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Biomedical subjects

M Palutke

Publications and source records attributed to M Palutke.

47 records · Page 3Linked to original sources
PubMed1977

T cell leukemia--lymphoma in young adults.

The clinical, pathologic, immunologic and electron microscopic findings in three cases of young men who had T cell leukemia and lymphoma are presented. The disease in this older age group appears to have the same characteristics as that seen in children. It is an aggressive, rapidly fatal disease with a poor response to the usual chemotherapeutic regimens for acute leukemia or poorly differentiated lymphocytic lymphoma, with which this T cell disorder is frequently grouped. An example of Burkitt's lymphoma in another young man is presented briefly to illustrate the clinical, morphologic and immunologic similarities to and differences from an aggressive B cell lymphoma.

Adolescent↗
PubMed1975

T-cell lymphoma. Report of a case.

The morphologic, immunologic, and clinical findings in the case of a patient with a T-cell mediastinal lymphoma ((Sternberg sarcoma) are presented.

Adolescent↗
PubMed1975

In vitro effect of methylprednisolone on protein synthesis of activated canine thymus-derived lymphocytes.

Technics of studying the protein synthesis of canine thymus-derived lymphocytes in vitro have been developed. Activation of these cells by PHA or MLC increases protein synthesis. Methylprednisolone decreases the stimulation of protein synthesis of these activated lymphocytes. The decrease in protein synthesis is not caused by lympholysis. In this respect, the dog, like man, can be considered a steroid-resistant animal. It is postulated that this effect of methylprednisolone contributes to its immunosuppressive action by inhibiting the afferent limb of the immune response.

Animals↗
PubMedDate not supplied

Red cell hypoplasia and monoclonal gammopathy in a patient with lymphoproliferative disorder.

A 69-year-old male was observed to have red cell hypoplasia. Two years later monoclonal gammopathy IgG-I, K, Gma+ and InV (1-) was documented in this patient. Persistent lymphocytosis, abnormal response to phytohemagglutinin, and at autopsy multiple lymphoid nodules occurring in the bone marrow, suggestive of lymphoproliferative disorder, were observed. A review of the literature indicates that this clinical presentation is rare. The possibility that red cell aplasia may be associated with lymphoproliferative disorder in some instances must be considered inasmuch as this may have an important bearing in the management of such patients.

Aged↗
PubMedDate not supplied

Cytochemical and immunological aspects of the acute lymphocytic leukemias (as related to FAB classification).

The FAB classification of acute leukemias was proposed by a cooperative French-American-British group as an easily applied classification useful for uniform assessment of large clinical therapeutic trials. Although the classification is based on morphological criteria, cytochemical, biochemical, immunological and cytogenetic studies supplement the morphologic criteria for accurate identification of the leukemic blasts. The FAB criteria are shown by these supplementary studies to be deficient for classifying the acute lymphocytic leukemias (ALL) since various subgroups of ALL appear in more than one FAB group. Precise definitions of clinical-pathological entities within the framework of the FAB classification are desirable.

Cytogenetics↗