Biomedical subjects

M Nguyen

Publications and source records attributed to M Nguyen.

220 records · Page 13Linked to original sources

PubMedDate not supplied

Plasma acid and alkaline phosphatase in patients with breast cancer.

Acid and alkaline phosphatase were determined in 107 breast cancer patients to study their potential value in case of bone metastases. The patients were divided into 4 groups: A, patients without metastases (n = 34); B, metastatic patients without bone lesions (n = 37); C, patients with metastases in and outside of bones (n = 24), D, patients with bone-only metastases (n = 12). Tartrate resistant acid phosphatase (TR-ACP), and bone alkaline phosphatase (bone-ALP) were significantly higher in patients with metastases than in patients without. However, no difference in TR-ACP was observed between subgroups of metastatic patients.

Acid Phosphatase↗

PubMedDate not supplied

[Study of the morphology of the intrinsic muscles of the pes cavus using x-ray computed tomography].

From the tomodensitometric examination of 9 cases of hollow foot, the authors present their methodology, reminding the difficulties encountered, and they analyze the results. After a first tomodensitometric study including 16 cases of normal feet, confirming the existence of a suro-achilleo-plantar system by studying correlations between plantar intrinsic muscles and muscles of the posterior compartment of the leg, they establish: the advantage of this method of evaluation of section areas and evaluation of the maximum traction force of the intrinsic muscles of the foot (reproducibility), the disorganization of this anatomo-functional unit in hollow foot syndromes.

Adult↗

PubMedDate not supplied

[Monocytic arthritis. Study of their clinical significance apropos of 43 cases].

The clinical significance of synovial monocytosis (greater than 50 p. cent) of inflammatory fluids (greater than 1,000 elements per mm3) was studied retrospectively in 43 patients. An accurate diagnosis was made 35 times: rheumatoid polyarthritis (13 cases), lupus disease (1 case), Gougerot-Sjögren syndrome (1 case), isolated infantile monoarthritis (1 case), sarcoidosis (1 case), seronegative spondylo-arthropathy (3 cases), microcrystalline arthritis (5 cases) arthritis revealing a blood disease (2 cases), idiopathic "lymphocytic" arthritis (3 cases), eosinophilic pseudo-allergenic arthritis (2 cases), aseptic osteonecrosis of the medial condyle (1 case), femoro-patellar arthrosis (1 case). Among the 8 other patient for whom no diagnosis was made, 6 had a spontaneously resolving acute affection, evoking the possibility of a viral etiology.

Adult↗

PubMedDate not supplied

Endothelium-specific expression of an E-selectin promoter recombinant adenoviral vector.

BACKGROUND: E-selectin expression is very low in normal adult blood vessels, but is significantly elevated in newly formed tumor capillaries. We hypothesized that a viral vector which has transcriptional specificity for the tumor vasculature may be a tool for angiogenesis-targeted gene therapy. We therefore designed an adenoviral vector which would only be expressed in cells that transcribe the E-selectin gene. MATERIALS AND METHODS: The E-selectin promoter was inserted into an adenoviral vector driven by the luciferase reporter gene. The resulting AdV-Esel-Luc vector was then used to transduce endothelial cells as well as other cell types, and luciferase activity measured with a luminometric assay. RESULTS: Exposure of transduced endothelial cells to TNF-alpha (tumor necrosis factor-alpha), a known inducer of the E-selectin promoter, generated a 30-fold increase in luciferase expression compared to untreated cells (p = 0.01). Endothelial cells cultured in tumor conditioned media as an in vitro recreation of the tumor environment resulted in even higher induction of luciferase (p = 0.0001). Furthermore, many non-endothelial cell lines expressed minimal levels of luciferase when transduced with the AdV-Esel-Luc vector under identical conditions. CONCLUSIONS: We conclude that the E-selectin promoter can be used in order to confer transcriptional specificity to an adenoviral vector. This transcriptional specificity may in the future enable us to deliver the specific expression of therapeutic genes to the tumor vasculature.

Adenoviridae↗