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Biomedical subjects

M Ndiaye

Publications and source records attributed to M Ndiaye.

125 records · Page 7Linked to original sources
PubMed1990

[Surgery of severe ischemias and infections of the foot in the diabetic. (Role of arterial revascularization)].

From overall data on 54 diabetic patients, who, over a period of 7 years, underwent operations to save their feet from ischaemia (whether linked or not to infection), the authors study 31 cases of revascularization through arterial bridging in the diabetic's lower limbs. The lesions were identified by doppler examination followed by arteriography. Various types of bridging were undertaken: 24 femoro-popliteal bridges, including 16 super-articular and 8 sub-articular ones; and 7 femoro-distal bridges on the leg artery trunks. For the post operational period, only one amputation, resulting from precocious thrombosis in the graft, had been noted. All the patients had been followed up, and the authors remarked that, after an average lapse of 43 months, actuarial survival without amputation of the lower limb amounted to 94.97% after 7 years, and the level of actuarial permeability of the bridges amounted to 72.61% after the same period. The authors stress that revascularization indications should be the same for atheromatous diabetics as for non diabetics.

Aged↗
PubMedDate not supplied

Podophyllotoxin-induced modifications of the nuclear envelope.

In spermatids of Culex tigripes (Culicidae) the manchette is composed of numerous expansion-bearing microtubules which surround the nucleus. Under the action of podophyllotoxin, in zones where manchette microtubules are absent, the nuclear envelope bulges and forms abnormal extranuclear vesicles. We hypothesize that this newly recognized capacity of podophyllotoxin is due to its action on microtubule-membrane relationships.

Animals↗
PubMedDate not supplied

First evidence of natural vertical transmission of yellow fever virus in Aedes aegypti, its epidemic vector.

Entomological investigations were conducted in 1995 in Senegal, following a yellow fever (YF) outbreak. A total of 1125 mosquitoes collected in the field, including males, females and 12-48 h old newly emerged adults reared from wild-caught larvae, were tested for YF virus. Among the 22 species captured, Aedes aegypti was the most common. 'Wild' vectors of YF were also captured, including A. furcifer, A. metallicus and A. luteocephalus. In all, 28 YF virus isolations were made: 19 from A. aegypti females, including 2 from newly emerged specimens; 5 were obtained from A. aegypti males, including one from a pool of newly emerged specimens, 2 from A. furcifer females, and one each from a female A. metallicus and a female A. luteocephalus. The true infection rates (TIRs) were much higher in adult A. aegypti than in specimens reared from larvae--8.2% and 31.4% for female and male A. aegypti captured on human volunteers, respectively (P < 0.0001). The TIRs for A. aegypti reared from larvae were 1.4% and 0.5% for females and males, respectively (P > 0.05). This outbreak was an intermediate YF epidemic, involving 4 vector species. Our data provide the first evidence of vertical transmission of YF virus in nature by A. aegypti, its main vector to humans, and strongly suggest that vertical transmission played a major role in the spread of the epidemic.

Aedes↗
PubMedDate not supplied

[Treatment of breastplate deformities: assessment using CT scanning and functional tests].

A study to evaluate both the pre- en postoperative functional and morphologic status of major anterior chest wall deformities. Four of the eight patients suffered from a progressive reduction in physical capabilities. Preoperative pulmonary function tests demonstrated restriction in pulmonary function. In the postoperative period there was progressive return to normal physical strength without objective improvement in pulmonary function. Pre- and postoperative thoracometric study by CT scan allowed us to evaluate the morphologic changes. Two patients with pectus excavatum (funnel chest) demonstrated not only a right-left asymmetry but also A-P compression of the heart without displacement to the left. We consider this to be one of the causes of functional impairment and an absolute indication for corrective surgery.

Adolescent↗
PubMedDate not supplied

[Infantile diarrhea in Senegal: epidemiologic survey in a suburb of Dakar].

Before the launching of a national program against diarrhoea in Senegal it was interesting to survey the exact impact of this disease on the under 5 children and the way the mothers and the community are dealing with it. We investigated a very crowded suburb of Dakar where we found that diarrhoea was the first cause of death among under five children. This investigation showed us that Oral Rehydration Therapy (ORT) is widely known by the approximately 1000 mothers interviewed, thanks to the gambian and senegalese broadcasts . However, only 1% of the mothers consider it as a useful and efficient treatment of diarrhoea. Expansive and inefficient medical treatments as well as traditional therapy are systematically preferred to ORT. We analyzed the reasons of that failure and we proposed a new strategy to generalize the use of ORT.

Administration, Oral↗
PubMedDate not supplied

[Radioimmunologic dosage of total IgE serum in various helminthiases and protozoan infections (author's transl)].

The both purposes of our investigation were to determine initially the level of total serum IgE in various parasitic infections and the variations of this level after the initiation of specific treatment. In the study, III sera from black race patients with a clinical and biological diagnosis of helmintic or protozoal infections and without allergic diseases were tested by the commercially available "Radioimmunosorbent test" (Pharmacia Laboratories). In helmintic infections: the IgE concentration was higher than normal level: --in 100% of patients infested with ankylostoma, trichocephalus (mean concentration m: 2,961 UI/ml) or schistosoma (m: 1,578 UI/ml); --in 70% of patients infested with ascaris (m: 1,110 UI/ml). In protozoal infections: the abnormal IGE level was found only in 44% and 14% of cases respectively of malaria (m = 704 UI/ml) and of leishmaniasis (441 UI/ml). The time course of total serum IgE determined after the treatment initiation showed that: a) in patients with intracellular helminthiasis and protozoal infections serum IgE concentrations were gradually increased in a statistically highly significant way; b) in cases with intestinal helminthiasis, high levels disappeared ane returned rapidly to normal values.

Adolescent↗
PubMedDate not supplied

Growth of tracheal sutures with absorbable sutures in primates.

Postoperative wound healing is studied after tracheal suturing in 5 primates operated on in two stages. First by double level hemisection comparing continuous and interrupted sutures with polydioxanone. In a second stage: comparison of continuous sutures after tracheal segmental resection. The tracheas were harvested sequentially to study the evolution of the sutured zone by measuring its diameter and by histopathologic examination. The reduction of the tracheal diameter observed was not statistically significant after hemisection using continuous (p = 0.7) or interrupted sutures (p = 0.6). But after tracheal resection the stenosis was significant with continuous sutures (p < 0.05). Histologic study revealed that polydioxanone is well tolerated and is absorbed within 26 weeks. The authors recommend the use of continuous sutures to repair simple wounds and of interrupted sutures after tracheal resection anastomosis.

Animals↗
PubMedDate not supplied

[The fluorosis problem in Senegal: data evaluation and presentation of a new method for defluoridating the water supply].

Fluoride intoxication is a serious public health problem in Senegal. The concentration of fluoride ions in underground water in Senegal is higher than the acceptable standard (0.7 mg/l at 25 degrees C) varying between 5 and 15 mg/l according to the season. The hydrological pattern of fluoride ions in Senegalese water is presented. The high levels of fluoride ions are due to the presence of phosphate ores. The health problems associated with the ingestion of toxic doses (about 4 mg/l) are discussed. Epidemiological investigation shows that the intoxication in Senegal is serious. In addition to fluoride in drinking water, high levels are also found in food, particularly tea and vegetables. Nanofiltration is a low cost membrane-based process which can be used to eliminate fluoride from drinking waters. Also known as low pressure reverse osmosis, this process is selective for small molecules and ions. It can thus sterilize and partially demineralize water. Furthermore, it can require only small amounts of energy, such that it can be run from photoelectric cells.

Filtration↗