Biomedical subjects
Publications and source records attributed to M Megahed.
The simultaneous occurrence of blue and naevocytic naevus in the same lesion is rare and can be difficult to diagnose. Precise differentiation from nodular melanoma may only be possible by histopathological examination. Agminated blue naevi, first described by Upshaw et al. [25] in 1947, are also rare. It is important to differentiate these lesions from nodular melanoma with satellite metastases. We describe two patients with such unusual blue naevi.
We report a 13-year-old boy with localized Langerhans cell histiocytosis. The lesion was restricted to the skin of the mons pubis and clinically resembled lichen aureus. Histopathologic and electron microscopic examinations of a skin biopsy specimen of the lesion showed typical features of Langerhans cell histiocytosis. Extensive examination revealed no other organ involvement.
We present a 36-year-old woman with pemphigus erythematosus that showed histopathologically supra-basilar acantholysis and lichenoid tissue reaction. To our knowledge this is the first case of pemphigus erythematosus with such unusual histopathologic presentation to be reported.
A 57-year-old man suffering from persistent light reaction with photocontact allergy to musk ambrette and contact allergy to fragrance mix was evaluated. A lowered minimal erythema dose to UV-B (MED-UV-B) was seen. Reactions to long-wave UV-A and visible radiation were normal. A skin biopsy from one MED-UV-B, taken 24 h after irradiation, showed acute spongiotic dermatitis.
In a six-year-old girl with linear IgA dermatosis of childhood there were lesions with typical rosette like configuration, crusted erosions and isolated bullae on apparently normal skin. The histopathology revealed subepidermal blister and superficial perivascular lymphohistiocytic infiltrate with many neurophils and some eosinophils. Direct immunofluorescence examination showed linear deposits of IgA along the basal membrane zone. Circulating antibodies were absent. Therapy with dapsone in a dose of 25 mg/day was effective.