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Biomedical subjects

M Ohara

Publications and source records attributed to M Ohara.

At least 163 records · Page 9Linked to original sources
PubMed1980

Evaluation of selective bronchial suctioning in the adult.

In the present study, the highest success rate in suctioning of the left main bronchus was achieved when curved-tip catheters of both Portex (40%) (Portex Limited, Hythe, Kent, England) and Rüsch (50%) (Willy Rüsch Gmph & Co. KG, West-Germany) were inserted with the patient's head in the midline position. The second most successful rate in reaching the left main stem bronchus occurred when the head was turned to the right using straight catheters of both Portex (31%) and Rüsch (29%). The third but lesser success rate in suctioning the left main stem bronchus was achieved with the head turned to the right, using curved-tip catheters of both Portex (25%) and Rüsch (23%). the lowest success rate in suctioning the left main stem bronchus was with the head in the midline position using straight catheters of both Portex (19%) and Rüsch (15%). The possible factors which influence success or failure to introducing suction catheters into the bronchi selectively were discussed.

Bronchi↗
PubMed1980

Potentiation by dilazep on the negative inotropic effect of adenosine on guinea-pig atria.

1 Dilazep, a coronary dilator, has been reported to potentiate the negative inotropic and negative chronotropic responses of guinea-pig atria to adenosine. Studies were made on the mechanism of the potentiating action of dilazep with special reference to the degradation and uptake of adenosine. 2 The negative inotropic actions of adenosine and adenine nucleotides, such as ATP, ADP, AMP and cyclic AMP, on guinea-pig atria were selectively and dose-dependently augmented by dilazep at concentrations insufficient to produce any effect alone (0.01 to 1 microM). 3 Incubation of atrial tissue with 8.8 nM adenosine, containing 0.1 microCi of [3H]-adenosine, resulted in accumulation of [3H]-adenosine in the tissue; dilazep (0.01 to 1 microM) inhibited this accumulation. 4 Adenosine (10 microM to 10 mM) was degraded to inosine and hypoxanthine during incubation with atrial tissue; dilazep (0.1 to 10 microM) retarded the disappearance of adenosine and the formation of inosine and hypoxanthine. 5 These results suggest that dilazep potentiates the negative inotropic effect of adenosine on guinea-pig atria by preventing both its accumulation by atrial tissue and degradation by deaminase.

Adenosine↗
PubMed1979

Pregnancy-associated a2-glycoprotein in rheumatoid arthritis.

Pregnancy-associated alpha2-glycoprotein (PAG) was found to be increased in sera and synovial fluids of patients suffering from rheumatoid arthritis tested in the single radial immunodiffusion. The PAG levels in rheumatoid sera correlated well with the activity of arthritis in the patients. The purified PAG inhibited clearly the 3H-thymidine uptake of normal lymphocytes stimulated with phytohemagglutinin and also the spontaneous attachment of sheep erythrocytes to normal lymphocytes. 17 of 19 rheumatoid plasmas inhibited the 3H-thymidine uptake of normal lymphocytes and intensity of their inhibitory effects correlated with serum PAG levels.

Arthritis, Rheumatoid↗
PubMed1978

Potentiation by dipyridamole of the inhibition of guinea-pig ileum twitch response caused by adenine derivatives.

The inhibition actions of adenosine and adenine nucleotides, such as ATP, AMP and cyclic AMP, on contractions of guinea-pig from ileum induced by transmural stimulation were potentiated by dipyridamole, whereas those of inosine, morphine and tetrodotoxin were not affected. Tritium activity, accumulated during incubation of the ileal segments with [3H]adenosine, was reduced by dipyridamole. The adenosine added was degraded to inosine and then hypoxanthine during incubation, with the ileal segments, thereby restoring the twitch response of the ileal segments. In the presence of dipyridamole, the degradation of adenosine and the recovery of the twitch response was retarded. Thus, dipyridamole may potentiate the inhibitory actions of adenosine and adenine nucleotides on the twitch response of the ileum by inhibiting both the accumulation and the degradation of adenosine.

Adenine Nucleotides↗