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Biomedical subjects

M Parent

Publications and source records attributed to M Parent.

At least 91 records · Page 5Linked to original sources
PubMed1986

[Isolated spinal cord involvement. Recurrence of sarcoidosis].

Three months after having stopped a corticosteroid therapy prescribed for disseminated sarcoidosis, a 23 year-old man presented signs of thoracic spinal cord involvement, with a lymphocytic reaction in the CSF. The hypothesis of a recurrence of sarcoidosis was evoked, and, after a few days course of corticosteroid, the patient recovered; he had no functional sequelae, and did not present any recurrence 2 years after having stopped the treatment. The main characteristics of spinal cord sarcoidosis are summarized: occurrence during a usually previously known sarcoidosis, within weeks or months, located spinal cord involvement, sometimes with a syringomyelic syndrome, and lymphocytic CSF reaction. In this case, the lesion was probably an arachnoidal infiltration without tumorous process of the spinal cord. Corticosteroid must be prescribed at once, and for a long time, because the results of surgery are always poor.

Adult↗
PubMed1984

[Cerebral abscesses disclosing pulmonary angioma. Rendu-Osler disease].

A 50-year old male patient presented with two successive cerebral abscesses over a 9-month period. Rendu-Osler-Weber disease was diagnosed on the basis of recurrent epistaxis and telangiectasis of the mucosae and skin. In addition, many members of the patient's family had a history of epistaxis and one had a cerebral angioma of unusual location. Our patient's chest was normal on physical and radiological examination, but pulmonary angiography disclosed a small angioma. Removal of the angioma prevented further cerebral infections. The prevalence of pulmonary arterio-venous fistulae in Rendu-Osler-Weber disease and their clinical manifestations (especially in the central nervous system) are reviewed, together with the value of family studies and the therapeutic approach.

Brain Abscess↗
PubMed1984

[Myositis disclosing systemic scleroderma].

A 61 year old patient presented with muscular atrophy and weakness, predominant at the shoulder girdle, as the first manifestation of a progressive systemic sclerosis with the signs of the CREST syndrome: subcutaneous calcinosis, Raynaud phenomenon, esophagus disorders, sclerodactyly, telangiectasia. The histological features were consistent with polymyositis. In spite of corticotherapy, total recovery was not obtained. The nosological relationships with Mixed Connective Tissue Disease is discussed. Myositis is infrequent in progressive systemic sclerosis and corticosteroid therapy is discussed.

Calcinosis↗
PubMed1983

Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children.

The accuracy of signs and symptoms as predictors of the presence and severity of esophageal injury was evaluated in 378 children admitted to three pediatric hospitals between 1970 and 1980. The signs and symptoms analyzed included nausea, vomiting, dysphagia, refusal to drink, abdominal pain, increased salivation, oropharyngeal burns, and abdominal tenderness. The severity of lesions found at esophagoscopy in 378 children was graded from grade 0, no lesion, to grade 3, perforation. Of the 298 patients demonstrating signs or symptoms, 243 (82%) had a grade 0 or 1 lesion, 55 (18%) had a grade 2 lesion, none had a grade 3 lesion, and five (2%) developed a stricture of the esophagus. Among the 80 patients without signs or symptoms, 70 (88%) had a grade 0 or 1 lesion, ten (12%) had a grade 2 lesion, none had a grade 3 lesion, and one (1%) developed a stricture of the esophagus. When individual signs or symptoms were correlated with the severity of esophageal lesion, vomiting (33%) followed by dysphagia (25%), excessive salivation (24%), and abdominal pain (24%) were most frequently associated with a grade 2 or 3 esophageal lesion. A similar percentage of a grade 0 or 1 (82% v 85%), a grade 2 (18% v 15%), and a grade 3 (0%) esophageal lesion followed the ingestion, respectively, of an alkali (324 patients) or an acid (54 patients). In six patients (2%) stricture occurred only following an alkali ingestion. These data demonstrate that signs and/or symptoms do not adequately predict the presence or severity of an esophageal lesion following the ingestion of a caustic substance.

Abdomen↗
PubMed1983

Flupenthixol versus haloperidol in acute psychosis.

Forty acutely psychotic patients were treated either with flupenthixol drops or haloperidol drops in an open, 28-day controlled study. The flupenthixol group comprised 11 schizophrenic, 8 manic, and 1 paranoid patient and there were 10 schizophrenic, 5 manic, and 5 paranoid patients in the haloperidol group. Mean daily dosage was approximately 112 mg flupenthixol and 18 mg haloperidol. Clinically, both drugs showed an antipsychotic effect. In the schizophrenic patients there was a definite trend towards a more rapid relief of the psychotic symptoms after flupenthixol treatment. In contrast to haloperidol, flupenthixol showed a mood elevating effect and an effect on the negative symptoms, e.g. emotional withdrawal, motor retardation, blunted affect, and disorientation. With both drugs, the most troublesome side-effects were extrapyramidal in nature. Initially, they were more common in the flupenthixol group: later the incidence was similar.

Acute Disease↗
PubMed1982

Protein and taurine of maternal diets during the mouse neonatal period: permanent effects on cerebellar--brainstem amino acid levels in mature offspring.

Neonatal malnutrition and/or undernutrition of limited duration appears to permanently influence steady state amino acid content of the adult mouse cerebellum and/or brainstem. Some of the changes seem related to the protein content of the milk (glutamine), whereas others reflect the taurine concentration in the milk during the neonatal period (glutamic acid and GABA). Adult levels of taurine, serine, and glycine in the cerebellum-brainstem may in part be influenced by the degree of growth retardation which occurred during the first 16 days of neonatal life. Provided the combined adult weight of the cerebellum and brainstem can be used as one criterion to determine growth retardation during the neonatal period, it appears justified to state that mice do not recover from malnutrition/undernutrition when subjected to such conditions during early infancy.

Aging↗
PubMed1982

[Flupenthixol versus haloperidol in acute psychotic episodes].

The aim of this study is to evaluate the activity of flupentixol oral high concentration and to define the profile of the drug according to the administered dose. The trial includes 40 acute patients (21 schizophrenics, 13 manic patients and 6 other psychotics). The study was open, but the patients were treated at random either by haloperidol or by flupentixol. Both substances showed a strong antipsychotic and antimanic effect. The differences according to the administered doses were: a quicker onset of action for flupentixol in schizophrenic patients; a more pronounced activity of flupentixol in the same patients, as far as anxiety, depressive tendencies and defect symptoms are concerned. Extrapyramidal side effects are the most common ones amongst the two drugs.

Acute Disease↗
PubMed1981

Effect of protein and taurine content of maternal diet on the physical development of neonates.

The effect of taurine and/or protein composition of maternal diets was examined for effects on survival rates and growth of neonates. Most of the effects observed are attributable to the influence of such diets on both the quantity and quality of the milk supplied to the neonates. The taurine and protein content of the diets exhibit an interdependent relationship with respect to regulating the protein and taurine concentration of the milk. The overall effect of dietary taurine was to increase neonatal survival during the period that the mothers received a protein-deficient diet.

Animals↗
PubMed1981

[Kehr's drainage].

Explore the source record for details and available documents.

Cholelithiasis↗
PubMed1977

Droperidol in acutely agitated patients. A double-blind placebo-controlled study.

Forty-one acutely agitated patients received an i.v. injection of 4 ml of a double blind solution containing either 10 mg of droperidol or placebo. The need for further medication (5 mg of haloperidol after 3 minutes or individually adapted psychotropics after 30 minutes) was used as a parameter for the evaluation of the results. Three minutes after the injection, haloperidol was needed by only six out of 19 patients of the droperidol group, but by 19 patients of the control group. Thirty minutes after the first injection, further medication was needed by only four droperidol patients and 10 placebo patients. No side effects could be attributed to the double blind medication.

Acute Disease↗