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Biomedical subjects

M N Volgarev

Publications and source records attributed to M N Volgarev.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Changes in the number of Ec cells in the small intestine and the serotonin level in the blood plasma of fasting rats].

A study was made of the amount of Ec-cells in the small intestine mucosa and blood plasma serotonin of rats in health and fasting. It was established that 24 hours after food deprivation the amount of Ec-cells rises approximately 2-fold as compared with control. The cells demonstrate the intensification of the argentaffin reaction. The content of serotonin in blood plasma increases 2-fold accordingly. On day 3 of fasting the amount of Ec-cells and intensity of the argentaffin reaction decrease to normal, whereas the content of blood plasma serotonin does not change essentially. This may be linked with a massive release of serotonin to blood and depletion of Ec-cells because of which the threshold of their histochemical demonstration is reduced. On day 7 of food deprivation the amount of Ec-cells and the intensity of the argentaffin reaction increase again but the serotonin content dramatically falls down. This phenomenon may be related to the derangement of serotonin release to blood or to the transformation from the synthesis of serotonin to the synthesis of some other hormone, most likely melatonin.

Animals↗
PubMed1984

[Effect of antigenic stimulation and fasting on liver lysosomes in rats].

Study of the interrelationship between immune responsiveness of the body and structural and functional status of the rat liver lysosomal apparatus under different alimentary conditions allowed one to establish that immune response during antigenic stimulation and complete fasting was considerably reduced. At the same time a dramatic rise in the total and non-sedimentable activities of some lysosomal hydrolases was recorded under the above conditions. The data obtained suggest that during acute malnutrition and antigenic stimulation, the rate of antibody synthesis is considerably decreased whereas activation of the lysosomal apparatus affected by both factors plays a compensatory role and is directed toward the most complete realization of the protective function of lysosomes.

Animals↗
PubMedDate not supplied

[Effects of polyunsaturated fatty acids in the ration on the structure of peripheral lymphoid organs, immunological parameters and nonspecific resistance of rats].

It has been established that the fatty component of the ration, with the rest ingredients being unchanged, alters the immunologic status of the body. When fatty portion of the ration was substituted for sunflower oil (omega 6) active macrophage-plasmocytic reaction in the lymphoid organs, elevation of the humoral immunity parameters and suppression of the T-cell system were recorded. The reaction to immunization was less pronounced when equal ratios of sunflower and ichtyenic oils were used. When the fatty component of the ration was completely substituted for ichtyenic oil, a decrease in T-lymphocyte number and focal necrotic changes in the lymphoid organs were observed. The fatty component of the rations used produced no significant effect on the bactericidal activity of the blood serum.

Animals↗
PubMedDate not supplied

[Enhanced resistance of mice (CBA strain) to infection caused by S. typhimurium depending on the nature of the fat in the diet].

Mice received rations containing a mixture of lard with sunflower oil, butter, cooking fat (hydrogenated), fish fat. Hydrogenated fat and fish fat induced a decrease in the portion of polyunsaturated fatty acid omega 6 in lipids of lymphocytes, Peyer's patches, mesenteric lymph nodes and the spleen. At the same time fish fat induced an increase of the portion of polyunsaturated fatty acid omega 3 in lipids studied. A relationship has been noted between the animal survival after intraperitoneal infection with S. Typhimurium and the fatty acid composition in lymphoid tissues. The highest survival rate has been recorded in the groups of animals that received cooking (hydrogenated) fat and fish fat.

Animals↗
PubMedDate not supplied

[Effect of dietary protein deficiency in female rats on the function of the immunocompetent system of their progeny].

The influence of alimentary protein deficiency, during early ontogenesis, on the morphofunctional characteristics of the immunocompetent system was studied in 115 experimental and 60 control female rats, 4 and 12 months after the commencement of the experiment. It was shown that protein deficiency in the period of prenatal ontogenesis induced significant changes in the humoral and cellular values, characterizing immunologic responsiveness and nonspecific resistance of the body, and leads to alteration of the morphological structure of the lymphoid organs. Such changes were also observed in the rats of the second generation, which received full-value food, thus evidencing grave and stable immunologic disorders as the result of protein deficiency during prenatal ontogenesis.

Animals↗
PubMedDate not supplied

[Effect of alimentary protein deficiency in the early postnatal period on the function of the immunocompetent system in rats].

The influence of protein deficiency in the early postnatal period on the functional and morphological characteristics of the immunocompetent system was studied in 76 test and 60 control rats, 4 and 12 months after the experiment commencement. It was shown that protein deficiency in the early postnatal period induced shifts in the cellular parameters of the immunologic responsiveness, mainly, producing no significant changes in the nonspecific factors of body defence. The impairing effect of protein deficiency was more manifest at the early steps of the body development.

Animals↗
PubMedDate not supplied

[Changes in the vessels of the kidneys in rats on a choline- and protein-deficient diet].

Prolonged (from 4 to 10 months) keeping of rats on a cholinoprotein- and protein-deficient diets produces an associated moderate damage to the wall on renal blood vessels and glomerulopathy. There take place dystrophic alterations in the elastic skeleton of the interlobular arteries in the form of elasticity loss and impairment of the tinctorial properties on the internal elastic membrane combined with vacuolization of the smooth muscle cells of the media.

Animals↗
PubMedDate not supplied

[Xanthurenuria at different stages of liver lesion induced by protein and choline deficiency].

The parallelism between xanthurenuria and liver affections caused by protein and choline deficiency was studied. At the stages marking the development of lipohepatosis and fibrosis there occurred an intensive passage of xanthurenic acid. The intensity of xanthurenuria at the stage marking the appearance of hyperplastic nodes continued to gain strength. With progressive advance of pathological changes, which by the 9--12th months of the experiment reached the stage of a fully developed nodular cirrhosis xanthurenuria gradually stopped.

Amino Acids↗
PubMedDate not supplied

[Enterochromaffin cells of the intestinal mucosa during long-term parenteral and intragastric feeding].

The authors studied the response of enterochromaffin cells (Ec-cells) of the duodenal mucosa of rats during parenteral and intragastric administration of food mixtures containing a fatty emulsion venolipid (Japan) and of food mixtures containing no fat. The food mixture was administered round the clock, uniformly throughout 15 days. The Ec-cells were detected by the argentaffinity method modified by Phontane . It was discovered that during parenteral and intragastric administration of the food mixture containing a fatty emulsion, the amount of the Ec-cells in the duodenal mucosa was 3 times greater as compared with control. There were cells with varying intensity of the argentaffinity response, which attests to an active release of hormones synthesized by the Ec-cells. During intragastric administration of the food mixture containing no fatty emulsion, the status of the Ec-cells was the most similar to that seen in control. This is suggestive of an important role of the diet fat for changes in the Ec-cells. The changes found should be taken into consideration in the assessment of the effects of parenteral and intragastric feeding on the body and intestine and in the choice of the most optimal methods of feeding.

Amino Acids↗