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Biomedical subjects

M Morgan

Publications and source records attributed to M Morgan.

At least 361 records · Page 20Linked to original sources
PubMed1981

Autoimmune blood dyscrasias in five patients with hypogammaglobulinemia: response of neutropenia to vincristine.

Five patients with autoimmune blood dyscrasias and primary hypogammaglobulinemia are described. The autoimmune neutropenia in two patients rapidly responded to vincristine but was resistant to steroids. The three patients with autoimmune hemolytic anemia responded to steroids. Vincristine is therefore the drug of choice in patients with autoimmune neutropenia and hypogammaglobulinemia and is preferable to a trial of steroids in severely ill patients. Two of the patients had increased numbers of circulating T suppressor cells for in vitro immunoglobulin production. It is therefore unlikely that the autoimmunity in these patients is based on a lack of such suppressor cells.

Adolescent↗
PubMed1981

Extradural opioids for postoperative analgesia. A double-blind comparison of pethidine, fentanyl and morphine.

Pethidine 50 mg, fentanyl 100 microgram and morphine 2 mg administered to the extradural space, were compared in the treatment of pain following surgery. All three drugs produced a rapid decrease in pain scores as assessed using a visual linear analogue, morphine being the least effective. Fentanyl had a relatively short duration of action (2 h), whereas morphine appeared to be the longest acting. It is suggested that the best relief of pain would be obtained by incremental doses given extradurally. All drugs produced an increase in sedation, but there was no respiratory depression as assessed by PaCO2 measurement.

Adult↗
PubMed1981

Inadvertent intra-arterial injection of flucloxacillin.

Flucloxacillin 500 mg in 5 ml water was accidentally injected into a radial artery. This resulted in gangrene of parts of the thumb, index and middle fingers, necessitating amputation. Gangrenous areas requiring skin grafting also occurred in the forearm.

Adult↗
PubMed1980

The chemical neutralization of inhaled sulfuric acid aerosol.

We hypothesize that gaseous ammonia (NH3) released into respiratory airways can neutralize inhaled acidic particles and alter or mitigate their toxicity. To test this hypothesis, we have examined the relationship between respiratory NH3 and the chemical neutralization of inhaled sulfuric acid (H2SO4) aerosol in the surgically isolated upper airways of anesthetized dogs. With air entering via the mouth, the NH3 concentration measured at the larynx, ranged between 30 and 225 parts per billion (ppb). The extent of neutralization at this point ranged from 8%-70% (n = 16) for the 0.5-micrometer particles and 7%-22% (n = 16) for the 1.0-micrometer particles. With air entering via the nose, the laryngeal NH3 concentrations ranged between 50 and 220 ppb. Neutralization values were between 15%-65% (n = 8) for 0.5-micrometer particles, and between 16%-18% (n = 3) for 1.0-micrometers particles. For both routes of entry, the extent of neutralization was correlated with the laryngeal NH3 concentration. We conclude that the chemistry of acidic particles is significantly altered by respiratory NH3 during inhalation. The extent of neutralization is related to both the NH3 concentration in the airway and the size of the particle entering the airway. The extent of neutralization per ppb of laryngeal NH3 is related to the route of entry, being greater for the mouth than the nose.

Aerosols↗
PubMed1980

Initial experience with Minaxolone. A water-soluble steroid intravenous anaesthetic agent.

Minaxolone has been used to induce anaesthesia, and in incremental doses to supplement nitrous oxide, in 100 patients undergoing minor surgical procedures. Half the patients received a small dose of fentanyl before induction. Minaxolone proved to be a satisfactory induction agent. The commonest complications were an increase in muscle tone and involuntary muscle movements, which in some patients occurred in the recovery period: their incidence was reduced by fentanyl. There was a notably low incidence of nausea and vomiting.

Adult↗
PubMed1980

Respiratory effects of Minaxolone.

The respiratory effects of induction of anaesthesia with Minaxolone 0.4 mg/kg were studied following premedication with either atropine alone, lorazepam and atropine or papaveretum and hyoscine. There was no significant difference in the incidence of apnoea in the three groups. Those who received non-narcotic premedication showed a significant increase in respiratory rate, but the minute volumes in these patients did not differ significantly from control values in the third minute after injection of minaxolone. In those who received papaveretum and hyoscine, there was no change in respiratory rate and a highly significant reduction in minute volume.

Anesthesia, Intravenous↗
PubMed1980

ICI 35868 (Diprivan): a new intravenous induction agent. A comparison with methohexitone.

ICI 35868 (Diprivan) has been used as an induction agent in patients undergoing minor gynaecological surgery and as the sole anaesthetic agent during bronchoscopy, and its effects were compared with those of methohexitone. The new agent proved to be satisfactory, although induction of anaesthesia was significantly longer than following methohexitone. complications were similar with both drugs. ICI 35868 deserves full investigation as an intravenous anaesthetic agent.

Adult↗
PubMed1980

A regional programme to collect plasma for preparation of human immunoglobulin anti-rabies.

We identified over 100 recipients of rabies vaccine (human diploid cell vaccine) and recruited them as plasma donors. Some were plasmapheresed at static centres, others by mobile teams. The operation of these teams is described in detail. No plasma was sent to the Fractionation Centre until the date of vaccination had been checked. Assay results showed that the majority of plasma collected between four and 20 weeks after the second dose of vaccine contained 6 or more IU/ml.

Antibodies, Viral↗
PubMed1980

Comparison of thiopentone and methohexitone as induction agents for Caesarean section.

Anaesthesia was induced with equipotent doses of either thiopentone or methohexitone in 127 women undergoing Caesarean section. They divided into three groups: those having normal placental function, those with an undefinable degree of placental insufficiency, and emergencies. There was no clinical or biochemical difference in the neonates following induction of anaesthesia with either thiopentone or methohexitone. The clinical condition of neonates born of mothers with normal placental function was superior to the other two groups.

Anesthesia, Intravenous↗
PubMed1979

The right ot strike.

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Collective Bargaining↗