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Biomedical subjects

M Montes

Publications and source records attributed to M Montes.

At least 145 records · Page 8Linked to original sources
PubMed1975

Membranoproliferative glomerulonephritis with polyarteritis: a case report.

A case of membranoproliferative glomerulonephritis with polyarteritis is described. The patient was a 68 year old male who had the disease for about four months. A kidney biopsy specimen taken just before the patient died was studied by light, immunofluorescence, and electron microscopy. Splitting of the basement membrane, IgG, IgA, BlC, Clq, fibrinogen, and electron dense deposits were found in the glomeruli. It is considered that perhaps some cases of membranoproliferative glomerulonephritis are produced by circulating immune complexes.

Age Factors↗
PubMed1975

Interstitial immune complex nephritis in patients with systemic lupus erythematosus.

Interstitial immune complex nephritis in patients with systemic lupus erythematosus (SLE). Renal tissues from 45 patients with SLE nephritis, 34 patients with idiopathic membranous nephropathy (IMN) and 77 patients with minimal glomerular disease (MGD) were studied by light, immunofluorescence and electron microscopy. Interstitial nephritis characterized by focal or diffuse infiltration of inflammatory cells, tubular damage and interstitial fibrosis was observed in 66% of SLE patients. Fluorescein-conjugated antibodies to immunoglobulins or complement or both were bound to peritubular capillaries, interstitium and tubular basement membranes (TBM) in 53% of patients with a granular pattern corresponding to opaque deposits seen by light or electron microscopy or both. Antibodies reactive with thymidine or cytosine or both were bound to interstitial structures in 19% of patients tested and showed the same granular distribution. Interstitial cellular infiltration was rare and deposits of immunoglobulins and complement were rare or absent in IMN and MGD, whereas deposits of DNA products were never observed. The findings are consistent with the interpretation that in patients with SLE nephritis immune deposits, presumably containing DNA-anti-DNA complexes, localize in peritublular capillaries, TBM and interstitum, thereby producing an inflammatory reaction which contributes to development and evolution of renal diseases.

Antibodies↗
PubMed1975

Hemorrhagic infarction: A reperfusion injury following prolonged myocardial ischemic anoxia.

Sixteen canine myocardial pedicle preparations were divided into four groups. Group I received 60 minutes of reversible ischemic anoxia, Group II 90 minutes, Group III 120 minutes, and Group IV 180 minutes. Transmural ischemic infarction was present in Group I. With longer periods of anoxia, capillary disruption occurred, first in the subendocardium (90 minutes) and then transmurally (180 minutes). Reperfusion after ischemic, anoxic time periods of 90 minutes or greater produced hemorrhagic necrosis, the extent of which was directly proportional to the duration of the preceding ischemic, anoxic period. One hundred and twenty patients with aortic valve replacement surgery then were analyzed retrospectively. Of the 25 deaths, seven were due to immediate postinfarction, five from subendocardial hemorrhagic necrosis. The common factor in the patients with hemorrhagic infarction was a markedly reduced coronary flow (45 to 55 ml. per minute) for more than 70 minutes during the interval of cardiopulmonary bypass. Although other factors may be involved, it is hypothesized that the main cause is a degree of localized ischemia of sufficient duration to induce capillary disruption and subsequent postbypass hemorrhagic necrosis when normal coronary artery perfusion is resumed.

Animals↗