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Biomedical subjects

M Mignon

Publications and source records attributed to M Mignon.

At least 217 records · Page 12Linked to original sources
PubMed1984

[Efficacy of a new antisecretory agent (40 749 RP) on human gastric secretion induced by a meal (intragastric titration)].

An antisecretory drug of a new series, 40 749 RP, without anticholinergic or H2 receptor antagonist activities, was tested on meal-induced gastric acid secretion in 6 healthy volunteers. Gastric acid secretion and emptying of liquid were measured using intragastric titration. Oral dosages tested were 1, 2 and 4 mg/kg versus placebo. Inhibitions obtained were dose-related and expressed in percentage of the placebo values: 36 +/- 10 p. 100 for 1 mg/kg; 51 +/- 13 p. 100 for 2 mg/kg and 83 +/- 5 p. 100 for 4 mg/kg. Statistically significant correlation (p less than 0.001) was observed between maximal blood concentration of 40 749 RP and the percentage of secretory inhibition during the 90 min of the test. No change in gastrin response or in gastric emptying was observed whatever the dose.

Adult↗
PubMed1983

Evaluation of antisecretory drug therapy of Zollinger-Ellison syndrome (ZES) using 24-hour pH monitoring.

Clinical and endoscopic findings were compared with 24-hr pH profiles in 8 patients with Zollinger-Ellison syndrome (ZES), who were being treated, during consecutive periods, with doses of cimetidine or ranitidine. There was a positive correlation between the effect on gastric pH and the outcome of treatment, with ranitidine proving to be more effective. The reduction of gastric acidity was correlated with ranitidine plasma levels. In the medical management of ZES patients, the 24-hr pH profile appears to be a measurement which is of value in the choice of appropriate drug regimes and which promises to increase our understanding of treatment failure.

Adult↗
PubMed1983

Epithelial cell proliferation in the rectal stump of patients with ileorectal anastomosis for ulcerative colitis.

Epithelial cell proliferation in the rectal stump after ileorectal anastomosis for ulcerative colitis was studied in 19 patients. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautographic analysis of the number and position of labelled nuclei in the crypts. Rectal biopsies from nine unoperated patients with ulcerative colitis and from 10 controls, were processed simultaneously. Except for one, all patients were clinically in remission. The crypt length and number of labelled cells per crypt column were found to be similar in the rectal mucosa from the three groups of subjects. The mean labelling index, although low 8.9%, was higher (p less than 0.05) in operated patients compared with controls; but the dispersion of individual values was similar in both groups. There was an extension of the proliferative compartment towards the surface in 88% of unoperated patients and in 60% of operated patients. In addition, there was a shift of the major zone of proliferation from the lower to the middle third of the crypt in 17% of operated patients and from the lower to the upper third of the crypt in 14% of unoperated patients. No correlation was found between the labelling index and either the age of patient, the duration of disease or the period elapsed after ileorectal anastomosis. Interestingly, among operated patients with a colitis for over 10 years, 42% had a quite normal proliferative pattern with a corresponding mean postoperative period of 7.5 years.

Adolescent↗
PubMed1983

A zinc-deficient diet for ruminants: diagnosis and treatment of deficiency.

A zinc deficient diet which is not semi-synthetic was tried on 20 male Limousin X Romanoff three and a half month-old sheep weighing 36 kg on average. This diet was composed of strawy hay sprayed with caramel containing urea and minerals. Compared to hay alone this diet is more appetizing to lambs and more equilibrated as to energy level and soluble nitrogen utilization. The deficiency appeared within a week in zinc plasma and progressed clinically within 100 days. The plasmic free zinc and alkaline phosphatase were not better criteria for the deficiency diagnosis than total plasmic zinc. Supplementing the diet to 50 or even 100 mg Zn/kg DM was insufficient to suppress the deficiency. Zinc injection, by contrast, restored zincemia to normal in ten days. Zinc deficiency treatment by oral route should be reconsidered.

Alkaline Phosphatase↗
PubMed1982

[Hyperparathyroidism associated with Zollinger-Ellison syndrome. 4 cases (author's transl)].

In approximately 20% of the cases the Zollinger-Ellison syndrome (ZES) is associated with primary hyperparathyroidism (HPT). In view of this frequent association, serum calcium and phosphorus levels should be measured in all patients with ZES. Conversely, all patients with HPT I accompanied or preceded by peptic ulcer and/or diarrhoea should have their gastric acid secretion and serum gastrin level measured. Since the association may reflect a type I multiple endocrine neoplasia (MENI), involvement of other endocrine systems, notably the pituitary gland, should be investigated in the patients and their family. A rise in basal plasma pancreatic polypeptide has been observed in about 50% of cases of familial MEN I (Wermer's syndrome) and appears to be a good index of pancreatic endocrine tumour. When ZES is associated with HPT I, the latter should be treated first for three reasons: (7) lethal acute hypercalcaemia may occur after abdominal surgery; (2) HPT I itself may increase the gastric acid secretion and hypergastrinaemia of the ZES, and (3) parathyroidectomy and medical treatment with gastric antisecretory drugs may postpone the need for total gastrectomy.

Adult↗
PubMed1982

Ranitidine upon meal-induced gastric secretion: oral pharmacokinetics and plasma concentration effect relationships.

1 Ranitidine oral kinetics and plasma concentration-effect relationships upon meal-induced gastric secretion were investigated in normal subjects. Four oral doses of ranitidine (50, 100, 150 or 200 mg) and placebo were tested. 2 Oral ranitidine showed a terminal half-life of about 2 h 25 min. Maximal plasma level was about 240 ng/ml for a 100 mg dose, and occurred about 1 h after dose. From the range of 50 to 200 mg dose, no indication of non-linearity was observed in the drug kinetics. 3 Ranitidine administration resulted in a dose-related reduction in meal-stimulated acid secretion reaching, 46, 70, 82 and 92%, respectively. Mean ranitidine plasma concentrations producing 50 and 80% inhibition of acid secretion were 73 and 180 ng/ml, respectively, with great inter-individual variability. 150 and 200 mg ranitidine oral doses maintained IC50 for at least 4.5 and 5.5 h, respectively. Upon oral administration, ranitidine exerted no effect on gastric emptying of the meal but slightly decreased the gastrin response to the meal.

Adult↗
PubMed1982

Prolonged secretory inhibition during cimetidine treatment in Zollinger-Ellison patients.

In 23 Zollinger-Ellison patients who had been treated continuously with cimetidine for more than 3 months repeated measurements of basal acid output (BAO) were carried out 10-12 h after the last drug dose, to evaluate the prolonged inhibition of gastric acid during continuous cimetidine treatment. Most patients had a markedly prolonged inhibition of BAO after a few weeks of treatment compared with the BAO before cimetidine treatment. The prolonged inhibition became significant after 6 to 12 months of treatment (p less than 0.05). In some patients the prolonged inhibition was transient. In seven patients cimetidine therapy was discontinued for 3 days. Measurement of BAO after 12, 36, and 60 h of withdrawal revealed a marked inhibition lasting more than 60 h in four patients. Determination of plasma cimetidine could not demonstrate any detectable amounts after 12 h of withdrawal. The prolonged inhibition of BAO observed during continuous cimetidine treatment is of significant importance for evaluating secretory data. The phenomenon is still unexplained.

Adult↗
PubMed1982

Effect of pirenzepine on meal-stimulated acid secretion and gastrin release in normal man.

The effect of increasing doses of pirenzepine, a tricyclic compound and new antiulcer drug, on meal-induced gastric acid secretion, gastrin release and gastric emptying of the liquid meal, was investigated in eight healthy volunteers. Gastric acid secretion was assessed using intragastric titration technique. Intra-muscularly administered doses of pirenzepine tested were 0 (placebo), 0.1, 0.25 and 0.5 mg.kg-1. With increasing doses of pirenzepine a dose-related reduction of meal-stimulated acid response was noticed amounting to 53% of control values with the highest dosage. The IC 50 value is close to 200 ng.ml-1. Initial but not total gastric emptying of the liquid protein-meal was slowed by 0.5 mg.kg-1 pirenzepine dose. Gastrin responses to the meal were reduced in a dose dependent manner although to a lesser degree.

Adult↗
PubMed1981

[Major undernutrition after total gastrectomy. Critical analysis of pathophysiological mechanisms. One case (author's transl)].

The authors report on a 66-year-old man who presented with major undernutrition 3 1/2 years after total gastrectomy for gastric lymphosarcoma. This case shows that severe post-gastrectomy undernutrition can still be seen nowadays. It also provides an opportunity to discuss the complex pathophysiology of major deficiency syndromes and underlines the predominant role of inadequate food intake in the pathogenesis of the syndrome.

Aged↗
PubMed1981

Results of surgical management in 92 consecutive patients with Zollinger-Ellison syndrome.

Hospital records and follow-up information on 92 patients with surgically proven Zollinger-Ellison syndrome have been reviewed, and data relating to symptomatology, age and sex incidence, pathologic findings, and early and late results of surgical procedures have been summarized. The postoperative mortality rate was 15%, and was adversely affected by previous peptic ulcer surgery, by the necessity of urgent operation for complications of peptic ulcer, and by employment of a procedure that failed to control acid secretion. Thirteen patients were found to have primary gastrinomas of the duodenum and an additional 13 patients had islet cell hyperplasia without evidence of frank neoplasm; prognosis in these two groups appears to be particularly favorable. Despite the current availability of effective nonoperative measures for control of gastric hypersecretion, surgical exploration is warranted in all patients to determine location and extent of tumor and to attempt to control the ulcer diathesis by resection of tumor. Long-term therapy with H2 receptor antagonists is advised for patients whose hypersecretory state has not been alleviated by tumor resection or whose gastrinoma cannot be removed. Total gastrectomy is still indicated in patients whose tumors are not amenable to resection and who are resistant to, or cannot follow, a rigid medical regimen.

Adolescent↗