[The mechanism of action of polyunsaturated fatty acids on the immune system].
This article presents the literature materials about polyunsaturated fatty acids as nutritional immunomodulators.
Biomedical subjects
Publications and source records attributed to M N Volgarev.
This article presents the literature materials about polyunsaturated fatty acids as nutritional immunomodulators.
The retrospective analysis of 4 variants of norms of human physiological needs in food substances and energy accepted in 1951, 1968, 1982 and 1991 is given. Dynamics of the scientifically proved specification of value of needs is revealed and the necessity of permanent development of conceptual base of normalization is determined. Last one is based on two natural laws of a balanced diet: 1) compulsion of conformity energy expense and energy consumption; 2) the value of consumption of the basic food substances (fibers, fats, carbohydrates) should be in limits of physiologically necessary quantity proportion and be accompanied by satisfaction of human needs in different nutrients.
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The role of nutrition in the pathogenesis, therapy, and prevention of gastrointestinal diseases is discussed. Although nutrition is not a leading cause of most gastrointestinal diseases, the role of nutrition in their pathogenesis is very great. Nutritional monitoring of the Russian Federation's population has revealed a shortage of many essential nutrients to be consumed, which may result in worsening of various gastrointestinal diseases. The most promising way of solving this problem is to supplement their diets with biologically active additives (Nutricevtics) which may be a main source of essential nutrients, such as vitamins B, beta-carotene and omega 3-polyunsaturated fatty acids.
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Dietary intake of carbohydrates for Russian population increased from 50% to 54% of total energy intake at the expense of increasing of dietary intake of potatoes and bread products. This level of carbohydrate intake is in the normal value do not causing serious caution in relation to public health. Main resource of carbohydrates in russian diet is dietary intake of bread and bread products (about 53% of total intake), sugar and confections (25%) and potatoes (10%). Carbohydrates of fruits and vegetables make up about 5%, those of milk and diary food aso 5% of total dietary carbohydrates. Daily average intake of crude dietary fibers compose no more than 10 g per capita. Simple carbohydrates (sum of mono- and disugars) provide for about 20% of total energy intake and pure sugar gives about 12% of total energy intake of Russia's population.
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Morphologic examinations of liver, spleen, mesenteric lymph nodes and groups of lymphatic follicles of small intestine (Peyer's patchs) of rats in condition of starvation were shown. Starvation of animals for 48 hours and most for 96 hours was caused statistic reliable decrease of body mass, concerning mass of thymus and liver. Centrolobular fatty infiltration and decrease of RNA and glycogen contents in hepatocytes of liver were shown. Decrease of content of small lymphocytes of T-dependent zones and alteration of cell's representation in B-dependent zones were discovered.
Effect of antiatherosclerotic diet of 112 patients with cardioishemic disease IIa, IIb, and IV types was observed. Positive dynamics of clinical picture of disease, values of lipid metabolism and T-cell cents immunity were shown, particularly for patients with hyperlipidemy, which developed as result of effect of medium cents and genetic cents factors. Including to antiatherosclerosis diet polyunsaturated fatty acids of family (w-3) intensified hypolipidemic effect.
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The influence of dietary essential fatty acids on the immune functions and nonspecific resistance of male Wistar rats weighing 135.0 +/- 3.2 g was investigated after 3 months feeding. Rats were fed isocaloric purified diets containing 24% of fat (combinations of lard, sunflower oil and fish oil, eiconol, this providing the ratios of omega 6/omega 3 fatty acids equal to 1.1; 2.1; 6.1; and 49.0. An increase of immune responsiveness and nonspecific resistance in the groups fed diets with the minimal ratios of omega 6/omega 3 fatty acids as compared to that in rats fed a diet with ratio 49.0 was noted. Fatty acid analysis of peripheral lymphoid organs tissue lipids showed an increase in percentage of eicosenic omega 3 fatty acids in rats fed diets with increased content of polyunsaturated fatty acids omega 3.
Purified diets for rats contained 24% fat, with presented with the mixture of sunflower and fish oils whose combination yielded ratios of omega 6 to omega 3 fatty acids equal to 99 0, 49 0, 5 2, 1.9 and 0.12. The alterations in fatty acid composition of blood plasma and the liver were noticed, which manifested in increased omega 3 fatty acid levels in proportion to their dietary content. The elevation of PUFA proportion in the diet increased TBA-reactive substances in the liver. Using radioimmunoassay the levels of PGF2 alpha, TxA2 and PGI2 were determined. The decrease of arachidonic acid as part of tissue lipids caused an inhibition of PGF2 alpha formation in the liver, TxA2 and PGI2 in blood plasma, that showed a possibility of influence the ratio omega 6/omega 3 PUFA in a diet on eicosanoid synthesis by substrate regulation. These results suggest that for characteristics of dietary fat the ratio omega 6/omega 3 PUFA as a criterion reflecting the biological action of two families of essential fatty acids should not be used.
Actual nutrition patterns of pregnant women, breast-feeding mothers, and young children were analysed together with the breast milk composition in different regions of this country. The influence of maternal nutrition on the breast milk composition and infant health status is demonstrated. Special attention is devoted to the development and use of new food products for feeding healthy and sick children.
Studies of the actual nutrition and wide spectrum of biochemical, haematological, and anthropometric indices in the representatives of the native population of Kamchatka and Chukotka showed that along with the significant changes in nutritional patterns due to the added products, local sources of feeding (fish, sea mammals, deer meat) greatly contribute to fulfilling the physiological requirements and exert a specific effect on metabolic processes. This is mostly associated with the features of lipid metabolism as a result of marine fat intake. Recommendations on the rational nutrition organization in these regions are discussed.
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