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M Meignan

Publications and source records attributed to M Meignan.

89 records · Page 5Linked to original sources
PubMed1978

[Fluorescent thyroid scanning and intrathyroidal iodine quantification: study in 140 patients (author's transl)].

The system consists of twenty individual sorces of one Ci of 241Am and a high resolution lithium drifted silicon detector. A dual channel analyser permits to measure intrathyroidal stable iodine. The scan requires only 13 minutes and can be made with a very low radiation dose (less than 10 mrads). It provides good quality images and remains available in cases of flooded iodine pools or iodine induced thyrotoxicosis. It is of great interest to follow up subacute thyroiditis and to diagnose autonomous nodules without TSH stimulation. Thyroid stable iodine was measured in vivo in 104 patients. Normal female thyroid glands contained 5,5 +/- 1 mg stable iodine. In hyperthyroidism (10 patients), iodine values are low or elevated. An inverse relationship exists between thyroidal stable iodine and values of T4 or T3.

Adenoma↗
PubMed1978

Complications of total abdominal and spleen irradiation in patients with lymphomas.

Fifty patients with non-Hodgkin's lymphoma were treated with total abdominal irradiation to a dose of 3000 rad by anterior and posterior fields treated the same day. Fourteen patients developed complications, four with intestinal obstruction due to stenosis and three with total or partial intestinal irradiation damage. These bowel complications were only seen in patients who had previously had a laparotomy. The ways of preventing these complications are discussed. We have studied renal function by means of clinical examination, biologic and radiologic investigations, and scanning in 75 patients who have received splenic irradiation to a dose of 4000 rad. With a mean follow-up time of 36 months, this study has shown that there was no significant change in blood pressure or in biochemical measurements. However, at the 17th month, nephrotomograms demonstrated cortical atrophy of the upper role of the kidney; at the 8th month, low uptake in the irradiated area was seen on 197Hg neohydrine scanning and a decrease in renal plasma flow in the left kidney during dynamic studies with Hippuran.

Abdomen↗
PubMed1976

[Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure].

A pharmacokinetic study with high doses of frusemide has been performed in nine patients with acute tubulopathy, treated by hemodialysis. The patients were studied between 6 and 28 days after the beginning of the disease. Renal function was normal before the episode of acute renal shutdown. The diuretic effect of frusemide was closely related to creatinine clearance (Ccr): no effect in anuric cases, moderate effect if Ccr was lower than 10 ml/mn, marked effect if Ccr was higher than 10 ml/mn. no direct relationship could be demonstrated between drug plasma level and natriuresis. Frusemide half-life in plasma was short even in anuric patients, suggesting the existence of an extra renal excretion and/or inactivation pathway. Hence toxic side effects due to drug accumulation should not appear in the recommended 1 g/day regimen.

Acute Kidney Injury↗
PubMedDate not supplied

Assessment of ejection fraction with Tl-201 gated SPECT in myocardial infarction: Precision in a rest-redistribution study and accuracy versus planar angiography.

BACKGROUND: Viability and left ventricular ejection fraction (LVEF) are essential measures for the assessment of myocardial infarction (MI). These 2 variables may be evaluated simultaneously by means of thallium-201 gated single photon emission computed tomography (SPECT); however, the precision and accuracy of LVEF measurements with this isotope remain controversial, particularly in cases of extended perfusion defects and poor count densities. METHODS AND RESULTS: Fifty patients with a history of MI underwent a 20-minute rest and a 4-hour redistribution Tl-201 gated SPECT viability protocol, immediately followed by a technetium-99m planar equilibrium radionuclide angiography (ERNA). On gated SPECT images, various count statistics were calculated, and perfusion was automatically quantified by means of CardioMatch, which provided both the size and severity of MI defects. Rest and redistribution LVEFs were determined from gated SPECT with Germano's algorithm, whereas LVEFs were calculated from ERNA using the manufacturer's software. Mean LVEF values calculated with rest gated SPECT, redistribution gated SPECT, and planar ERNA were 30% +/- 13%, 30% +/- 13% and 33% +/- 13%, respectively. Significant differences between repeated gated SPECT LVEFs were not shown by means of the paired t test. Correlation coefficients were high between 20-minute and 4-hour scans (r = 0.89) and between gated SPECT and ERNA (r = 0.88 and r = 0.92 at 20 minutes and 4 hours, respectively). Additionally, close agreement between gated SPECT and ERNA was shown by means of the Bland-Altman plot, despite an underestimation of 3 units. Finally, neither the technical conditions (count density, heart rate, lung uptake, etc) nor the perfusion alteration (size, severity, redistribution) appeared to interfere with the precision and accuracy of gated SPECT LVEF measurement. CONCLUSION: Tl-201 gated SPECT is a precise method for assessing LVEF within the same patient at 4-hour intervals, even with a substantial count decay, and it gives accurate results compared with planar ERNA, even in the case of large perfusion defects.

Adult↗
PubMedDate not supplied

[The value of scintigraphic imaging with 99mTc-MIBI for the diagnosis of gliomas].

Imagery is the only possibility of early glioma diagnosis. Both the gravity of the evolution and the bad prognostic, through all CNS tumors, justify the necessity to asses new techniques in order to improve glioma imagery. From this point of view, cerebral tomoscintigraphy has developed, its usefulness depending highly on the radiotracer tumoral specificity. One of these tracers, 99mTc MIBI, has been found to be uptake in glioma malignant cells, in relation with their viability and even malignity. In our study, -14 cerebral tomoscintigraphies have been realized on patients with glioma (initial or recurrent tumor), after 20 mCi 99mTc MIBI i.v. doses. The results are in correlation with the histologic glioma grade: high grade astrocytoma has positive images, but low grade astrocytoma doesn't. In conclusion 99mTc MIBI glioma tomoscintigraphies can be useful in their initial or recurrent diagnosis; the uptake tracer intensity being correlated with the histologic tumoral pattern, 99mTc MIBI SPECT could make possible a better localization of highest malignity tumoral points, in further biopsies.

Adult↗
PubMedDate not supplied

99mTc MIBI in neurofibromatosis imaging diagnosis: case report.

99mTc MIBI has been shown to accumulate in different cancer cells types, in vitro and malignant tumours in vivo, making evidence of the scintigraphic diagnostic of them. We report two cases of neurofibromatosis type I, which has realised high levels of 99mTc MIBI uptake, primary to all chemo- or radiotherapy. Only certain zones of tumorous localisation have been seen, but a relation with the lesion histology was not really established. In conclusion, 99mTc MIBI scintigraphy may be usefull in the investigation of type I neurofibromatosis.

Adolescent↗
PubMedDate not supplied

[Complementary scintigraphic examinations (99mTc-MDP, 99mTc-MIBI and Octreoscan) in breast neoplasm assessment].

Scintigraphic imagery was used in breast carcinoma mostly for the bone metastases screening, using 99mTc-MDP. Others radiopharmaceuticals can be used to visualize either the primary tumour or the soft tissues metastases. It's mainly the case of 99mTc-MIBI, and also of some somatostatin analogues, like Octreoscan. This case report of a patient with a T3N1M+ breast adenocarcinoma having different secondary sites represent also a prove of the complementarity of these explorations, which give the possibility of diagnostic and therapeutic evaluation and, in the same time, the possibility of a better understood of the metastasizing mechanism.

Adenocarcinoma↗