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Biomedical subjects

M Nishio

Publications and source records attributed to M Nishio.

At least 343 records · Page 19Linked to original sources
PubMed1983

[Late local recurrence of cervical cancer after initial treatment].

Late local recurrence of cervical cancer more than 10 years after successful initial treatment is very rare. We now present 17 patients with late local recurrence. Only one patient had undergone primary surgery alone; the other 16 patients had received various types of radiotherapy. All 17 patients received radiotherapy as the second treatment. Local control was achieved in 9 patients, 4 of these survived for more than 5 years after the second treatment. Longterm follow-up for more than 10 years is important for the early detection of late local recurrence.

Adult↗
PubMed1983

[Calcification of the tricuspid annulus in association with pulmonary stenosis: report of a case].

A 51-year-old woman was admitted to our hospital because of palpitation, dyspnea and anterior chest discomfort. She had had a heart murmur since childhood. On physical examination, a rough grade 6/6 ejection systolic murmur was maximally audible at the second left intercostal space with a systolic thrill. The chest X-ray film showed the cardiothoracic ratio of 54% and the electrocardiogram demonstrated right ventricular hypertrophy. Calcification of the tricuspid annulus was recognized by chest X-ray films (anteroposterior and lateral views), M-mode and cross-sectional echocardiograms and the computed tomogram (CT) of the chest. Cardiac catheterization revealed the presence of valvular pulmonary stenosis and atrial septal defect. These findings were confirmed by surgical operation. Since the first description of Paktovskii in 1960, nine cases of calcification of the tricuspid annulus were reported, but no case has been described in the Japanese literature. Contrary to the mitral annulus, the echocardiographic and computed tomographic features of the calcification of the tricuspid annulus has not been reported previously. In this paper, we reported a middle aged patient with circumferential calcification of the tricuspid annulus in association with severe pulmonary stenosis and atrial septal defect, and the features of the echocardiogram and CT images were illustrated.

Calcinosis↗
PubMed1983

[Pharmacokinetics of a new antitumor antibiotic, neothramycin, after intrapleural administration].

In 5 patients with malignant pleural effusion, neothramycin (NTM) was intrapleurally administered at a dose of 30 mg in 3 cases and 40 mg in 2 cases and the pharmacokinetics was studied by using compartment models. The results were as follows: 1) Pleural levels of NTM were described by a mono-exponential equation and the half-life ranged from 3.45 to 6.48 hr. 2) The time to reach the maximum plasma level was 1 to 2 hr after pleural administration. The maximum levels were 54 to 106.4 ng/ml with the 30 mg dosage and 74.7 to 79.2 ng/ml with the 40 mg dosage, followed by a slow decline, with T1/2 ranging from 6.54 to 17.80 hr. 3) The elimination half-life of NTM in the plasma after intrapleural administration was much longer than that after intravenous administration. This phenomenon can be explained by a "flip-flop model": in this case, the rate of transfer from the pleural space to the plasma was much slower than that of the elimination from the plasma. 4) The parameters, K1 and K2, which were obtained by the deconvolution method, seemed to reflect the transfer of NTM between the pleural space and the plasma. 5) In 3 out of the 4 evaluable cases, an extreme decrease in the pleural fluid volume and suppression of reswelling were observed, including a case found to be negative for tumor cells upon cytodiagnosis.

Adenocarcinoma↗
PubMed1982

Neutral glycosphingolipids and gangliosides of bovine thyroid.

By the application of a ganglioside-mapping technique, the lipid composition of bovine thyroid was analyzed systematically. The contents of cholesterol, lipid-bound phosphorus and lipid-bound sialic acid in bovine thyroid were 5.10, 9.76, and 0.28 mumol/g of dry tissue, respectively, and the molar ratio of cholesterol, lipid-bound sialic acid, and lipid-bound phosphorus was 52.4 : 2.9 : 100.0. The following phospholipids were contained in this order: phosphatidylcholine greater than phosphatidylethanolamine greater than sphingomyelin greater than phosphatidylserine and phosphatidylinositol greater than cardiolipin. When compared on a molar basis, the amount of total glycosphingolipids was only 3% of phospholipids. As the major neutral glycosphingolipids, ceramide glucoside, ceramide galactoside, ceramide lactoside, ceramide trihexoside and globoside were identified and the most abundant component was globoside (40% of total neutral glycosphingolipids). On the other hand, five molecular species of gangliosides were identified: GM3, GM1, fucosyl GM1, GD3, and GD1a. Three types of GD3 and GD1a with a different sialic acid composition were recognized on the ganglioside-map and isolated in pure forms. GM3 was the most abundant component, but the concentration of gangliosides with ganglio-N-tetraose in bovine thyroid was higher than that of gangliosides with lactose. Also fucosyl GM1 comprised 13% of total gangliosides. Thus, the high concentrations of gangliosides with ganglio-N-tetraose and fucosyl GM1 seemed to be characteristic of bovine thyroid glycosphingolipids. The glycosphingolipids contained in the following order: GM3 greater than GD1a greater than globoside greater than GM1 greater than ceramide trihexoside greater than fucosyl GM1 greater than ceramide lactoside greater than ceramide glycoside greater than GD3 greater than ceramide galactoside.

Animals↗