Search PubMed⌕ Search

Biomedical subjects

M Miyata

Publications and source records attributed to M Miyata.

At least 505 records · Page 28Linked to original sources
PubMed1987

Studies of a brain polypeptide functioning as a putative endogenous ligand to benzodiazepine recognition sites in rats selectively bred for alcohol related behavior.

The brain content of Diazepam Binding Inhibitor (DBI), its cell location and that of its specific mRNA were studied immunohistochemically and by in situ hybridization. Various strains of rats were genetically selected for their alcohol tolerance and the above mentioned brain parameters were studied before and after chronic ethanol consumption. The DBI like immunoreactivity (DBI-LI) was found to be located in selected neuronal population and in non-neuronal cells. The DBI-mRNA was located in brain areas where DBI is abundant. It was immunochemically determined that the DBI content was increased in cerebellum and in hypothalamus of alcohol preferring rats after chronic ethanol consumption. DBI content was compared in the cerebellum of rats genetically selected for different alcohol sensitivity and it was significantly higher on the ethanol sensitive (ANT) rat strain.

Alcoholism↗
PubMed1987

[Clinical study of ofloxacin (OFLX) on urinary tract infections].

Fifty-three patients with urinary tract infections (UTI) were treated with Ofloxacin, a new oral synthetic antimicrobial agent, and its clinical efficacy was studied. Ofloxacin (600 mg/day) was administered to 35 patients with acute simple cystitis for more than three days, and to 17 patients with complicated UTI for more than five days except a case in which the treatment was interrupted for side effects. Acute simple cystitis: In ten cases meeting the criteria of UTI committee, overall effectiveness rate was 100%. All of the 26 strains isolated from 26 patients disappeared after the treatment. In all of acute simple cystitis cases, 94.3% were evaluated as excellent or as moderate by attending doctors. Complicated UTI: In 11 cases treated during five or seven days, 63.6% of patients showed improvement on pyuria. Seven out of nine strains isolated from seven patients disappeared. However, two strains of P. aeruginosa and P. cepacia persisted after the treatment. In all of the complicated UTI cases, 38.9% of patients were evaluated as excellent or as moderate by attending doctors. Some slight side effects were observed in four out of 53 cases. This study showed that Ofloxacin is effective against urinary tract infections.

Acute Disease↗
PubMed1987

[A resected case of recurrent carcinoma of the right colon ten years after the initial operation].

A 59 year-old female complained of right lower abdominal mass. She underwent radical operation 10 years ago for the right colonic cancer staged Dukes C. She had passed 10 years without any sign or symptom of recurrence. She noticed a egg-sized tumor in the right lower abdomen unexpectedly one month ago when she got a bruise on that region, and then the tumor grew rapidly. Preoperative examinations, including barium enema, abdominal computerized tomography and so on, suggested a extraluminal tumor with infiltration to the colon. Laparotomy revealed that the tumor originated from the right paracolic gutter. The tumor sized 18 X 11 X 8 cm was resected and histological diagnosis was adenocarcinoma with the similar structural pattern to the initial specimen. On the basis of both operations and histological findings, we concluded that free tumor cells might be implanted in the large raw surface of the right dorsolateral abdominal wall, which was created by surgical incision at the initial operation, and subsequently appeared as a local recurrence after 10 years interval.

Adenocarcinoma↗
PubMed1987

[Clinicopathologic study on the mode and degree of invasion of the trachea by thyroid carcinoma].

Among 23 patients with thyroid carcinoma infiltrating to the trachea, total 7 laryngectomy and 16 tracheal resection were carried out, associated with thyroidectomy and neck dissection. The infiltrating mode and degree to the trachea in these patients were classified into 2 types according to the anatomical characteristics: Types of cartilage and membranous portions. Moreover, the former was further subclassified into 3 divisions. The subtype I of cartilage portion: Infiltration to the adventitia of trachea. Histologically, there were 3 well differentiated carcinoma, 3 poorly differentiated carcinoma and one medullary carcinoma. The prognosis was favorable comparing to other types. All 7 patients are alive. The subtype II or III of cartilage portion: Infiltration to the cartilage or annular ligament of trachea. Poorly differentiated carcinoma were noted in 6 of 7 patients. Five are alive and 2 died. The membranous type: Infiltration to the membranous portion of trachea. Esophageal invasion was noted in 7 patients. Undifferentiated carcinomas and squamous cell carcinoma took over a half of the patients. Two are alive and 7 died. The prognosis was the worst.

Adenocarcinoma, Papillary↗
PubMed1987

[A case of carotid body tumor. A review of 84 cases in Japanese literature].

We encountered one case of carotid body tumor. The patient was a 63-year-old man. The tumor was 5 cm X 6 cm in size, and it was strongly adhered to the carotid artery. Therefore, the tumor was removed with combined resection of the adherent lesion of the carotid artery. During the operation, we used a temporary external bypass method to prevent brain damage. The resected part of the carotid artery was reconstructed with saphenous vein graft. Angiogram one year after operation showed good patency of the graft. In Japanese literature, this is the second report of carotid body tumor removed by temporary bypass and the first report of use of a external bypass tube.

Aged↗
PubMed1987

[Comparative studies on the DNA content of human gastric cancer cells and its metastatic foci].

Comparative cellular DNA content measurements have been done on two sites differing from each other in their anatomical location, in 16 cases of gastric cancer by means of microphotometry. In addition, comparisons on the DNA stemline of the original gastric lesions and their metastatic lesions (8 cases of liver metastases and 9 cases of lymph node metastases) also were done. The main stemlines in four cases (25%) out of 16 gastric cancers exhibited different main DNA stemlines from the other sites in the same lesion, although in the other 12 cases examined, two sites showed the same DNA stemlines to each other. In almost all cases, the DNA stemlines of the metastatic foci were consistent with those of the original lesions. The lymph node metastases simulated the original lesions in its DNA stemlines (89%) more than did the cases of livermetastases (63%). In an exceptional case, the original lesion exhibited two definite stemlines (2C & 3.5C), but only one (2C) was recognizable in the metastatic focus of the liver. This difference indicates the probable role of "clonal selection" in a blood-borne metastasis.

Aged↗
PubMed1986

Omental transposition and skin graft in patients for advanced or recurrent breast cancer.

Nine patients, including 4 with primary advanced breast cancer (stage IV) and 5 with local recurrent cancer, underwent chest wall reconstruction using an omental flap and mesh skin grafting. In 2 of these patients the defect of bony chest wall was reconstructed with an acryl-resin plate and omental flap. The postoperative course in all patients was uneventful, except for a slight necrosis on the transposed mesh skin. Flail chest or dyspnea did not occur in those with a bony chest wall reconstruction. The immediate postoperative performance status in 6 of 9 patients and also quality of life improved.

Adenocarcinoma↗
PubMed1986

Surgical clinicopathologic study of malignant fibrous histiocytoma.

Fifteen men and six women, ranging in age from 20 to 79 years, with malignant fibrous histiocytoma comprised this series. Amputation of the right lower extremity was performed in one patient, wide resection in 7 and marginal excision in 9, respectively. In the other 4 patients, a non-curative resection was carried out. Adjuvant chemotherapy was prescribed post-operatively for 12 patients. Histologic grade of the surgical specimens was Stage I in 3, II in 6, III in 8 and IV in 4. Among fourteen patients living from 10 months to 9 years and 9 months after the operation, the 7 subjected to a wide resection are all disease free. Seven patients died of a local recurrence or a distant metastases. The survival rate of the patients with Stages I, II is significantly higher than those with Stages III, IV. These results show that a wide resection is to be favored and that staging is useful to estimate the prognosis.

Adult↗
PubMed1986

Interconnections between the subthalamic nucleus and the cerebral cortex of the cat.

The corticosubthalamic and subthalamocortical projections were examined in the cat by anterograde and retrograde axonal transport of horseradish peroxidase (HRP). Injections of HRP into the gyrus proreus, gyrus sigmoideus anterior and the part lateral to the sulcus cruciatus gave rise to anterogradely labelled terminals in all parts of the ipsilateral subthalamic nucleus in a topographical manner. Injections of HRP into these cerebral cortices as well as the gyrus sigmoideus posterior, the posterior part of the gyrus coronalis and the middle part of the gyrus ectosylvius produced retrogradely labelled neurons in the medial half of the ipsilateral subthalamic nucleus in a topographical manner. These findings suggest that the subthalamic nucleus acts as a link not only in the pallido-subthalamo-pallidal loop but also in the corticosubthalamo-cortical pathways.

Animals↗
PubMed1986

The fiber type of the rabbits' striated external urethral sphincter: electrophoretic analysis of myosin.

The fiber type of the rabbits' external urethral sphincter was investigated with O'Farrell's 2-dimensional electrophoresis of constituent proteins of glycerinated muscle, peptide mapping of myosin heavy chains and non-denaturing pyrophosphate gel electrophoresis of myosin. It was determined as fast type by all three methods. The relative proportions of muscle fibers which were estimated from myosin light chain contents were 88 per cent fast type and 12 per cent slow type. On the basis of the results presented, it was shown to be fast twitch muscle, but not identical to the psoas muscle.

Animals↗