Search PubMed⌕ Search

Biomedical subjects

M Mostert

Publications and source records attributed to M Mostert.

70 records · Page 4Linked to original sources
PubMed1983

Atypical and polymorphic angioblastic tumors of the central nervous system.

Five central nervous system (CNS) polymorphic angioblastic tumors have been studied. Four were located in the posterior fossa and one involved the temporal lobe. In reviewing the literature, the authors point out the rarity of the supratentorial locations and of malignant hemangioblastomas. The clinical and anatomopathological peculiarities are discussed, as is the uncertain classification of two cases. The discrepancy between histology and outcome is focused upon in the other three cases. Finally, the diagnostic, prognostic, and nosographic difficulties posed by CNS angioblastic neoplasms are discussed.

Adult↗
PubMedDate not supplied

Derangements of pyruvate dehydrogenase in circulating lymphocytes of NIDDM patients and their healthy offspring.

Pyruvate dehydrogenase (PDH) is poorly active in circulating lymphocytes of NIDDM patients; in vitro, it is unresponsive to insulin at 5 microU/ml and activated at 50 microU/ml, instead of activated and inhibited as in healthy controls. This study examines whether healthy offspring of NIDDM patients with a family history for this disease have these alterations. Twenty seven healthy offspring (23+/-10 yr, median 18 yr) and their parents (13 diabetic with a family history for NIDDM and 11 healthy without this history) were enrolled. Twenty healthy individuals without the history and matched for age and gender with the offspring served as controls. Minimum levels for enzyme activity before and after cell stimulation with insulin at 5 microU/ml were computed for a 95% CI with no more than 5% of the controls excluded. Increased or unvaried enzyme activity in response to insulin at 50 microU/ml was defined as abnormal. All NIDDM parents and 11/27 offspring had below normal enzyme activity and defective and reversed enzyme response to insulin at 5 and 50 microU/ml; three offspring had altered enzyme response to insulin at both concentrations, four to insulin at 5 microU/ml, three to insulin at 50 microU/ml and six, together with the healthy parents, had no alterations. We conclude that in healthy individuals a family history for NIDDM is frequently signaled, irrespective of age, by molecular derangements, with an apparent genetic background, in their circulating lymphocytes.

Adolescent↗
PubMedDate not supplied

Effects of iopamidol on neonatal thyroid function.

The effects of Iopamidol on neonatal thyroid function have been investigated. Since the basic molecule is non-ionic, thyroid function is not damaged, even when large quantities of contrast media are employed.

Female↗
PubMedDate not supplied

The distribution of age at menarche in a random series of Turin girls followed longitudinally.

A longitudinal study on 508 girls chosen at random from the elementary schools of Turin showed that age at menarche had a Gaussian distribution. The mean age was 12.58 +/- 0.05 years. Peaks of incidence of menarche were observed in January and July-September. The correlation coefficient of mothers' (recollected) age at menarche with daughters' was 0.32.

Adolescent↗
PubMedDate not supplied

Patients with Hashimoto's disease treated with L-thyroxine and followed for three years.

This study investigated the effectiveness of L-thyroxine management in 32 patients (mean age 11 years and 2 months; M:F = 1:5) with Hashimoto's disease followed annually for 3 years. One (8%) of the 12 patients, euthyroid at the onset, never required treatment; of the four (33%) who began treatment immediately, two were able to stop at the 1st or 2nd follow-up, whereas two had to continue. The other seven (59%) who did not begin treatment immediately had to start at the 1st, 2nd or 3rd follow-up. The findings in this small series suggest that hormone management may prove effective to a certain extent in euthyroid Hashimoto patients, primarily as a means of prevention.

Adolescent↗
PubMedDate not supplied

Factors at onset predictive of lasting remission in pediatric patients with Graves' disease followed for at least three years.

Seventeen pediatric patients (mean age at diagnosis 10 yr and 9 mo +/- 2 yr and 9 mo) with Graves' disease treated with 0.3-0.7 mg/kg/day methimazole and followed for at least three years, during which drug suspension was attempted on attainment of good clinical and metabolic compensation, were retrospectively studied to look for factors predictive of lasting remission present at onset. Lasting remission was defined as a clinical and laboratory picture of euthyroidism lasting at least one year in the absence of treatment at the end of the follow-up. A distinction was drawn between patients who reached remission after one or two courses (groups 1 and 2) and those who never attained a lasting remission (group 3). TRAb (TBIAb) levels at onset were the only factor significantly correlated with the response to treatment. Age at diagnosis, goiter size and fT3 and fT4 concentrations were not significantly correlated with the clinical picture. The series was too small to allow any assessment of the real importance of these factors, though a generally better response was displayed by children over 11 years old, without appreciable or with very small goiter and moderately increased thyroid hormone levels at onset (fT3 < 25 pg/ml in 10/10 in groups 1 and 2 and 2/7 in group 3 patients; fT4 < 40 pg/ml in 7/10 in groups 1 and 2 and 3/7 in group 3 patients). It was also found that better results were obtained when the initial drug course was protracted for at least two years.

Adolescent↗
PubMedDate not supplied

[A multidisciplinary diagnostic and therapeutic approach to atopic eczema in the nursing infant: the 1-year follow-up].

This study presents the outcome of a multidisciplinary approach to the infants with atopic dermatitis. Forty six patients, 40 males and 6 females, afflicted with atopic dermatitis, aged 3 months-2 years, were examined. A careful history was taken for each case to identify possible allergic disease and particular attention was placed on the relation between food assumption and appearance of lesions. The association of diet, dermatological therapy, elimination of environmental stimulus where possible, treatment of lesions and pruritus and good psychological support enable the Authors to obtain 57% of complete remission of atopic dermatitis. In 43% improvement was observed.

Combined Modality Therapy↗