A case of a suprasellar epithelial cyst in a 48-year-old man is reported. The cyst was lined with two different types of stratified epithelium: one was two to three or more layers of squamous cells with overlying ciliated columnar cells and goblet cells at the surface and the other was tyical stratified squamous epithelial cells. The tumor was neither a pure Rathke's cleft cyst nor a typical craniopharyngioma but was considered essentially to be a craniopharyngioma with ciliated columnar cells and goblet cells. Thus it might be considered a mixed form of these two tumors. This case indicates the close relationship between craniopharyngiomas and Rathke's cleft cysts.

Autopsy↗

PubMed1980

Experimental transmission of human subacute spongiform encephalopathy to small rodents. I. Clinical and histological observations.

Experimental transmission of subacute spongiform encephalopathy from three human cases to small rodents is reported. The first case with atypical CJD with spongiform change, kuru plaques, and leukomalacia was transmitted directly to mice, rats, and guinea pigs and indirectly to hamsters and Mongolian gerbils through rats. From two other typical SSE cases the disease was also successfully transmitted; from he second case to mice and rats, and from the third case to guinea pigs. Brain showed the highest infectivity; the spleen, liver, blood, and cerebrospinal fluid of diseased animals were also infective. Intracerebral inoculation was the route for the fastest transmission, followed by intrathecal, intraperitoneal, submucosal, and subcutaneous routes. The incubation periods and clinical features were characteristic in each inoculated species and did not vary within several passages, except for the shortening of incubation period from the first to the second passage. Histologically, a marked spongy state and proliferation of astrocytes were observed in all diseased animals, though the distribution of the lesion was peculiar to each species. The severe lesion in the white matter in mice was similar to that seen in mice inoculated with scrapie and also to that seen in the first case.

Aged↗

PubMed1980

Experimental transmission of human subacute spongiform encephalopathy to small rodents. II. Ultrastructural study of spongy state in the gray and white matter.

Light and electron microscopic findings of spongy state in four species of small rodents, viz, mice, rats, Mongolian gerbils, and guinea pigs, are described. The spongy state existed in both gray and white matter; its intensity varied in each species, and in the gray matter corresponded to vacuoles within the neuropil. They were of two types; one was the true vacuoles within neurites, and the other was markedly swollen cell processes, some of which were also identified as neurites. In the white matter, the spongy state corresponded mainly to distension of the myelin sheaths, due to splitting of the major dense line or swelling of the inner loop, and partly to intra-axonal vacuoles. In mice before appearance of clinical symptoms, the vacuolation occurred first in the cerebral white matter 5 weeks after inoculation and in the cerebral cortex at 7 weeks. The occurrence and development of the vacuoles are discussed.

Animals↗

PubMed1980

On the condition and activities of Jeddah Endoscopy Center.

Present condition and activities of Jeddah Endoscopy Center managed in cooperation with Saudian and Japanese doctors are reported. Total number of patients examined are 1,183 cases; 73% of which were subjected to endoscopy and 27% were to fluoroscopy. With respect to the stomach diseases, gastric cancer and ulcer were found in 16% and 14.7%, respectively. On the other hand, high incidences of severe atrophic gastritis and haemorrhagic or erosive gastritis accounted totally 64.7% of all stomach diseases were noted. Out of 264 cases of duodenal diseases, duodenal ulcer was diagnosed in number of 202 cases (76%). The ratio between gastric and duodenal ulcer was, therefore, approximately 1:6. It was further noted that most of patients with esophagus cancer were found in males having the local habit of taking green tobacco. From the results obtained, discussions were made on the statistical differences of gastrointestinal diseases between Saudi Arabia and Japan.

Adolescent↗

PubMed1980

Nocardia farcinica as a pathogen of lung infection.

Explore the source record for details and available documents.

Aged↗