Giant congenital nevus as a basis for the development of malignant melanoma.
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Biomedical subjects
Publications and source records attributed to M Pruszczynski.
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Clinical and histopathological findings in a group of 28 infants suffering from retinoblastoma were analyzed. The authors were able to demonstrate that the retinoblastomas occurred considerably more often in the left eye than in the right. In children whose average age was under 2 years tumors found in the left eye were more differentiated. The authors point out that nephroblastomas (Wilm's tumor), like retinoblastomas, occur more frequently in the left eye and have a better prognosis in patients under 2 years of age.
Endolaryngeal synovial sarcoma has only been reported in the literature three times. We add to this a fourth report of a 28-year-old woman. This case distinguishes itself by being a monophasic variant and by being the first to be substantiated with extensive immunohistochemical analysis. Treatment consisted of shelling-out followed by radiotherapy, which is a variant from standard therapy. The patient is tumor-free 3 years after therapy.
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Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVIII:RAg) and Ulex europaeus agglutinin I. The coexpression of polyclonal cytokeratin and FVIII:RAg was demonstrated by means of step sections in the same tumor cells. The endothelial origin of epithelioid tumor cells was supported ultrastructurally by identification of Weibel-Palade bodies.
The symptomatology of a typical acute descending thoracic aorta dissection was imitated by profuse haemorrhage caused by a benign tumour composed almost exclusively of Wagner-Meissner like tactile corpuscles and fatty tissue. The tumour caused extensive destruction of the bodies of the fifth and sixth thoracic vertebrae at the level of the vertebro-costal articulation. Emergency cross clamping of the descending aorta and haemostasis of the bleeding from osteal defects by tamponade with bone polymethyl methacrylate appeared the only way to control the life threatening haemorrhage. It seems that an intrathoracic tactile neurofibroma with a similar case history has not been reported till now.