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Biomedical subjects

M Notelovitz

Publications and source records attributed to M Notelovitz.

At least 109 records · Page 6Linked to original sources
PubMed1976

Insulin secretion in pregnant diabetic Indian women in Natal.

A study was undertaken to establish the plasma insulin response to an oral glucose load of 100 g in pregnant diabetic Indian women living in Natal. Eighty-three patients were investigated during the second and third trimesters of pregnancy and during the postpartum period. Although absolute mean plasma insulin values were lower than those found in non-diabetic controls, these patients exhibited compensatory hyperinsulinism typical of late pregnancy. This feature is not present in juvenile onset pregnant diabetic women. Metabolic control of the diabetic syndrome by insulin therapy is mandatory in the latter patients, whereas the former usually respond to the beta cell-stimulating sulphonylureas throughout pregnancy.

Adult↗
PubMed1976

Insulin secretion in healthy pregnant Natal Indians.

The pattern of insulin release in healthy pregnant Natal Indian women was determined. Progressive hyperinsulinaemia associated with advancing pregnancy was confirmed, together with evidence of a decreased sensitivity to insulin at a cellular level. The plasma insulin response returned to normal in the early puerperium.

Adult↗
PubMed1976

Placental lactogen in pregnant Natal Indian diabetic patients.

The plasma levels of human placental lactogen (HPL) in healthy and in diabetic pregnant Natal Indians were studied. The plasma HPL pattern in the control group was similar to that recorded in the literature and reconfirmed the increase in HPL during normal pregnancy. The plasma HPL of the pregnant diabetics was usually within 1 standard deviation of the mean normal value for that duration of pregnancy. HPL excess could not be incriminated as a cause for the disturbed metabolism in the women with diabetes.

Ethnicity↗
PubMed1976

Natural estrogen and anti-thrombin III activity in postmenopausal women.

Anti-thrombin III activity was measured in normal pre- and postmenopausal female controls: during late pregnancy, in young women taking oral contraceptives and in postmenopausal women treated with natural, conjugated estrogens. Both the pregnant patients and women on oral contraceptives had significantly lower anti-thrombin III levels when compared with the normal, untreated control group. Treatment with natural estrogens did not result in any alteration in anti-thrombin III activity. There was no significant difference in the anti-thrombin III values in the pre- and postmenopausal control subjects.

Adult↗
PubMed1976

Plasma insulin response following oral and intravenous glucose in pregnant diabetic women.

The acute release of insulin in most pregnant diabetic patients is sluggish. A study was undertaken to determine whether this abnormality was due to a relative insensitivity of the beta cell to glucose or to an attenuation of the enteroinsular axis. The plasma insulin response to intravenous and oral glucose was studied in third trimester pregnant insulin-independent diabetic and normal control patients. The results suggest that the sensitivity of beta cell reaction to glucose in the diabetic group was reduced and that this may be related in part to a defective enteroinsular response. Quantitative endocrine hypofunction, as evidenced by lowered plasma insulin levels, was also noted among the pregnant diabetic patients. The results are discussed in relation to the pathogenesis of disturbed carbohydrate metabolism in insulin-independent pregnant diabetic patients.

Administration, Oral↗
PubMed1976

Growth hormone secretion in insulin-independent pregnant diabetics.

A study was initiated to determine whether hypersecretion of growth hormone (HGH) was involved in the inhibition of normal glucose metabolism in pregnant insulin-independent diabetic (IID). A total of 25 patients was studied, of whom 13 had normal glucose tolerance and 12 were recently diagnosed IIDs. Hgh secretion was stimulated by insulin-induced hypoglycemia. The mean basal HGH levels and the plasma HGH pattern following the insulin stimulus were similar in the study group and the normal controls. Although it is unlikely that HGH participates to any significant degree in the diabetogenicity of normal and diabetic pregnancy, final proof depends on the assessment of the biologically active inhibitory polypeptide fraction of HGH and the growth-promoting protein, somatomedin.

Diabetes Mellitus↗
PubMed1975

Effect of natural oestrogens on blood pressure and weight in postmenopausal women.

An investigation of the effect of conjugated oestorgens (USP) on the blood pressure and weight gain of postmenopausal women was undertaken. Fifty-one unselected women were treated for one year with cyclically administered conjugated oestrogen. Both the mean systolic and diastolic blood pressures of those in the group increased, but only the diastolic was significantly elevated. Individual evaluation revealed that this was largely owing to an idiosyncrasy among certain women. Age is probably a predisposing factor, for hypertension occurred more frequently among the older women. The significance of the change in blood pressure is commented upon, and the recommendation that postmenopausal women on oestrogen replacement therapy should have their blood pressure measured every 6 months is made. Weight gain is not affected by long-term treatment with conjugated oestrogens.

Adult↗
PubMed1975

The effect of natural oestrogens on coagulation.

A study was undertaken to assess the effect of natural oestrogen on the coagulation profile of menopausal women. Forty-five postmenopausal women were selected at random and treated with conjugated oestrogen (PREMARIN) FOR ONE YEAR. Blood samples were tested before treatment, at the end of 3 and 9 months' therapy, and 1 month after treatment had been suspended. Parameters studied included: fibrinogen; platelet count and aggregation; single-stage prothrombin time; kaolin partial thromboplastin time; factors v and x assays and euglobulin lysis time. The only statistically significant alteration noted was a depressant effect on the platelet count. The significance of this change is commented upon. For practical purposes, it may be concluded that treatment of a group of menopausal women with conjugated oestraogen for one year had no adverse effect on their coagulation mechanism.

Adult↗