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Biomedical subjects

M Notelovitz

Publications and source records attributed to M Notelovitz.

At least 91 records · Page 5Linked to original sources
PubMed1980

When and how to use estrogen therapy in women over 60.

The most significant indications for estrogen therapy in women over 60 are symptoms related to the vagina, bladder, and bones. But before starting therapy, make certain these symptoms are directly related to estrogen deprivation, and not to the aging process. In patients on long-term therapy, use the lowest dose of estrogen plus progestogen that will alleviate the symptoms in the shortest period of time. Patients should be carefully monitored to reduce the risk of endometrial carcinoma.

Aged↗
PubMed1979

Effect of diazepam on serum testosterone and the ventral prostate gland in male rats.

A study was initiated to investigate the effect of diazepam on serum testosterone and testosterone-sensitive tissues in male rats. Diazepam was administered in a dose of 50 mg/kg body weight daily for 10 days. When compared with an equally matched group of control male rats, this dose of diazepam was associated with a significant reduction in both the weight of the ventral prostrate of treated rats and the serum testosterone levels. These changes were not associated with alterations in serum LH and FSH and the hypothalamic luteinizing hormone-releasing hormone content. Since diazepam does not interfere with the radioimmunoassay of testosterone, it is suggested that the above observations were biologically induced via direct suppression of the interstitial cells of the testis.

Animals↗
PubMed1979

Painless abruptio placentae.

Three cases of abruption of a posteriorly inserted fundal placenta are described. This condition is characterized by vaginal bleeding associated with backache, a nontender uterus, and if unrecognized, high fetal mortality. Ultrasonography permits early recognition and definitive diagnosis. Fetal survival is ensured by closely supervised monitoring and early recourse to cesarean section.

Abruptio Placentae↗
PubMed1978

The single-unit delivery system--a safe alternative to home deliveries.

The need has arisen for the development of a health care/delivery system that can allow for a natural and personalized childbirth experience, within the safe confines of a modern obstetric unit. The single-unit delivery system (SUDS) is designed to achieve this objective by: strict prenatal screening of patients into low- and high-risk categories, utilization of a single room for the entire labor process, and close personalized supervision of women in "normal" labor by trained midwives/monitrixes. Physicians supervise the entire unit and are directly responsible for the management of all high-risk and complicated labors. The SUDS concept has been tried in clinical practice and has been proved to be an effective method of providing safe and satisfying obstetric care without compromising modern obstetric standards.

Delivery, Obstetric↗
PubMed1978

Distribution of cytoplasmic estrogen and progesterone receptors in human endometrium.

Unoccupied estrogen receptors and progesterone receptors were measured in the cytoplasm of five sections along the length of endometrium obtained from noncancerous, premenopausal hysterectomy specimens. The concentrations of the two receptors were measured with tritiated estradiol or R5020 (a synthetic progestin), the latter two having been purified by high-pressure liquid chromatography, and were found to be highest in the fundus and lowest in the cervix. Progesterone receptor levels, ranging from 50 to 3,500 fmoles of R5020 bound per milligram of protein, were generally much higher in each section of the endometrium than estrogen receptor levels, which ranged from 0 to 500 fmoles of estradiol bound per milligram of protein. Near ovulation it seemed that the distribution profiles of both receptors became very steep, with more than a tenfold difference in the receptor levels being found between the fundus and the cervix. Receptor levels measured in endometrial samples obtained by curettage or aspiration should be interpreted with caution.

Chromatography, High Pressure Liquid↗
PubMed1978

Partograms.

Explore the source record for details and available documents.

Female↗
PubMed1977

Cold pressor test in women: effect on vaginal blood flow.

Vaginal blood flow changes in women were evaluated qualitatively by heat-flow discs mounted on cooled vaginal probe. Statistically significant increases in vaginal blood flow, systolic blood pressure, and pulse rate were found in seven normal subjects during a 4 minute immersion of one hand in ice water.

Adult↗
PubMed1977

Plasma free fatty acids in pregnant insulin-independent Natal Indian diabetics.

A study was undertaken in Natal Indians to determine the insulin secretory response and the comparative degree of free fatty acidaemia in normal and insulin-independent diabetic pregnant women. The fasting plasma FFA and glucose levels were found to be substantially greater in the diabetic subjects. The pattern of plasma FFA and glucose response to exogenous insulin was similar in both groups. Endogenous insulin produced a similar FFA response, but a markedly obtunded blood sugar response occurred among the diabetics despite adequate plasma insulin levels. The significance of the differential effect of endogenous insulin on FFA and glucose metabolism in pregnant insulin-independent Natal Indian diabetics is discussed.

Adult↗
PubMed1977

Tolbutamide-induced insulin release in pregnant diabetics.

A study was undertaken to determine whether the abnormal insulin release pattern in insulin-independent pregnant diabetics (IID) was due to a lack of stored insulin and whether their clinical response to treatment with tolbutamide was correlated with enhanced plasma insulin values. Ten pregnant diabetics in the third trimester of pregnancy were subjected to both an oral glucose tolerance test and an intravenous tolbutamide tolerance test. The results indicated that an enhanced early release of insulin could be evoked by intravenous tolbutamide. The biochemical inertia of the beta cell noted in pregnant IID is therefore more likely to be associated with a relative insensitivity of the beta cell to glucose or to a defect in the enteroinsular axis. Although the individual hypoglycaemic effect of intravenous insulin was similar, the plasma insulin response varied greatly. The clinical improvement in tolbutamide-treated diabetics cannot be explained solely on the basis of enhanced insulin release.

Adult↗
PubMed1977

Heat production of fetal sheep brain in utero.

Thermojunctions were implanted in the brains of 10 near term fetal sheep in utero under halothane anesthesia. Brief total occlusion of fetal brachiocephalic artery was followed immediately by an increase in brain temperature (mean +/- SE) of 0.130 +/- 0.014 degrees C-min-1. Occlusion of main pulmonary artery and ascending aorta, simultaneously, led to a brain temperature increase of 0.144 +/- 0.018 degrees C-min-1. Specific heat of three fetal brains was determined to be 0.898 +/- 0.014 cal-g-1. degrees C-1 or 3.76 +/- 0.059 J-g-1. Rate of fetal brain heat production, computed as the product of the higher rate of temperature change and brain specific heat, was 0.129 +/- 0.014 cal-g-1-min-1 or 9.00 +/- 0.98 mW-g-1.

Animals↗
PubMed1977

Coagulation, oestrogen and the menopause.

The objective of oestrogen replacement therapy in the menopause is the prevention of pathology attributable to oestrogen lack. Care should be taken to ensure that such therapy is free from harmful side effects. To date, there have been no long-term longitudinal studies or clinical reports that have positively identified oestrogen usage in "normal" postmenopausal women, with inappropriate thrombosis directly attributable to an oestrogen-induced alteration in the coagulation mechanism. This is surprising since certain coagulation factors change and the peripheral blood flow decreases in the elderly, predisposing them to enhanced clot formation. There is also the well-documented (but controversial) association between oestrogens, oral contraceptives and thrombosis. Whether this paradox can be explained by differences in the type and/or potency of the oestrogens used in ORT, remains to be determined. At present it may be concluded that ORT per se does not place the postmenopausal women at greater risk from developing arterio-venous thrombosis.

Aging↗
PubMed1976

The effect of long-term oestrogen replacement therapy on glucose and lipid metabolism in postmenopausal women.

A prospective study was undertaken to determine the effect on carbohydrate and lipid metabolism of long-term oestrogen replacement therapy in an unselected group of 34 postmenopausal women. Treatment was with cyclically-administered conjugated oestrogen (1,25 mg daily) for 24-43 months. Each patient served as her own control. The mean 2-hour postglucose level for the group at the end of the study was greater than the original baseline values, but the difference was not statistically significant. The mean serum cholesterol pre-beta-lipoprotein and beta-lipoprotein levels for the group were significantly reduced. Triglycerides were unaffected. It is suggested that treatment with conjugated oestrogens can maintain a normal lipid profile, provided that the original levels are within normal limits and that therapy is instituted early and is maintained. Carbohydrate and lipid metabolism in the majority of postmenopausal women on long-term conjugated oestrogen therapy will not be adversely affected.

Blood Glucose↗