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Biomedical subjects

M Oimomi

Publications and source records attributed to M Oimomi.

At least 73 records · Page 4Linked to original sources
PubMed1986

Autonomic nervous function determined by changes of periflux blood flow in the aged.

The periflux blood flow (PBF) in fingers was determined by a periflux laser Doppler flowmeter (PLDF). The patterns of PBF responses to standing and Valsalva's maneuver were analyzed. The PBF responses in both loading tests were well correlated with the results of the conventional autonomic function test. It was, therefore, considered that our method would be useful for assessment of autonomic function. We practically investigated PBF responses in the two loading tests in three groups: young age group (10-39 years), middle age group (40-69 years) and old age group (70-89 years). The old age group showed significant decreases in both sympathetic and parasympathetic functions. It was indicated that this non-surgical and simple autonomic function test will be useful particularly in the elderly.

Adolescent↗
PubMed1986

Increased fructose-lysine of nail protein and blood glucose control in diabetic patients.

Furosine, which was formed by acid hydrolysis of fructose-lysine, was determined and used as an indicator of glycosylated protein. The diabetic patients had significantly higher fructose-lysine levels in finger nails than healthy subjects [10.8 +/- 4.6% (mean +/- S.D.) vs 4.2 +/- 1.1%]. The best correlation was found between the fructose-lysine value and the fasting blood glucose level determined 3 to 5 months before sampling nails in diabetics. These results suggest that the furosine derived from fructose-lysine in finger nails may become an indicator of blood glucose control during the past 3 to 5 months in diabetics.

Adult↗
PubMed1986

Age-related acceleration of glycation of tissue proteins in rats.

The Maillard reaction on proteins is a nonenzymatic glycosylation that is now termed glycation and produces a ketoamine linkage on the protein. The extent of this glycation was estimated by determining furosine (epsilon-N-(2-furoylmethyl)-L-lysine), which is derived from glycated lysine residues. Glycation of rat sciatic nerve and aorta increased with advancing age for up to 50 weeks and the high degree of glycation was maintained thereafter. The level of hemoglobin did not change significantly after 14 weeks. These results suggest that tissue glycation may increase with aging and may be involved in the mechanism of aging.

Aging↗
PubMed1986

Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.

A fast-moving abnormal hemoglobin found in a diabetic patient was identified as beta 140 (H18) Ala----Asp. It comprised about 40% of the total hemoglobin. The beta N-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate.

Blood Protein Electrophoresis↗
PubMed1985

Increased fructose-lysine of hair protein in diabetic patients.

Fructose-lysine, which is formed by binding glucose to lysine, is changed by acid hydrolysis into furosine. Furosine derived from fructose-lysine of hair was determined by high-performance liquid chromatography according to the method of Schleicher et al. Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with the stable components of hemoglobin A1 (HbA1) values. These results suggest that furosine, like HbA1, may become an indicator of past blood glucose control at any time in diabetic patients and be useful in investigating diabetic complications on the level of tissue.

Adult↗
PubMed1985

A specific method of glycosylated hemoglobin using furosine measurement.

In order to get an accurately specific determination of glycosylated hemoglobin (GHb-f), the furosine assay method, which can detect epsilon-amino-lysine-bound glucose, was investigated. A good correlation was found between GHb-f values obtained by this method and HbA1 values by conventional ion exchange column chromatography. It was, therefore, considered that this technique would be a new useful method for determining glycosylated hemoglobin.

Diabetes Mellitus↗
PubMed1985

Evaluation of periflux blood flow measurement in diabetic patients with autonomic neuropathy.

The periflux blood flow (PBF) response pattern in the fingertips determined with a periflux laser Doppler flowmeter was analyzed in a standing test in which the subject was instructed to stand up from the sitting position and in Valsalva's maneuver in which respiration was held for 10 s at the maximum inspiration, and indicators such as reaction time (RT), orthostatic dysreaction rate (ODR) and PBF decreasing velocity (PDV) were established for determining autonomic abnormality. RT and ODR were significantly correlated with the change in blood pressure and pulse rate, respectively, in the standing test, and PDV was significantly correlated with beat-to-beat variation. Abnormalities were found in about half of the diabetics in the standing test and Valsalva's maneuver. These results suggested that the analysis of PBF changes in the standing and Valsalva's tests may be an easy and useful approach for clinical examination of the autonomic nervous system.

Adult↗
PubMed1985

Determination of carbamylated plasma protein and its clinical application to renal failure.

We determined carbamylated plasma protein (CPP) according to the method of Hunninghake in patients with renal failure and normal subjects. CPP values were significantly higher in patients with renal failure than in normal subjects. In patients with renal failure, a significant correlation was found between CPP levels and blood urea nitrogen. Thus, CPP appears to be a new indicator of the status of renal failure, irrespective of hemodialysis.

Blood Urea Nitrogen↗