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Biomedical subjects

M Nagase

Publications and source records attributed to M Nagase.

At least 235 records · Page 13Linked to original sources
PubMed1978

Recurrent common duct stones, with special reference to primary common duct stones.

A series of 1,358 cholelithic patients operated on at 32 affiliated hospitals during the last year and 492 patients operated on at authors' hospital during the last 21 years were reviewed with special reference to the cases of recurrent common duct stones. Of the former series 15 patients and of the latter series 12 patients respectively were reoperated on for recurrent, but not for residual, common duct stones, and all of them had in the markedly dilated common duct bilirubin stones showing characteristics of stasis stone-primary in common duct. Two representative cases are presented briefly. Congenital hypotonia of the common duct and inflammatory choledochitis are condemned and bilioenterostomy is recommended for preventing stone recurrences.

Bilirubin↗
PubMed1978

Present features of gallstones in Japan. A collective review of 2,144 cases.

A collective review of 2,144 patients operated on for cholelithiasis during the last twenty-two months has shown that younger Japanese adults have predominantly cholesterol stones in their gallbladders and that elderly persons still frequently have bilirubin stones not only in their gallbladders but also in their common bile ducts. Recent westernization of dietary habits in Japan is considered to be the most probable factor causing the increased incidence of cholesterol stones. The decreased incidence of bilirubin stones is considered to be caused by the decreased incidence of biliary infection and increased intake of proteins in food.

Adult↗
PubMed1978

Mesangial IgA glomerulonephritis. Clinicopathological study of 85 cases.

A clinicopathological study was made on 85 cases of mesangial IgA glomerulonephritis and of 49 controls. Predominant incidence of male over female was noted in IgA glomerulonephritis. The disease developed insidiously in a considerable number, and occupied 68% of chance proteinuria and/or hematuria. Macrohematuria was often experienced, but in a statistical comparison with controls, no specific features were observed clinically except that hypertensive cases were rarely encountered in this disease, which may reflect the better prognosis. Serum IgA levels were not different significantly in two groups. Histological changes were those of various natures and intensities, and no specific type of lesions were observed. The negative staining of C1q and C3PA in glomeruli of IgA glomerulonephritis offered no possibility to elucidate either of the complement pathways as active.

Adolescent↗
PubMed1977

Pathogenesis and treatment of pancreatitis due to essential fatty acid deficiency.

Pathogenesis of pancreatitis was studied in experimental animals and essential fatty acid deficiency was condemned as an etiological factor, since it caused pathological changes in permeability of cell membrane of the pancreatic acinar cells. Favorable effects of intravenous fat emulsion was clearly demonstrated in treatment for acute and chronic pancreatitis.

Acute Disease↗
PubMed1977

Renal hemodynamics in uranyl acetate-induced acute renal failure of rabbits.

The role of renal hemodynamic alterations in the curtailment of renal function was studied in rabbits with uranyl acetate-induced acute renal failure. The day following the i.v. injection of uranyl acetate (2 mg/kg of body wt), renal blood flow (RBF) and clearance of creatinine (Ccr) decreased to approximately 60 and 20% of controls, respectively. Intracortical fractional flow distribution, estimated by radioactive microsphere method, did not change. The extraction ratio of para-aminohippurate (EPAH) decreased and the renal extraction of sodium (CNa/Ccr) increased, with minimal structural change in the kidney. Urine output increased to two to three times that of the control. After three days oliguria appeared despite complete recovery of RBF. The zonal flow redistributed toward the deep cortex. CCr and EPAH reached their minimums, concomitantly with tubular necrosis and intratubular casts. After seven days animals could be divided into the oliguric and diuretic groups. CCr and EPAH were higher in the diuretic group, while there was no significant difference in RBF and the flow distribution between groups. Regeneration of damagee tubular cells was found in the diuretic group but not in the oliguric group. The findings suggest the minor roles of RBF and the intracortical flow distribution, and a fundamental role of back leakage of filtrate across damaged tubular epithelium in the maintenance of reduced CCR and urine output during the oliguric stage in rabbits with uranyl acetate-induced renal failure.

Acute Kidney Injury↗
PubMed1977

Decreased plasma postheparin lipolytic activity in systemic lupus erythematosus.

Plasma postheparin lipolytic activity (PHLA) was measured on 50 patients with systemic lupus erythematosus (SLE). Plasma PHLA was significantly decreased in SLE patients. This decrease was most striking in the acute phase of the disease. There was a close relationship between decreased PHLA and immunologic factors indicative of the acute phase of SLE. These immunologic factors included shaggy antinuclear antibody pattern, low serum complement titer, high DNA antibody titer, mixed cryoglobulin and lumpy glomerular pattern by immunofluorescent staining.

Adolescent↗