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Biomedical subjects

M Ogata

Publications and source records attributed to M Ogata.

At least 541 records · Page 30Linked to original sources
PubMed1981

[Studies on the toxicity of toluene (author's transl)].

Toluene has been used widely as organic industrial solvent separately or together with other solvents. Many workers contact toluene resulting in acute and chronic poisonings. Problems studied include its acute and chronic epidemiology, toxicity on animals and human beings, dose-response relationships, fate in the living body (absorption, distribution, metabolism and excretion), maximum allowable concentration and biological monitoring limit value of this chemical. In this paper many recent reports of toxicity and metabolism of toluene are reviewed.

Adult↗
PubMed1981

Cytological and immunological examination of cerebrospinal fluid in 9 patients with Ramsay Hunt's syndrome.

The purpose of the present study was to carry out the immunological and cytological examination of cerebrospinal fluid in 9 patients with Ramsay Hunt's syndrome. The results obtained were as follows: Among the serum immunoglobulins, IgG in 1 and IgM in 5 of 9 cases increased. The Varicella Zoster antibody titer was significantly elevated in sera of all 9 cases and in CSF of all 7 examined cases. There ws positive fluorescence to Varicella Zoster virus in 2 (Cases 8 and 9) of 4 cases in which CSF smears were examined. The cells showing fluorescence were 10.5% in the former and 1.5% in the latter. Pleocytosis was found in all cases and CSF cell counts ranged from 52 to 2,000/3 mm3 in the early stage. In 3 cases immunoglobulin containing cells (IgG and IgM) were seen about 2-20% within 2 weeks of onset. IgG contents in all and IgG% in 8 of 9 cases, IgA concentration in 7 and IgA% in 7 of 9 cases were increased. These results support the view that the Varicella Zoster virus spreads to the meninges and CSF from ganglions in patients with Ramsay Hunt's syndromes.

Adult↗
PubMed1981

Quantitative determination of urinary metabolites in subjects exposed to organic solvents.

Most of the common organic solvents are excreted into urine as metabolites. A correlation exists for several organic solvents between the amount taken in and the amount of metabolites excreted. Many methods have been developed for the measurement of these urinary metabolites. The methods were classified into three group: colorimetry, gas chromatography and high performance liquid chromatography. The characteristics and availability of these methods in a laboratory for routine work were reviewed. The correction equation for the amounts of metabolites in spot urine is discussed.

Chromatography, Gas↗
PubMed1981

Generation of superoxide and hydrogen peroxide during interaction of nitrite with human hemoglobin.

Generation of superoxide and hydrogen peroxide during interaction of nitrite with human hemoglobin was detected by chemiluminescence of luminol. Luminol chemiluminescence was inhibited by the addition of superoxide dismutase (SOD) and catalase. Methemoglobin formation induced by nitrite was also inhibited by the addition of SOD and catalase. The mechanism of methemoglobin formation by nitrite was discussed in regard to the oxidation of hemoglobin by superoxide and hydrogen peroxide as generated by the interaction of nitrite with hemoglobin.

Catalase↗