Congenital agminated segmental naevi.
We report a 39-year-old woman with agminated segmental naevi on the right side of her face. The lesions were present at birth, and she had no other congenital abnormalities.
Adult↗
Biomedical subjects
M Megahed
Publications and source records attributed to M Megahed.
Provocation of porphyria cutanea tarda by KUVA-therapy of vitiligo.
Therapy with khellin and UVA irradiation (KUVA) is a therapeutic approach to vitiligo. Little is known about the photobiological properties of khellin and its long-term side-effects after prolonged administration. A 47-year-old woman suffering from acral vitiligo since the age of 3 is reported, who developed blisters on hands and fingers during KUVA-therapy. Laboratory findings were consistent with hereditary porphyria cutanea tarda. Electron microscopic examination of a blister revealed clefting below the basement membrane. It is proposed that khellin in some way provoked the porphyria cutanea tarda in this patient.
Basement Membrane↗
Epidermolysis bullosa acquisita--successful treatment with colchicine.
The treatment of epidermolysis bullosa acquisita (EBA) is difficult and often disappointing. We report on the successful treatment of two EBA patients with colchicine. The drug was administered orally at an initial dose of 2 mg/day. After 2 weeks of therapy a dramatic improvement was observed. Most of the cutaneous and buccal mucosal lesions had healed and both of the patients were able to go about their normal daily activities. In the first patient the disease was refractory to dapsone alone or combined with steroids. In the second patient no other treatment was tried. After 6 months a maintenance dose of 1 mg/day colchicine was given. The disease had remained stable in both patients at the time of writing for more than 8 months. No side effects were observed. We suggest that colchicine may be a helpful and safe drug for patients with EBA.
Administration, Oral↗
[Spinocellular cancer in lichen sclerosus et atrophicus of the vulva].
We report on a 78-year-old woman with a 47-year-history of lichen sclerosus et atrophicus of the vulva on which squamous cell carcinoma developed. The lesion started as a small nodule that increased gradually in size and became eroded. The tumour and the inguinal lymph nodes on both sides were excised. Physical examination, chest X-ray and sonography of the abdomen 15 months later showed no local recurrence or distant metastases. Lichen sclerosus et atrophicus of the vulva should be considered a possible precancerous condition.
Aged↗
[Simultaneous occurrence of extra-abdominal fibromatosis and post-traumatic keloid].
The report deals with the clinical features of a 26-year-old man with the extraabdominal form of deep fibromatosis, which became manifest at the age of 18 years as acute ileus caused by diffuse intraabdominal fibromatous tumours. In the later course of the disease extensive fibromatous lesions developed, mainly at the skin. In addition, multiple keloids occurred after excision or after negligible traumas. The pathogenetic events of the clinical picture described may be linked to the activation of mesenchymal cells leading to the generation of either fibromatous tumours or posttraumatic keloids.
Adult↗
[Angioimmunoblastic lymphadenopathy accompanied by Duhring disease-like lesions ].
A 62-year-old female patient presented with bullous, intensely itching cutaneous lesions, which clinically and histopathologically resembled dermatitis herpetiformis (Duhring's disease). Therapy with DADPS was unsuccessful. Because of associated cervical lymph node enlargement and splenomegaly, a lymph node biopsy was taken. Histopathology of a lymph node and of the bone marrow confirmed the diagnosis: angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma. Intensely pruritic associated skin eruptions are typical for this peculiar kind of lymphoma. These skin lesions are due to inflammatory cells and not to neoplastic infiltrations. This case report is the first report of AILD with bullous skin lesions to appear in the literature.
Biopsy↗
[Amelanotic polypoid malignant melanoma of the balloon cell type].
We describe a 59-year-old woman with amelanotic polypoid balloon cell melanoma. Physical examination showed exophytic erythematous tumour simulating a basal cell carcinoma or an adnexal tumour. Histopathology revealed a polypoid tumour that was composed mainly of balloon cells in sheets and nests. Examination 37 months after excision of the tumour with 3 cm safety margins disclosed no evidence of enlarged lymph nodes or cutaneous metastases. Metastases to internal organs could not be assessed because the patient repeatedly refused further examination for staging. To our knowledge our patient is the first case of amelanotic polypoid balloon cell melanoma to be reported in the German literature.
Antigens, Neoplasm↗
Acquired relapsing self-healing Blaschko dermatitis.
We describe a 44-year-old woman who had a unilateral relapsing linear dermatosis for 12 years. The lesions consisted of erythematous, discrete and grouped papules and papulovesicles that were localized to the left side of the upper and lower limbs, chest, abdomen, and back. They were distributed along Blaschko's lines. There was also a diffuse erythematous scaly hyperkeratosis of both palms. The lesions healed spontaneously. Examination of biopsy specimens from the back and the left palm revealed acute and subacute spongiotic dermatitis, respectively. This dermatosis was first described by Grosshans and Marot in 1990 and termed "Blaschkite de l'adulte." Because the disease is acquired, relapsing, heals spontaneously, follows Blaschko's lines, and is characterized histopathologically by a spongiotic dermatitis, we propose the term "acquired relapsing self-healing Blaschko dermatitis."
Adult↗
Palisaded encapsulated neuroma (solitary circumscribed neuroma). A clinicopathologic and immunohistochemical study.
Although palisaded encapsulated neuroma was first described over 20 years ago, it has received little attention. We present the clinical, histopathologic, and immunohistochemical features of 10 cases of this entity. The cases were studied by routine light-microscopic examination and immunohistochemistry using the avidin-biotin-peroxidase technique. Clinical information and follow-up data were obtained from the hospital records. The lesions were solitary, asymptomatic, skin-colored papules that were located on the faces of patients who ranged in aged from 37 to 66 years (average, 52 years). The female to male ratio was 1:1. None of the patients had von Recklinghausen's disease, and none of the lesions recurred after excision. Histopathologically, the tumors were well circumscribed and situated predominantly in the dermis. They were encapsulated and composed of spindle cells arranged in interlacing fascicles. The tumor cells were positive for S-100 protein. The capsule was composed of flattened, elongated cells that showed positivity for epithelial membrane antigen (EMA).
Adult↗
Plexiform schwannoma.
We report the clinical, histopathologic, and immunohistopathologic features of two cases of plexiform schwannoma. This rare benign tumor is worthy of recognition because it can be misdiagnosed as plexiform neurofibroma. Differentiation from plexiform neurofibroma is important because the latter is pathognomonic of von Recklinghausen disease and carries a significant risk of malignant transformation. Plexiform schwannoma is, in contrast, not necessarily associated with von Recklinghausen disease and malignant transformation has never been observed.
Adult↗
Cellular schwannoma.
We report on the clinical, histopathological, and immunohistochemical features of a case of cellular schwannoma. This rare benign nerve sheath tumor merits recognition because it frequently shows moderate nuclear atypia and mitotic activity leading in some instances to the false diagnosis of sarcoma.
Adult↗
Histopathological variants of neurofibroma. A study of 114 lesions.
Although neurofibroma is a relatively common tumor, some histopathologic variants are so rare that they are not well known. In a study of 130 neural cutaneous tumors seen between 1986 and 1991 in the department of dermatology at the University of Heinrich-Heine, we identified 114 neurofibromas of different types. We present herein the histopathological features of these tumors. The differentiating features from other neural tumors--melanocytic or mesenchymal tumors that display "neuroid" features--are also discussed. also discussed.
Adipose Tissue↗
[Dermatoses in pregnancy].
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Diagnosis, Differential↗
Papillary eccrine adenoma. A case report with immunohistochemical examination.
The case of a 52-year-old woman with papillary eccrine adenoma is reported. The lesion presented clinically as a slowly growing nodule on the dorsum of the left foot. Histopathologically, the tumor was composed of multiple, dilated tubular structures lined by two or more layers of epithelial cells. The inner cell layer formed intraluminal papillary projections in some of the tubules. Most of the lumina were filled by eosinophilic granular material. Immunohistochemical examinations that use the avidin-biotin method showed immunoreactivity to S-100 protein, carcinoembryonic antigen, and epithelial membrane antigen. These findings support the hypothesis that papillary eccrine adenoma differentiate toward the secretory epithelium of sweat glands.
Antigens, Neoplasm↗
Acantholytic acanthoma.
In 1988, Brownstein described a previously unrecognized benign acanthoma, the acantholytic acanthoma. We report an additional case seen on the arm of a 61-year-old man.
Basal Cell Carcinoma↗
[Polypoid malignant melanoma. An aggressive, seldom observed variant of nodular malignant melanoma].
We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. Physical examination showed an eroded pedunculated nodule approximately 2.5 x 3 cm in size. Histopathology revealed a pedunculated, sharply demarcated tumour with an eroded surface; it was composed of atypical melanocytes in sheets and nests. Physical examination 11 months after excision of the tumor with 3-cm safety margin disclosed no evidence for enlarged lymph nodes or cutaneous metastases. No metastases were seen on computer tomography. To our knowledge, this patient represents the first case of polypoid melanoma reported in the German literature.
Biopsy↗
[Angioimmunoblastic lymphadenopathy with cutaneous manifestations in a 13-year-old girl].
We describe a 13-year-old girl with angioimmunoblastic lymphadenopathy. The patient's main symptom was a generalized pruritic maculopapular rash located mainly on the upper and lower limbs. In addition to the skin lesions, physical examination revealed enlarged cervical, axillary and inguinal lymph nodes. There were also hepatosplenomegaly and oedema of both hands. Blood examination showed elevated ESR, haemolytic anaemia, polyclonal hypergammaglobulinaemia and eosinophilia. Virus serology including HIV I and II and HTLV I was negative. Histopathological examination of a lesional skin biopsy showed superficial and deep dermal infiltrate extending into the subcutaneous tissue. The infiltrate consisted of lymphocytes, some with atypical nuclei, histiocytoid cells, and few eosinophils. There was also proliferation of dermal blood vessels. Examination of an enlarged cervical lymph node disclosed typical histopathological features of angioimmunoblastic lymphadenopathy and confirmed the diagnosis.
Administration, Topical↗
[Neurothekeoma. A light and electron microscopy, histochemical and immunohistochemical study].
We report a 37-year-old man with neurothekeoma that developed on the tip of the nose. Histopathological examination revealed a lobulated myxoid dermal tumour. The tumour cells were spindle-shaped or bizarre configuration. In the lower part of the dermis the lesion contained abundant cells simulating glomus tumour or melanocytic naevus. Staining with S-100 protein, epithelial membrane antigen (EMA), neuron-specific enolase (NSE) and desmin were negative. The matrix of the tumour was positive for Alcian blue and periodic acid-Schiff (PAS). Electron microscopic examination showed that the lesion was composed of dendritic cells separated by abundant glassy matrix and varying amounts of collagen fibres. Some of the cells looked like fibroblasts, and others like perineurial cells. The histogenesis of the tumour is discussed with particular attention to histochemical, immunohistochemical, light and electron microscopic findings.
Adult↗