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Biomedical subjects

M Moschos

Publications and source records attributed to M Moschos.

52 records · Page 3Linked to original sources
PubMedDate not supplied

Clinical experience with cyanoacrylate tissue adhesive.

In this paper 385 cases treated with cyanoacrylate tissue adhesive during the years 1980-1995 are studied. The indications, outcomes and complications of cyanoacrylate adhesive are investigated and the results are analysed. It is encouraging that except for three cases of ocular hypotony and two cases of microbial infection no other complications occurred. Even in desperate cases with corneal perforation greater than 3 mm and ocular infection, enucleation was avoided. The early use of a bandage contact lens, inserted just after the glue application and the coverage with topical antibiotics switched every 15 days until the removal of the glue, may explain the small incidence of infection. Our experience from the use of cyanoacrylate tissue adhesive in cases with corneal perforation greater than 3 mm is very encouraging. In these cases a running 10.0 nylon suture was used to create a reticulum over the space of the corneal perforation upon which the glue was applied. The use of cyanoacrylate tissue adhesive offers to the clinician a safe technique for healing corneal wounds that avoids tectonic penetrating keratoplasty with its associated complications.

Adolescent↗
PubMedDate not supplied

The effect of low-dose interferon treatment on visual evoked potentials.

Patients suffering from chronic viral hepatitis, treated with interferon alpha-2b in a dose of 3 million units trice weekly subcutaneously, were studied. The influence of interferon on the optic nerve was evaluated by measuring the P100 implicit time of the visual evoked potentials. The results before the treatment were compared with those after 6 and 12 months of therapy, as well as with those of normal subjects. There were statistically significant differences between the groups. Furthermore, in 10 of 56 eyes (17.8%) after 6 months of treatment, and 8 of 22 eyes (36.3%) after 12 months of treatment, the P100 was abnormally delayed. The long term neurovisual effects of low-dose interferon are currently under investigation.

Adolescent↗
PubMedDate not supplied

The prognostic value of visual evoked response latency in the treatment of amblyopia caused by strabismus.

Visual evoked response alterations and especially P100 latency were studied in 60 patents with amblyopia caused by strabismus. Patients were divided in two groups according to the mode of fixation of the strabismic eye. Group A included patients with eccentric fixation, and group B, patients with central fixation of the strabismic eye. In all cases visual evoked responses were recorded before and after a 6-month period during which the patients had full-time occlusion of the sound eye. In cases with eccentric fixation of the strabismic eye, P100 latency was more abnormal than in cases with central fixation. In cases where latencies are clearly abnormal before treatment, the prognosis is poor and the results after occlusion of the sound eye are unstable. In contrast, in the cases with normal or nearly normal visual evoked response latencies, the prognosis is better, and these eyes show satisfactory improvement of visual acuity.

Amblyopia↗
PubMedDate not supplied

Cone properties of the light-adapted murine ERG.

PURPOSE: Because the mouse lacks a typical Purkinje shift, we have examined its light-adapted ERG to determine whether there was other evidence in addition to tolerance to background light, that could be used to identify cone function in the ERG. METHODS: Full field corneal ERGs to white flashes, double flashes and flash trains were examined in the presence of a strong full field light adaptation and compared with the human cone ERG. RESULTS: The following cone-like properties could be identified. (1) The light-adapted murine ERG increases in amplitude gradually during the first 10 minutes of light-adaptation; (2) It is capable of responding to a 50 Hz stimulus, although its overall frequency response is slower than that of the human cone ERG; (3) A corneal positive d-wave occurs to the termination of a flash train; (4) The response increases linearly with light intensity. CONCLUSION: The light-adapted murine ERG has several properties of cones but it has a slower response than the human cone ERG.

Adaptation, Ocular↗
PubMedDate not supplied

Recurrent vitreous hemorrhages due to combined pigment epithelial and retinal hamartoma: natural course and indocyanine green angiographic findings.

We report the clinical and angiographic features as well as the natural course of an optic disk and juxtapapillary combined pigment epithelial and retinal hamartoma in a 23-year-old white girl. The patient presented 3 episodes of recurrent vitreous hemorrhages in the first 4 years of follow-up, which were spontaneously and totally absorbed. During the last 6 years, she was absolutely free of any ocular symptom. The tumor did not show any growth during the 10 years of follow-up. The digital indocyanine green angiography, which was normal in the early frames, revealed a mild, patchy hyperfluorescence corresponding to the tumor location in the late phase.

Adult↗
PubMedDate not supplied

Photodynamic therapy with verteporfin of choroidal neovascularization in angioid streaks: conventional versus early retreatment.

PURPOSE: To evaluate the effectiveness of conventional photodynamic therapy with verteporfin (PDT) in a series of patients with macular choroidal neovascularization (CNV) due to angioid streaks and to compare it to the effectiveness of early PDT retreatment. METHODS: This is a retrospective study of 24 eyes (22 consecutive patients) with subfoveal or juxtafoveal CNV secondary to angioid streaks treated with PDT from September 2000 through February 2003 and that completed at least the first year of follow-up. Until August 2001, retreatments were performed according to the conventional protocol for PDT every 3 months (Group 1, consisting of 11 eyes of 9 patients). After August 2001 (13 more eyes of 13 new patients), retreatments were performed earlier (every 8 weeks) when indicated (Group 2). The follow-up time ranged from 30 to 42 months and from 12 to 30 months in Groups 1 and 2. RESULTS: At the end of the follow-up, final best-corrected visual acuity decreased in 21 (87.5%), stabilized in 2 (8.3%), and improved in 1 (4.2%) of the total 24 eyes. In all, 19 of the 24 eyes (79.2%) had a final best-corrected visual acuity equal to or less than 20/400. There were not any statistically significant differences in final visual acuity between the two groups. CONCLUSIONS: In this large series of patients with macular CNV secondary to angioid streaks, the functional and the anatomic results of PDT were not satisfactory, even when retreatments were performed earlier than the conventional time of 3 months.

Adult↗
PubMedDate not supplied

Spontaneous recovery of progressive anterior ischemic optic neuropathy.

During the last 5 years much discussion has occurred about the progressive anterior ischemic optic neuropathy of nonarteretic type and the usefulness of surgical optic nerve sheath decompression for its treatment. The description of cases with spontaneous recovery of the disease made some authors reserved or against this method and the whole subject has been debated with skeptisism. In this article three cases of progressive nonarteretic anterior ischemic optic neuropathy with spontaneous recovery are described. In all these cases visual acuity, as well as visual evoked responses, was spontaneously ameliorated and the optic disc swelling was resolved. Only the visual fields defects remained almost the same. The question arising from this study is whether or not surgical optic nerve sheath decompression in these cases was the only appropriate method of treatment, as some authors propose.

Aged↗
PubMedDate not supplied

Multifocal ERG in retinal detachment surgery.

PURPOSE: The main purpose of this study is to evaluate the visual function of eyes operated on for rhegmatogenous retinal detachment. METHODS: Fifteen patients were studied suffering from peripheral retinal detachment treated with the Lincoff-Custodis method. Visual field was tested with the Humphrey Field Analyzer and the analyzer program 30-2, which scanned a 0-30 degrees field. The multifocal ERG was recorded with the VERIS III (Visual Evoked Imaging System, Tomey, Nagoya, Japan). RESULTS: There was great loss of retinal response densities in the area of retinal detachment (1.3 +/- 0.7 nV/deg2). However, a decrease in retinal response densities was also recorded in the reattached retina (6.90 +/- 0.7 nV/deg2). CONCLUSIONS: MFERG is an objective tool for monitoring the functional abnormalities affecting the vision of eyes operated for retinal detachment.

Adult↗