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Biomedical subjects

M Muller

Publications and source records attributed to M Muller.

At least 235 records · Page 13Linked to original sources
PubMed1991

Production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by human neutrophils is inhibited by Pseudomonas aeruginosa phenazine derivatives.

Pyocyanin, a phenazine pigment produced by Pseudomonas aeruginosa, and its metabolite 1-hydroxyphenazine inhibited leukotriene B4 and 5-hydroxyeicosatetraenoic acid production by up to 70% in human neutrophils stimulated with the calcium ionophore A23187 (5 microM). This potential anti-inflammatory effect was dose dependent and occurred at low concentrations (10 to 50 microM) that did not inhibit neutrophil viability.

Calcimycin↗
PubMed1991

Multiple domains of the glucocorticoid receptor involved in synergism with the CACCC box factor(s).

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy we tested different human glucocorticoid receptor mutants for synergistic function with another transcription factor in comparison with intrinsic trans-activation obtained with a single receptor binding site (glucocorticoid response element). Multiple domains were found to be involved in synergistic activity of the glucocorticoid receptor with the CACCC box factor. Deletions within the N-terminal receptor half affected simultaneously intrinsic trans-activation and synergism. However, deletion of the hormone-binding domain mainly impaired synergism rather than intrinsic trans-activation, clearly showing that this domain synergizes by a mechanism independent of intrinsic activation. A chimeric protein where the DNA-binding domain of the glucocorticoid receptor was replaced by that of the yeast GAL4 protein also showed functional synergism. These data suggest that some of the receptor domains outside the DNA-binding domain synergize by their intrinsic trans-activating property, but the hormone-binding domain contributes to synergism by a different mechanism.

Animals↗
PubMed1991

Embryology and secretory activity of labial salivary glands.

This study was carried out on the heads of 20 foetuses aged between 11 and 26 weeks. Four stages were distinguished in the development of labial salivary glands, each stage corresponding to gestational age. Stage I is characterized by a localized, rounded thickening of the stomodial epiblast into the mesenchyma of the mucosal side of the lower lip. This occurs at the 9th-10th week of gestation. Stage II is reached when the epiblastic thickening assumes the form of a single cord. It is oval when sectioned transversally and is the result of the proliferation of epiblastic cells into the underlying mesenchyma during the 11th-12th week. Stage III corresponds to a branching process which takes place at the 13th week. The single cord branches to form the future secretory lobes, which rapidly assume a grape-like appearance. The number of rudimentary glands increases during the first three stages of development, i.e. as long as the first formed glands have not developed ducts. Stage IV corresponds to the process of duct formation at the 18th week. Simultaneous differentiation of acinal and duct cells is observed and this procedes the onset of secretory activity.

Basement Membrane↗
PubMed1990

The Dandy-Walker syndrome.

Ten cases of the Dandy-Walker syndrome are presented. The clinical manifestations are analyzed. Almost 80 percent of these children had associated anomalies. The characteristic findings are based on the magnetic resonance image scan. Satisfactory treatment of our patients had mostly consisted in shunting the lateral ventricular system to the peritoneum. The incidence of the complications was high.

Abnormalities, Multiple↗
PubMed1990

[Research methodology for the formulation of nursing standards].

The purpose of this article is to describe the research methodology to be utilised when formulating nursing standards. Standards guide the practice and should be formulated within the context of the culture of a country, its philosophical and ethical values, and its social, economic and political development. Two approaches of standard formulation were identified, namely a national generic approach and a decentralised, specific approach. A structured two-phase model is recommended, consisting of a developmental and a quantification phase. In the case of national standards, statistical determination of the content validity of the standards is recommended by means of a content validity index determination of each standard.

Humans↗
PubMed1990

[Ethics and dentistry].

Is Odontology asserved to ethical? Three thought's axis are considered: 1. Ethical and research. 2. Negligence during cares. 3. Refusal to give cares (AIDS).

Acquired Immunodeficiency Syndrome↗
PubMed1990

[Dental eruption cysts in small children].

Cysts commonly develop at the time of eruption of deciduous teeth. Excision is easy to perform. Eruption cysts should be differentiated from neonatal epulis and hemangioma.

Diagnosis, Differential↗
PubMed1990

[Recommended or forbidden: focus on chewing gum].

The use of chewing-gum may be beneficial to oral hygiene and become part of an anti-cavity prevention protocol. The conditions of use must be well defined: the sweetener should not be used by the bacterial plaque and fluoride, an anti-cavity agent, must enter into its composition.

Chewing Gum↗
PubMed1989

Cooperative interaction of chicken lysozyme enhancer sub-domains partially overlapping with a steroid receptor binding site.

Expression of the lysozyme gene is a marker for the differentiation of macrophages, lysozyme transcription being gradually increased during maturation. We have analyzed the fine structure and function of two macrophage-specific enhancer elements of the chicken lysozyme gene (E-2.7 kb and E-0.2 kb). Both increase their activities upon LPS induction, both contain multiple binding sites for similar or identical nuclear factors and both can be divided into two functional modules. For the E-0.2 kb enhancer we found a synergistic activity of the modules to be dependent on their distance. Binding sites for nuclear proteins within enhancer E-0.2 kb overlap substantially with the previously identified progesterone/glucocorticoid receptor binding site, which is required for steroid induction of lysozyme transcription in the oviduct.

Animals↗
PubMed1989

Elevated apolipoprotein(a) levels in cancer patients.

Elevated plasma lipoprotein(a) has been associated with an increased risk of cardiovascular disease. We report a significant elevation of total plasma apolipoprotein(a) levels in cancer patients compared with hospitalized control patients and normal healthy blood donors. Of the cancer patients studied, 48% had levels in excess of 350 mg/l compared to 20% in normal blood donors and 29% of hospitalized control patients. The elevation was more prevalent but less extreme than that reported in patients with cardiovascular disease. Density gradient centrifugation studies of plasma from cancer patients revealed the presence of apolipoprotein(a) at a density of 1.085 g/ml in the region where mRNA-containing proteolipids, neoproteolipids and malignancy-associated lipoproteins had previously been isolated.

Apolipoproteins A↗
PubMed1989

[Oro-facial diagnosis of battered children (Silverman syndrome). Management].

In France, 6 children on 1,000 are abused or neglected. The orofacial lesions are most often evocatives, but the diagnosis is sometimes delicate. The laws and the deontologic code are not precise concerning the attitude of the dentist facing a Silverman syndrome. In U.S.A., 8% of all dentists responding saw suspected cases of child abuse. We have not such statistics in France. The structures of protection and taking in care seems to be unknown of our collegues.

Child↗
PubMed1989

[Creating an optimal learning environment].

The charge sister, or first-line nursing manager, is the king pin in clinical teaching of the student. The teaching function of the ward sister is discussed with emphasis on the principles of guidance, leadership and motivation, which is essential for establishing an optimal learning environment.

Education, Nursing↗
PubMed1989

Evaluation of a sanitation programme using eggs of Ascaris lumbricoides in household yard soils as indicators.

Soil samples were analysed for the presence of Ascaris lumbricoides eggs as indicators of environmental pollution in household yards in Maputo, Mozambique, with the objective of evaluating the impact of a programme for the promotion of improved latrine construction. The locations for soil sample collection were defined by a random grid on which household activities were mapped. In addition, parasitological examinations were carried out amongst household residents. No significant difference was found between the type of latrine in use and the presence of Ascaris eggs in the soil or human Ascaris infection. Households with at least one infected person appeared more likely to have Ascaris eggs in the yard. It was notable that egg counts around the latrines were only slightly greater than in other areas of the yard and less than those immediately in front of the dwelling. This is taken to indicate that faecal pollution of the household environment is due more to promiscuous defecation than to poor construction or maintenance of the latrines. The findings highlight the need to complement sanitation 'hardware' with the necessary health education 'software'. Ascaris eggs are useful indicators but robust standardized methods are needed for their extraction from household soils.

Adolescent↗
PubMed1988

Many transcription factors interact synergistically with steroid receptors.

Progesterone (PRE) or glucocorticoid receptor (GRE) DNA binding sites are often found clustered with binding sites for other transcription factors. Individual protein binding sites were tested without the influence of adjacent factors by analyzing isolated combinations of several transcription factor binding sites with PREs or GREs. All show strong synergistic effects on steroid induction. The degree of synergism is inversely related to the strength of the GRE. Thus, a steroid responsive unit can be composed of several modules that, if positioned correctly, act synergistically.

Base Sequence↗