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Biomedical subjects

M P David

Publications and source records attributed to M P David.

At least 127 records · Page 7Linked to original sources
PubMed1983

Acceleration of wound healing by topical application of honey. An animal model.

Commercial unboiled honey was applied topically to open wounds of 12 mice. Twelve other mice served as a control group and their wounds were dressed with saline solution only. Wound healing was judged histopathologically by measuring the thickness of granulation tissue, epithelization from the periphery of the wound, and the size of the open wounds. The animals were killed 3, 6, and 9 days from the day they were wounded and treated, and their wounds were examined histopathologically. According to the three mentioned criteria, wounds of the honey-treated animals healed much faster than the wounds of the control animals (p less than 0.001). Unboiled commercial honey seems to accelerate wound healing when applied topically due to its energy-producing properties, its hygroscopic effect on the wound, and its bacteriocidic properties. Our results suggest that honey applied topically on open wounds accelerates the healing process.

Administration, Topical↗
PubMed1983

Comparison between OM-GA Cu and Copper-T IUCDs.

OM-GA Cu and Copper-T IUCDs were compared in a randomized prospective clinical trial in two-hundred women and followed up for two years. Dysmenorrhea and dyspareunia were more frequent with the Copper-T. Menometrorrhagiae, vaginal discharge and pelvic inflammatory disease were similar with both IUCDs. Two-year pregnancy rate for the OM-GA Cu was 5.4% and 3.2% for the Copper-T. Expulsion rate was 11.9% for the OM-GA Cu and 5.3% for the Copper-T. The OM-GA Cu users had less dysmenorrhea and dyspareunia but a higher expulsion rate compared to the Copper-T.

Adult↗
PubMed1983

The peritoneal reaction to the translocated copper intrauterine device in women and female rats.

The observation of a very severe peritoneal reaction to translocated copper-bearing devices in five women necessitated operative removal. Three Copper-T (Ortho Gyne-T, Ortho, Saunderton, High Wycombe, England) and two Copper-7 (Gravigard, Searle, High Wycombe, England) devices were involved. Similarly severe peritoneal reactions were noted in 90% of female rats who had small-sized modified copper devices inserted into their peritoneal cavities. In a control group of rats with the same device but without a copper wire, mild adhesions were observed in the majority (85%), and none had a severe peritoneal reaction. It seems evident that the severe peritoneal reaction is induced by the copper wire in both women and female rats.

Animals↗
PubMed1983

Establishment of a method for preservation of human cervical mucus for in vitro penetration tests.

Midcycle cervical mucus was obtained from 56 women. Each mucus sample was divided into four portions collected into a capillary tube and kept either at room temperature or at 4 degrees C, -20 degrees C or in liquid nitrogen for 1 h, afterwards thawed at 37 degrees C and used in the in vitro penetration device for 1 h. 56 semen samples of good quality were used, the same sample for all four types of the same cervical mucus. Very high significant correlations were calculated between the penetration value (PV) rates in all four methods of cervical mucus preservation. Paired t test revealed a significant decrease (p less than 0.025) in the PV rates of sperm in the cervical mucus cryopreserved in liquid nitrogen. The results of this study recommend the establishment of a cervical mucus bank using the 4 degrees C and -20 degrees C as possible methods for preservation of cervical mucus.

Cervix Mucus↗
PubMed1983

Variations in the effect of epidural morphine in gynecological and obstetric patients.

A prospective study was performed on the effect of epidural morphine (2 mg in 10 ml of saline) in three groups of patients: (1) following gynecological operations, 60; (2) following cesarean section, 120; (3) patients in active labor, 30. Pain relief in the first group was uniformly and almost invariably complete for up to 24 hours. In the second group spasmodic visceral pain was felt after about 10 hours, relieved by light analgesics. The wound was not painful. In the third group only hypoalgesia was obtained during labor, but if an episiotomy was done, the pain in the perineum was relieved. Few side effects were observed: urinary retention, vomiting, and non-segmental itching. Neither motor nor sympathetic block were noted. The somatic effect of epidural morphine was reliable and uniform, whereas visceral pain was poorly affected. The side effects cause relatively little disturbance at the dose used.

Adult↗
PubMed1982

Fetal distress due to intravenous administration of pethidine (meperidine) with promethazine during labour.

Fetal bradycardia due to uterine hypertonia was observed after the intravenous administration of pethidine (meperidine) 75 mg with promethazine 25 mg during active labour. These analgesic drugs are known to affect uterine contractions by enhancing both amplitude and frequency, but are thought to affect uterine tone minimally. Twenty cases of uterine hypertonia resulting in fetal bradycardia were monitored in a period of 6 months in women receiving these drugs during labour. In all cases, the uterine hypertonia appeared shortly after the drug administration. The uterine hypertonus as well as the fetal bradycardia were self limited and no intervention was undertaken. Recognition of this phenomenon is important in order to prevent unnecessary anxiety on the part of medical attendants.

Bradycardia↗
PubMed1982

Human sperm penetration into cervical mucus in vitro: correlation between its quality, penetration capacity and velocity.

In vitro penetration tests of human sperm into cervical mucus were introduced in order to study the interaction between sperm and cervical mucus. In the present study the correlation between sperm velocity and penetration value has been assessed. 197 semen samples were run in the in vitro penetration test using semen of different qualities and cervical mucus of good quality. No differences were found either between sperm velocity in cervical mucus (17.3 +/- 0.9 micrometers/s) and in semen (19.9 +/- 0.8 micrometers/s) or at different distances measured along the flat capillary tube (1, 2 and 3 cm). A highly significant correlation was found between sperm velocity and penetration value rates (p less than 0.0001, r = 0.9). Thus, sperm velocity in semen is a variable of great importance in the assessment of the quality of the ejaculate.

Cervix Mucus↗
PubMed1982

Penetration of human ejaculated spermatozoa into human and bovine cervical mucus. II. Pattern and velocity of penetration.

The pattern of penetration of human ejaculated spermatozoa into human cervical mucus (HCM) and bovine cervical mucus (BCM) was studied in an in vitro penetration system by means of plate capillary tubes. Sperm penetrate the HCM in a unique pattern making their way progressively forwards in a one-way direction in between the filaments. In contrast, sperm move preferably forward in BCM. The different patterns are probably due to different organizations of the glycoproteins. The penetration values (PV) were also different in the two systems when studied after short periods of incubation (15 and 30 min), but incubation for 1 h brought both systems to the same rate of PV. Thus, this period is enough to overcome the differences between the patterns of penetration. Sperm velocity in semen, in HCM, and in BCM were the same. Cervical mucus (CM) did not affect sperm velocity. A strong correlation (r = 0.8) was found between sperm velocity in the semen and its PV rate either in HCM or in BCM. The results of this study recommend the use of BCM as a reference CM in cross penetration tests and suggest its establishment as a routine method for assessment of sperm quality.

Animals↗
PubMed1981

Tubal intramural polyps and their relationship to infertility.

In a search for polyps in the intramural portion of the fallopian tubes, 2156 hysterosalpingograms were reviewed. In 54 cases polyps of different size and form were detected. Correlation of the findings with fertility histories and follow-up revealed that about one-half (46%) of the women with polyps did not conceive. Among both women who conceived and those who did not were women who had been treated for some other cause of infertility and also women of infertile couples who were classified as infertile normal. The results of this study suggest that women with tubal polyps should be regarded as having relative subfertility and should be treated for other causes of infertility if such exist. However, when treatment fails, and also in cases of unexplained infertility, the polyps should be regarded as a possible causal factor and surgical treatment should be considered.

Fallopian Tube Neoplasms↗
PubMed1981

Penetration of human ejaculated spermatozoa into human and bovine cervical mucus. I. Correlation between penetration values.

Midcycle bovine cervical mucus (BCM), fresh (FBCM) or frozen at -20 degrees C (BCMF), and human cervical mucus (HCM) were collected and tested in in vitro penetration tests, using human ejaculated spermatozoa of good quality. Penetration tests were performed at 34 degrees C for 1 hour, and the penetration value (PV) was calculated. Duplicates of each run were in a narrow deviation. Correlations between PV rates of the same semen samples in the 3 sources were found to be significantly high (HCM versus FBCM, r = 0.958; HCM versus BCMF, r = 0.982, and FBCM versus BCMF, r = 0.985), suggesting that human ejaculated spermatozoa penetrate the cervical mucus of all three sources at the same rate.

Animals↗
PubMed1981

Filtering capacity of bovine cervical mucus towards abnormal forms of human-ejaculated spermatozoa.

The filtration capacity of bovine cervical mucus (BCM), fresh bovine cervical mucus (FBCM) or frozen and thawed bovine mucus (BCMF) was studied, using human-ejaculated spermatozoa in comparison with the properties of human cervical mucus (HCM). Thirty semen specimens of good quality were used in cervical mucus (CM) penetrations, using capillary tubes containing CM of 30 HCM, 77 FBCM and 77 BCMF samples. Spermiocytograms were carried out on semen and cervical mucus at 1st and 3rd centimeter of the capillary tube after one hour of incubation. Smears were stained by Papanicolaou and the patterns of seven forms of sperm cells (normal, tapering, macrocephals, microcephals, pinhead, neck pathology and amorphous cells) were counted on a total of 100 cells in each slide. A clear, highly significant (P less than 0.0001) selection of cells penetrating the CM has been shown, preventing certain abnormal forms from penetrating the CM (macrocephals, neck pathology and amorphous cells) and enabling good penetration of normal sperm forms and moderate penetration of tapering, microcephals and pinhead cells. On the average, a specimen with normal sperm forms of 72% showed a spermiocytogram of 90% normal forms at the 3rd centimeter of migration. The same patterns of filtration were recorded in all the three sources of CM. It is suggested that BCM be used as a filter towards abnormal sperm forms in a highly teratozoospermic ejaculate in order to improve its quality for artificial inseminations.

Animals↗