Search PubMed⌕ Search

Biomedical subjects

M Mignon

Publications and source records attributed to M Mignon.

At least 235 records · Page 13Linked to original sources
PubMed1980

[Cimetidine treatment of anastomotic ulcers (author's transl)].

Fifteen patients with anastomotic ulcer were treated with cimetidine for 30 days. Endoscopy showed healing or marked regression of the ulcer in 53% of the cases. Neither the type of operation previously performed nor the amount of gastric secretion prior to entering the trial gave any indication as to which patients would respond to treatment. Other authors using the same therapeutic regimen have obtained similar results, but some have reported that extending treatment up to 8 weeks seems to produce considerably better results. The present authors conclude that cimetidine may constitute a suitable alternative to a second surgical operation.

Adult↗
PubMed1980

Interest of a combined antisecretory treatment, cimetidine and pirenzepin, in the management of severe forms of Zollinger-Ellison syndrome.

Inhibition of gastric acid secretion by the combined use of cimetidine and pirenzepin has been studied in 5 cases of Zollinger-Ellison syndrome. In 4 acute cases i.v. cimetidine and i.m. pirenzepin were administered together as a treatment and were successful in 3 out of the 4 cases as judged by the disappearance of clinical symptoms and healing of the gastroduodenal and jejunal mucosal ulcerations. Secretory measurements indicated that addition of pirenzepin to cimetidine resulted in larger and more prolonged inhibition of acid secretion in these patients. The continuous record of intragastric pH in the 5th patient, over 24-hour periods, confirmed the above findings. Despite the use of large doses of pirenzepin, no significant side effects were noticed.

Adult↗
PubMed1980

[Effect of a liquid protein meal on acid secretion, gastric emptying and serum gastrin before and after fundic vagotomy for duodenal ulcer].

Using a technique adapted from the intragastric titration method of Fordtran and Walsh, food-stimulated acid secretion, gastrin release and gastric emptying have been investigated before and after proximal vagotomy in 11 duodenal ulcer patients. Vagal denervation of the proximal stomach resulted in (i) a 40 p. 100 decrease in acid secretion in response to a protein meal; this response was of the same magnitude as the reduction in pentagastrin-stimulated acid output, (ii) a marked increase in food-induced gastrin release, suggesting a relationship between antral gastrin release and fundal vagal innervation since antral pH remained constant and the amount of protein and the distension volume within the antrum were the same as before proximal vagotomy, (iii) a slowing down of the initial phase of gastric emptying of the liquid protein meal in 5 patients, a slight acceleration in 4 and no change in 2. The clinical relevance of these findings is discussed.

Adult↗
PubMed1979

Cimetidine treatment of acute and chronic Zollinger-Ellison syndrome.

Thirteen patients with Zollinger-Ellison syndrome (ZES) were treated with cimetidine. This population could be divided into chronic forms, mostly presenting as a common duodenal ulcer, and acute forms resulting in critical problems requiring intensive medical care. Among the 7 patients with chronic ZES, cimetidine treatment was unsuccessful in 2; satisfactory clinical control was obtained in 3 others, but gastrinoma excision was the final treatment; cimetidine treatment has been prolonged for more than 15 months in the last 2 patients. If, in this condition, acute pharmacologic secretory inhibition were constantly obtained, therapeutic efficiency criteria are not sensitive enough to establish certainty in the patient's long-term follow-up. Total gastrectomy is still a valuable alternative if excision of the gastrinoma is not possible. Of the 6 patients with acute ZES, 4 were treated by pirenzepin (0.5 mg/kg intramuscularly 3 times a day) adjunctive to cimetidine infusion (2.4 mg/day), which resulted in increased antisecretory activity. However, total gastrectomy was the final outcome in every patient, with 1 immediate postoperative death. In conclusion, cimetidine in ZES treatment, although capable of inducing ulcer healing, diarrhea disappearance, and dramatic secretory inhibition, is still challenged by surgery, which allows either complete cure of the gastrinoma or definitive suppression of the secretory virulence.

Acute Disease↗
PubMed1979

[Prolonged treatment of Zollinger-Ellison by cimetidine (author's transl)].

Treatment of Zollinger-Ellison syndrome with cimetidine is justified by prior pharmacological studies; close survey of the patients is necessary, using clinical (endoscopic control of ulcer; diarrhea) and biological (BOA measurements and assessment of cimetidine efficiency) criteria. On the basis of 7 patients suffering from of chronic forms of ZES treated with cimetidine for periods varying from 56 to 570 days, a therapeutic scheme is suggested, allowing individual choices in the following problems:-possibility of gastrinoma complete excision, -advantages and disadvantages of cimetidine vs. total gastrectomy in respect to side-effects and acid secretion suppression, -variations in drug efficacy according to time (prolonged secretory inhibition, escape phenomenon).

Cimetidine↗
PubMed1979

Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test.

The aim of this study was to look for a difference in fasting serum gastrin levels or in serum gastrin response to oral feeding between infants with hypertrophic pyloric stenosis and normal controls. Fasting serum gastrin levels were measured by radioimmunoassay in 10 patients with pyloric stenosis, before pyloromyotomy and 7 and 15 days after it, and in 11 controls. In addition, the serum gastrin responses to a casein hydrolysate meal were studied in both groups (in the patients, 7 days after operation). The fasting serum gastrin levels in the patients did not differ from those in the controls before operation, but they did so after it. The serum gastrin response to feeding in patients after pyloromyotomy was no greater than in controls.

Caseins↗