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Biomedical subjects

M Nitta

Publications and source records attributed to M Nitta.

At least 163 records · Page 9Linked to original sources
PubMed1983

The results of anterior cervical fusion in cervical spondylosis. Review of 125 cases.

A retrospective study of 125 patients with cervical spondylosis with, in the main, myelographic features, and treated by the anterior cervical route (Cloward's operation) is presented. Patients were selected for this type of surgery as opposed to the posterior approach, on clinical and radiological grounds which are described. Results of this treatment have generally been good and this is particularly so in very elderly patients with a single lesion at C 3/4. There is a group of patients in whom the disease process seems to progress despite surgery.

Adult↗
PubMed1983

[Cerebral blood flow dynamics of spontaneous occlusion of the circle of Willis (Part 1)--comparison between electrophysiological findings and neuroradiological findings].

Four cases (2 children and 2 adults) of spontaneous occlusion of the circle of Willis were studied using EEG, somatosensory evoked potential (SEP), cerebral angiography and CT scan. The following results were obtained. 1) Among the above described parameters, SEP was the most useful to detect the ischemic change in the thalamus when the obstruction of the posterior part of the circle of Willis extends, even before a low density lesion of the thalamus appears on CT. 2) In child cases, a decrease in the amplitude N3 of SEP was observed after hyperventilation. It was speculated that this finding of SEP might be correlated with the mild cortical ischemia due to vasoconstriction and "rebuild up" phenomenon in EEG after hyperventilation.

Adult↗
PubMed1983

[Echocardiographic recognition of ruptured chordae tendineae: patho-anatomical evaluation of the diagnostic criteria].

Various pathological changes of the mitral valve (MV) apparatus have been reported to be associated with ruptured chordae tendineae (RCT). We studied the clinical importance of echocardiographic examination to detect the etiology of RCT in 15 cases with patho-anatomical findings obtained. The commonly observed echocardiographic abnormalities were diastolic MV flutter (80%), systolic MV vibration (73%), flicky (or exaggerated) MV motion (73%), MV prolapse (47%), and abnormal systolic echoes in the left atrium (53%). Diastolic flicky motion of the MV was observed exclusively in the patients of bacterial endocarditis accompanied with MV vegetations. The main ruptured chordae of the MV were recognized as floating chordal echoes. MV prolapse was associated with myxomatous changes of the valve or multiple echoes chordae tendineae. These results show that M-mode and two-dimensional echocardiography may be predictive to evaluate the etiology of RCT.

Adult↗
PubMed1982

Acute myelofibrosis terminating in erythroleukemic state.

A patient with acute myelofibrosis associated with erythroleukemia is described. The terminal course of the patient was marked by the erythroblast population in the peripheral blood increasing to a level of 21.8 x 10(3)/mm3, 18% of which were PAS-positive. Possible transformation of acute myelofibrosis into the erythroleukemic state is discussed.

Acute Disease↗
PubMed1982

[Correlation of vasospasm with operative results in ruptured aneurysms].

The present study is a retrospective clinicoradiological correlative investigation of subarachnoid hemorrhage associated with ruptured aneurysms. There were 360 patients in whom the source of subarachnoid hemorrhage was shown by angiography to be a ruptured aneurysm, and 302 of them underwent surgery. Arterial vasospasm was demonstrated in 113 of 360 patients (31%). When the time relationship between the subarachnoid hemorrhage and vasospasm was considered, vasospasms were revealed in 35 patients (31%) to ten days after a hemorrhage. In these cases with preoperative vasospasm, 17 patients were operated within 14 days and 43 patients later than two weeks. On the examination, their clinical state was graded according to Hunt and Hess. The surgical results were also grade in five groups (excellent, good, fair, poor and died) according to the functional results at discharge from the hospital. Of 35 patients of grade I and II at operation, 23 patients (66%) were of excellent or good results. However, of 14 patients of grade IV and V at operation, only on patient took good result. Of 12 patient in whom severe vasospasm was demonstrated and surgery was delayed more than two weeks, 8 patients (66%) had good result. Postoperative vasospasm was recognized in 2 patients, who took poor result. Surgery was carried out in 32 patients on the first or second day after subarachnoid hemorrhage, and 7 patients (22%) of them took good result. The overall mortality was 59% (19 patients). In ten patients, surgery was carried out on the third or fourth day after subarachnoid hemorrhage. Five patients had good result (50%) and four (40%) died. Considering the relationship between the timing and result of surgery, the mortality was 35% in patients operated on in the first week, whereas there were only 38 deaths among the 252 patients operated on after that interval. Among the death patients who were in grade IV or V at admission, intracranial hematoma was seen in 73%. It was concluded that in patients classified as grade I or II, the operation should be performed as soon as possible to prevent another rupture. In grade IV and V patients with severe damage by large hematoma, the mortality and morbidity were high even after evacuation of the hematoma. Patients with marked and diffuse vasospasm should be given conservative treatment at first and then operated on when the patients condition becomes good.

Adult↗
PubMed1982

[Contrast echocardiographic evaluation of right ventricular filling profiles in patients with right ventricular volume or pressure overload].

UNLABELLED: Contrast echocardiographic examinations were performed to evaluate hemodynamic filling profiles in patients with right ventricular overload as well as in normal adults. The subjects were 15 cases of atrial septal defect (ASD) as a representative of right ventricular volume overload, 13 cases of mitral stenosis (MS) as a condition with right ventricular pressure overload and 15 cases of normal adults. M-mode contrast echocardiograms were recorded through the ultrasonic beam direction determined by two-dimensional echocardiograms as shown in Fig. 1. RESULTS: 1) In diastole, continuous rapid linear flow through the tricuspid valve orifice was observed in 11 patients with ASD, while biphasic rapid linear flow was noted in normal adults (control) and in patient with MS. 2) Maximum flow velocity (MFV) in early diastole and flow velocity in atrial contraction phase (AFV) were larger in cases with ASD than that of the control subjects. However, there was no difference in rapid filling time (RFT) between patients with ASD and MS. 3) The characteristic findings of tricuspid valve echoes in cases of ASD included increased valve opening velocity (TOV), decreased diastolic descent rate (TDDR), and high F point. These findings were correlated well with increased MFV and prolonged RFT. 4) MFV was decreased secondarily to the increment of pulmonary artery pressure. 5) Turbulent flow in the right-sided chamber was observed in patients with pulmonary hypertension. These results suggest that linear contrast echoes in the M-mode echocardiograms may be useful for the evaluation of flow velocity and flow profiles across the tricuspid valve orifice in patients with right ventricular volume or pressure overload.

Adult↗
PubMed1981

Mitogenicity and adjuvanticity of a marine bacterium, Vibrio anguillarum, in mice.

The effects of whole cells of three different O serotypes of Vibrio anguillarum on the murine immune response were studied. The addition of different doses (1-100 microgram/ml) of V. anguillarum cells, as well as Salmonella typhimurium lipopolysaccharide, markedly increased the incorporation of [3H]thymidine into in vitro cultured spleen cells of C57BL/6 mice. All three serotype strains of V. anguillarum were able to induce the mitogenic effect at 10 microgram /ml and 100 microgram/ml, but serotype I strains were more potent than the others. Since pretreatment of spleen cells with rabbit anti-mouse thymocyte antiserum did not affect the mitogenic activity of V. anguillarum, Vibrio cells may be a B-lymphocyte mitogen. When sheep or horse erythrocytes and Vibrio cells were injected intraperitoneally into ddY mice, Vibrio cells exhibited an enhancing effect on antibody response in vivo, regardless of the different serotypes. Vibrio cells, when injected intraperitoneally into mice before the antigen, markedly suppressed the antibody response. Several days after the injection of Vibrio cells, these mice showed an enhanced carbon clearance activity. Acid phosphatase activity in their peritoneal cells was also augmented, suggesting that Vibrio cells activated macrophages in the mice.

Acid Phosphatase↗
PubMed1979

Antitumor activity of marine bacteria, Vibrio anguillarum, in mice.

Antitumor activity of marine bacteria, Vibrio anguillarum P-B-1, against Ehrlich carcinoma cells in ddY mice was investigated. Ehrlich carcinoma cells were inoculated intraperitoneally (ip) into mice and V. anguillarum (1.0 mg/mouse) was administered ip twice before and 4 times after the tumor inoculation. Groups of mice administered V. anguillarum survived 80 approximately 90% and their mean survival was 54.0 approximately 56.0 days (range, 24.0 approximately 60 days) at day 60 after inoculation of 10(4) to 10(6) tumor cells against the mean survival of 16.4 approximately 22.3 days (range, 7 approximately 26) in the control group. When 2 x 10(6) tumor cells were inoculated subcutaneously (sc) mixed with 1.0 mg of V. anguillarum, the bacterial cells markedly suppressed the growth of tumor at the injection site; tumor did not grow in 30% of recipient mice and the inhibition rate of grown tumor in the rest of recipients was 69%. The consistently demonstrable antitumor activity of V. anguillarum was reduced by pretreatment of mice with immunosuppressants such as anti-thymocyte serum, hydrocortisone, or irradiation of X-ray. This fact indicates that the antitumor activity of V. anguillarum is mediated by immune response.

Animals↗