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Biomedical subjects

M Owen

Publications and source records attributed to M Owen.

162 records · Page 9Linked to original sources

The teacher as observer and experimenter in the modification of disputing and talking-out behaviors.

Disputing and talking-out behaviors of individual pupils and entire classroom groups in special education classes and regular classes from white middle-class areas and from all black poverty areas ranging from the first grade to junior high school were studied. The classroom teacher in each case acted as the experimenter and as an observer. Various means of recording behaviors were used and reliability of observation was checked by an outside observer, another teacher, a teacher-aide, a student, or by using a tape recorder. Observation sessions varied from 15 min to an entire school day. After baseline rates were obtained, extinction of inappropriate disputing or talking-out behaviors and reinforcement of appropriate behavior with teacher attention, praise and in some cases a desired classroom activity or a surprise at the end of the week brought a decrease in undesired verbalizations. A reversal of contingencies brought a return to high levels of inappropriate talking with a return to low levels when reinforcement for appropriate talking was reinstated. The experiments demonstrated that teachers in a variety of classroom settings could obtain reliable observational records and carry out experimental manipulations successfully using resources available in most schools.

Journal Article↗

Keys to managing oncology care.

Each year, more than 1 million Americans are diagnosed with some form of cancer. Although the term cancer includes more than 100 different diseases, half of all cancers can be successfully treated or cured if the disease is detected early and appropriate therapy is initiated and administered as scheduled with minimal interruptions and dose modifications. Because of higher cure rates and longer survival, the current approach is to view cancer as a chronic rather than terminal illness.

Case Management↗

Oncology reimbursement changes on the horizon.

Did anyone ever say being a case manager was simple? Today's rapidly changing health care environment definitely has altered that perspective. Now more than ever, the case manager must be aware of the latest clinical interventions for the population of patients he or she serves and the financial picture painted by a variety of reimbursement sources.

Case Management↗

No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia.

Several recent studies have suggested that expanded CAG repeats may contribute to the genetic transmission of bipolar disorder and schizophrenia. In all known disorders associated with expanded CAG repeats, the repeat sequence is translated into glutamine. Therefore the simplest hypothesis is that one or more proteins with expanded polyglutamine sequences are involved in the pathogenesis of bipolar disorder and schizophrenia. In order to examine this hypothesis, we have used an antibody against expanded polyglutamine sequences to examine Western blots prepared from lymphoblastoid cell lines of patients with schizophrenia and bipolar disorder. We also examined Western blots prepared from left frontal cortex tissue samples obtained from 11 schizophrenics post mortem. With the exception of the TATA-binding protein (TBP), we did not detect any proteins containing expanded polyglutamine sequences. Our data therefore suggest either that the expanded repeats which are associated with these disorders do not encode polyglutamine, or that they are within genes that are not expressed within the tissues investigated here.

Adult↗

No evidence for linkage between schizophrenia and eight microsatellite markers on chromosome 19.

We report the results of a linkage study of eight markers on chromosome 19 in a sample of 24 families multiply affected with schizophrenia and related psychoses. This study forms part of a systematic search of the entire genome using microsatellite markers spaced at 10-20 cM intervals. These data provide no evidence for the presence of a gene of major effect on chromosome 19 under the assumption of genetic homogeneity or heterogeneity. We have attempted to describe the extent to which this region has been excluded and demonstrate that while it is possible to exclude near-dominant and recessive models under the assumption that all families are linked to the same locus, power for exclusion falls away rapidly when incomplete penetrance and heterogeneity are invoked.

Chromosomes, Human, Pair 19↗

Coming unglued.

Explore the source record for details and available documents.

Adult↗