Candida albicans and enterococcal infection were demonstrated. The remaining 55 biopsies either showed normal splenic tissue or were nondiagnostic. No complications were recorded. CONCLUSION: Splenic FNAB may be useful in some patients with diffuse splenomegaly. The diagnostic yield is rather low. The procedure, however, is simple, safe and well tolerated.

Adolescent↗
PubMedDate not supplied

Computed tomographic demonstration of choanal atresia.

During a 3-year period, nine girls and two boys (age range, 2 days-13 years) with congenital choanal atresia were evaluated by computed tomography (CT). Other associated congenital anomalies, primarily craniofacial anomalies, were present in six of the 11 patients. In six patients the atresia was bilateral and consisted of both bony and membranous components. Of the five patients with unilateral atresia, the lesions were on the right in three and on the left in two. CT demonstrated the atresia, choanal stenosis, septal deviation, and thickening of the vomer and palatine bone. The ease of CT examination and the high accuracy of the results make it the preferred imaging method for evaluating choanal atresia.

Adolescent↗