AIMS AND BACKGROUND: Littoral cell angioma (LCA) is an uncommon vascular tumor of the spleen recently described and interpreted as the tumoral counterpart of the normally present littoral cells lining the splenic sinus channels of red pulp. The diagnosis of LCA is suggested by a quite characteristic morphology and confirmed by the demonstration of a hybrid endothelial/histiocytic phenotype. METHODS: Four original and previously unreported cases of LCA are presented. All four splenic vascular tumors were investigated by light microscopy and immunohistochemistry for endothelial and histiocytic markers. RESULTS: All four cases were associated with visceral epithelial malignancies (colorectal adenocarcinoma in two cases, renal and pancreatic adenocarcinoma in one case each). One case was also associated with an intracranial tentorial meningioma. CONCLUSIONS: We consider our findings as a novelty and signal the possible existence of a clinical syndrome. Five of a total of 21 previously reported cases in the literature were also described as being associated with other cancers (non-Hodgkin's lymphoma in two cases, two not further specified tumors of the liver and brain, an epithelial ovarian cancer, and a non-small cell lung cancer in one case each). Close follow-up and careful investigation in search of a second visceral neoplasm are strongly recommended in cases of LCA, but further clinical observations and more in-depth genetic and molecular studies are needed before any valid conclusions can be drawn.

Aged↗

PubMedDate not supplied

[Testicular teratoma with meningothelial elements].

A case of a mature adult teratoma of the right testicle in 34-year-old man is reported. Microscopically, well-differentiated gut and respiratory epithelium prevailed in the lesion. There were also epidermis and well-developed skin adnexa. In addition, a focus of a meningothelial cell proliferation containing psammoma bodies was detected. There were also a peripheral nerve and glial tissue adjacent to the meningothelial elements. The meningothelial cells were immunohistochemically positive for EMA and claudin and negative for S-100-protein, cytokeratins (AE1-AE3, CAM5.2), desmin, and chromogranin A. The glial tissue was positive for

Adult↗

PubMedDate not supplied

[Nephrogenic fibrosing dermopathy].

Nephrogenic fibrosing dermopathy is a rare disease with focal dermal thickening. A case is described of a male of 51 years after two renal transplantations for glomerulonephritis. He had a node in the anterior abdominal wall which was removed and studied. Immunohistochemically, there were positive dendritic cells and positive mononuclears, proliferation of dermal fibroblasts.

Dendritic Cells↗

PubMedDate not supplied

[Mucinous tubular and spindle-cell carcinoma of the kidney].

4 cases (2 males and 2 females) of mucinous tubular and spindle-cell carcinoma of the kidney were studied. The patients' age was 43 to 87 years. Microscopically, this tumor comprised two major cell populations. One of them involved spindle cells with a sparse cytoplasm, which were arranged in the fascicular pattern, often resembling low-grade smooth muscle tumors. The other population was small cuboidal cells with round nuclei and an eosinophilic cytoplasm. The mitotic activity was low. Only one tumor had both cell components. The other three tumors were represented by the second type cells. Immunohistochemical staining with avidin-biotin was performed by using cytokeratin, vimentin, SMA, p53, Bcl 2, EMA, and CD10. All cases were stained positively with antibodies to the cytokeratins AE1-AE2 and vimentin. The expression of EMA, Bcl 2, and CK7 was varying in different tumors. Responses to smooth muscle actin, p53, CK20, and CD10 were negative in all cases. Mucinous tubular and spindle-cell carcinoma of the kidney should be differentiated from angiomyolipoma with the preponderance of a leiomyomatous component, renal smooth muscle neoplasms, metanephrotic adenoma, and renal cell carcinoma with sarcomatoid differentiation.

Adenocarcinoma, Mucinous↗