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Biomedical subjects

M Morimoto

Publications and source records attributed to M Morimoto.

At least 397 records · Page 22Linked to original sources
PubMed1980

Venous angiomas of the brain.

Two cases of venous angioma of the brain are presented. Both were discovered by computed tomography and diagnosed by angiography. The lesion was located in the right frontal lobe in 1 case and in the left cerebellar hemisphere in the other. Neither was operated on because of the deep location or extent of the lesion. The 2 cases showed significant angiographic and hemodynamic differences. The literature on venous angiomas of the brain is reviewed. We proposed classifying venous angiomas into two subgroups based on angiographic findings: those with early-appearing vessels and those without. No significant differences in clinical manifestations were noted between these two subgroups in spite of the hemodynamic differences.

Adult↗
PubMed1980

Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system.

The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration. The compounds tested were 7-N-phenyl-, 7-N-(p-aminophenyl)-, 7-N-(p-hydroxyphenyl)- and 7-N-(p-chlorophenyl)-mitomycin C. The maximum increases in life span (ILSmax) obtained were 124, 169, > 386 and 112%, respectively, that with mitomycin C being 104%. 7-N-(p-Hydroxyphenyl)-mitomycin C showed a higher ILS% than its ortho and meta isomers. Thus, 7-N-(p-hydroxyphenyl)-mitomycin C was the most effective of these compounds.

Animals↗
PubMed1979

Herpes zoster of the maxillary branch of the trigeminus nerve. Virological and serological studies.

A 70-year-old male had erythematous and vesiculous lesions in the area of the right maxillary branch of the trigeminus nerve and was clinically diagnosed as having herpes zoster; virological and serological investigations of this case were carried out. Consequently, an electron microscopic observation revealed a great number of virus particles of herpes type in the vesiculous lesion and in baby hamster kidney BHK21/WI-21 cells, cultured after inoculating the fluid from the vesicle formed on the patient's upper lip or from serum harvested during the viremia. When BHK21/WI-21 cells infected with this virus were tested for antigenicity by an indirect immunofluorescent staining technique, they showed a positive staining to antivaricella-zoster virus. When serum of this patient was assayed fof the antibody level against varicella-zoster virus by the complement fixation test at various time intervals during the therapeutic period, this antibody titer on recovery period showed a threefold increase in comparison to that at onset. From these findings, this infectious disease was precisely diagnosed as herpes zoster.

Aged↗
PubMed1979

Attenuated mumps virus therapy of carcinoma of the maxillary sinus.

This paper presents treatment of carcinoma of the maxillary sinus with an attenuated mumps virus. The mumps virus was inoculated into two cases of very advanced carcinoma of the maxillary sinus by local and general injection. Shortly after injection, relief from severe cancer pain and growth inhibition or necrosis of tumor were observed in both cases. In this communication, we discuss a possible mechanism of antitumor effect of mumps virus by utilizing immunologic tests and interferon assay.

Carcinoma, Squamous Cell↗
PubMed1977

The role of the liver in the changes of acid-base balance and plasma lipids during surface-induced deep hypothermia.

The role of the liver in the changes of acid-base balance and plasma lipids in surface-induced deep hypothermia for open-heart surgery was investigated clinically and experimentally. The metabolic acidosis generally observed in open-heart surgery under surface-induced deep hypothermia is derived from lactacidemia. Although the accelerated anaerobic glycolysis is partly responsible, the depressed acidic metabolite-disposing ability of the liver also plays an important role. The evidence which is presented to show the decrease of plasma lipids other than NEFA under hypothermia is probably due to the hepatic accumulation of lipids and the decreased lipids release from the liver.

Acid-Base Equilibrium↗