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Biomedical subjects

M Picard

Publications and source records attributed to M Picard.

151 records · Page 9Linked to original sources
PubMedDate not supplied

Speech audiometry in noise-exposed workers: the SRT-PTA relationship revisited.

The speech recognition threshold (SRT) is believed to be related primarily to the pure-tone average (PTA) and the steepness of the hearing loss. However, there are indications that it may also be influenced by perceptual or cognitive-linguistic factors, or both, such as meaningfulness of the speech stimuli. The purpose of the present study was to ascertain the correspondence between SRT and PTA in noise-exposed workers with various degrees of speech recognition threshold shift in noise. To this end, a total of 807 SRTs and PTAs collected from fluent speakers of Quebec French noise-exposed workers were compared. Measurements of context effects on speech recognition were taken based on a general hypothesis that they should be facilitating phoneme or word restoration in conditions of high stimulus uncertainty as present in SRT assessment, thus acting to confound the SRT PTA relationship. Using principal components analysis, we found a significant effect not only of low-frequency hearing sensitivity but language context effects on SRT. After a correction was introduced to partial out these linguistic context effects, correlations between SRT and PTA increased but they were lower than predicted. In a related treatment analysis, we found a large number of observations (230 out of 807) where SRTs were more sensitive than PTAs by a factor of 8 to 16 dB. This was the case even though correlations between the two measurements were within the range commonly advocated in the field of clinical audiology (0.85-0.95). This was interpreted as a sign of phonological and lexical context effects on the speech recognition task actually used by individual subjects to facilitate speech understanding, to the point perhaps of making it as simple as the detection of pure tones.

Adult↗
PubMedDate not supplied

Antibody responses of hens fed vitamin E and passively acquired antibodies of their chicks.

Antibody responses of hens and their progeny were studied in commercial broiler nuclear lines. Starting at 168 days of age, individually housed pullets from lines A and B were fed a 16% crude protein and 2752 kcal metabolizable energy/kg mash diet supplemented with either 10 or 300 IU/kg of vitamin E fed as dl-alpha-tocopherol acetate. Fifty-eight days later (226 days of age), 12 hens per line-vitamin E subclass were inoculated i.v. with 0.1 ml of a 2.5% suspension of sheep red blood cells (SRBC). Plasma antibody titers were measured 6, 20, 40, 54, 70, and 88 days after inoculation. Hens from both lines were artificially mated to males from line C, and progeny from eggs collected 9-15, 25-30, and 65-70 days after inoculation were tested for antibodies to SRBC. Hens were reinoculated i.v. with 0.1 ml of 0.25% SRBC 88 days after the first inoculation, and their antibody levels were measured 3, 6, and 20 days later. Eggs laid 10-13 days after reinoculation were incubated, and antibody titers of chicks were measured at hatch. Antibody response of hens to an initial inoculation of SRBC was line-diet-time after inoculation specific. In line A, titers were greater for hens fed the lower than the higher vitamin E diet, whereas diet had no effect on the antibody levels in line B. Line effects (A > B) were observed on days 6 and 20 after inoculation but not thereafter. After the second inoculation, dietary vitamin E level had no effect on antibody levels of hens within lines, whereas a between-line difference (A > B) was observed for the lower but not the higher level of dietary vitamin E. Although there was no difference between diets for antibody transferred to progeny by line B, there was a difference (lower > higher) for line A. After reinoculation of their dams, antibody titers of chicks from line A, but not line B, reached levels similar to those after the first inoculation. Antibody levels were higher for chicks at hatch than in 16-day embryos or 10 days posthatch. The results of this research suggest genetic variation in response to immune stimulation by dietary vitamin E.

Animal Feed↗
PubMedDate not supplied

Revisiting speech interference in classrooms.

A review of the effects of ambient noise and reverberation on speech intelligibility in classrooms has been completed because of the long-standing lack of agreement on preferred acoustical criteria for unconstrained speech accessibility and communication in educational facilities. An overwhelming body of evidence has been collected to suggest that noise levels in particular are usually far in excess of any reasonable prescription for optimal conditions for understanding speech in classrooms. Quite surprisingly, poor classroom acoustics seem to be the prevailing condition for both normally-hearing and hearing-impaired students with reported A-weighted ambient noise levels 4-37 dB above values currently agreed upon to provide optimal understanding. Revision of currently proposed room acoustic performance criteria to ensure speech accessibility for all students indicates the need for a guideline weighted for age and one for more vulnerable groups. For teens (12-year-olds and older) and young adults having normal speech processing in noise, ambient noise levels not exceeding 40 dBA are suggested as acceptable, and reverberation times of about 0.5 s are concluded to be optimum. Younger students, having normal speech processing in noise for their age, would require noise levels ranging from 39 dBA for 10-11-year-olds to only 28.5 dBA for 6-7-year-olds. By contrast, groups suspected of delayed speech processing in noise may require levels as low as only 21.5 dBA at age 6-7. As one would expect, these more vulnerable students would include the hearing-impaired in the course of language development and non-native listeners.

Acoustics↗
PubMedDate not supplied

Familial resemblance of bone mineral density between females 18 years and older and their mothers.

Potential determinants of bone mass were investigated in a group of 70 young females (mean age 26.6 years), daughters of women studied in premenopause. Nutritional data, leisure physical activity level, lifestyle habits as well as familial similarities were assessed. The daughters' bone mineral density (BMD), measured by dual-energy absorptiometry, was significantly correlated with their body mass index (BMI) (r = 0.22), dietary vitamin D intake (r = 0.19) and their mothers' BMD (r = 0.44). Multiple regression analysis indicated that only the mothers' BMD remained an independent predictor of bone mass. Mother-daughter correlations were also observed for body weight (r = 0.24), height (r = 0.39), BMI (r = 0.29), dietary calcium intake (r = 0.20), and calcium (r = 0.20) or vitamin D (r = 0.25) intakes from dairy products. Hence, these observations support the evidence that mothers' BMD is the strongest predictor of bone mass of young women in their third decade.

Adult↗