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Biomedical subjects

M Matsuda

Publications and source records attributed to M Matsuda.

At least 1,315 records · Page 73Linked to original sources
PubMed1983

Properties of red blood cell after multiday exposure to 31 ATA.

Hematologic changes, osmotic fragility of red cells, and lipid contents of plasma and red blood cells were determined during the course of a 14-day dry saturation dive at 31 ATA (SEADRAGON IV). Increases in hematocrit and red blood cell count were observed during the early period at 31 ATA, which was attributed to hemoconcentration resulting from a diuresis. The osmotic fragility of red blood cells decreased slightly during the course of the experiment, but the changes were not related to the atmospheric pressure. Cholesterol and phospholipid content of the red blood cell and the plasma showed slight, insignificant daily variations independent of pressure. However, the same overall correlation was observed between the osmotic fragility and the phosphatidylcholine content of red blood cells and between the osmotic fragility and the total cholesterol level in the plasma, at both 1 ATA and 31 ATA. These correlations revealed an intimate relationship between the cell fragility and lipid composition of the cell membrane and the plasma within intra- and interindividual variations during the course of the experiment, but did not indicate any significant alteration of red blood cell function by the prolonged exposure to 31 ATA helium-oxygen environment. These results indicate that the exposure of human divers to 31 ATA for 14 days does not seem to induce any irreversible chemical changes in the red blood cell.

Adult↗
PubMed1983

Psychotic symptoms in childhood epilepsy--an electroencephalographic study.

To investigate the significance of EEG findings relating to the appearance of psychic symptoms in epileptic children, a clinicoelectroencephalographic study was undertaken on 15 cases with psychotic episodes. 1) Psychotic episodes with hallucination and/or illusion were observed, though rarely, in childhood epilepsy. These seemed liable to occur in temporal lobe epilepsy. 2) Three of four patients in the hallucination and illusion group showed frequent epileptic discharges. However, no distinct relation existed between seizure discharges and psychotic episodes. 3) Eight of 11 patients in the dysphoria and excitement group were secondary generalized epilepsy. 4) In the dysphoria and excitement group, psychotic episodes occurred either as a result of the increase in epileptic discharges or conversely as a result of the suppression of epileptic discharges. The former was more frequent. Epileptic discharges tended to be suppressed in the Lennox syndrome and allied conditions relating to psychotic episodes. 5) A forced normalization-like phenomenon mostly resulted from the marked suppression of diffuse slow spike-waves. However, a complete suppression of epileptic discharges was not always noted.

Adolescent↗
PubMed1983

[Perineural invasion of pancreas head carcinoma].

Perineural invasion of carcinoma is of considerable interest especially in the pancreas, because this organ is adjacent to the main autonomic plexuses of the abdomen. The present study was based upon 14 cases of primary carcinoma of the pancreas head in which total pancreatectomy with extensive dissection of the regional lymph nodes and autonomic plexuses was performed. Information concerning perineural invasion was obtained from histological specimens of the pancreas, lymph nodes and autonomic plexuses. Carcinomatous involvement of nerves was observed in all 14 cases within parenchyma of the pancreas head, but never found in the body and tail. Perineural extension of carcinoma to the regional autonomic plexuses was observed in 9 cases, which included the pancreatic capital plexus in 8 patients, superior mesenteric plexus in 3, celiac plexus in 2 and plexus on the common bile duct in 2 patients. This manner of invasion had no relationship with behaviour of lymph node metastasis. Thus, invasion and extension along the autonomic nerves by carcinoma of the pancreas were more common than usually recognized. Extensive dissection of the regional autonomic plexuses should be performed to increase the possibilities of a curative procedure.

Adenocarcinoma↗
PubMed1983

[Experimental ARDS and its prevention].

Our retrospective study on the postoperative ARDS and DIC in surgical patients, during the period of April, 1974 through October, 1980, revealed the presence of DIC in all the 13 patients with ARDS. Although ARDS was not found to have developed in all the patients with DIC, the number of which was 28, we speculated that DIC might have underlain ARDS, on the basis of an observation that the parameters for respiratory functions had changed nearly in parallel with those for the blood coagulation and fibrinolysis. Our animal study in dogs seems to support our concept, which showed a good correlation between the severity of respiratory functions and that of consumption coagulopathies. By giving animals a variety of chemical agents and drugs prophylactically in order to inhibit platelets or blood coagulation or both, we clearly showed that respiratory functions were significantly well preserved when compared with the control group. Thus we would like conclusively remark that DIC may underly and trigger ARDS under certain postoperative conditions, although not all the contributory factors have been clarified at this stage of investigation.

Animals↗
PubMed1983

Circulating cytotoxic anti-RCC antibody responses in renal cell carcinoma patients.

The circulating anti-RCC cytotoxic antibodies of eighteen RCC patients, preoperatively, and one inoperable case were studied by 51Cr release CDC and ADCC assays, using the cultured human RCC cell line, OUR-10. Circulating cytotoxic anti-RCC antibodies were detected in eight patients as CDC antibodies. The patients with a low pathological grade had a significantly higher percentage (P less than 0.05) of positive antibody responses.

Adenocarcinoma↗
PubMed1983

[Contrast echocardiography of the left heart by intravenous injection of perfluorochemical emulsion].

We evaluated a new method of contrast echocardiography of the left heart utilizing the intravenous injection of perfluorochemical emulsion (PFC emulsion: Fluosol-DA 20 W/V%: Green Cross Corp), which was prepared as artificial blood. Observations were made in 18 open-chest dogs. To assess the possibility of detection of mitral valve regurgitation and myocardial perfusion by this method, a small series of experiments were made. Results were as follows: Following the appearance of contrast echoes in the right heart after the injection of PFC emulsion (10 ml) into the inferior vena cava, the left heart contrast echo images were clearly obtained in 16 of the 18 dogs, and they were visible but weak in the remainder 2. The solution of surfactants (Pluronic F-68, yolk phospholipids, and glycerol), which were added to Fluosol-DA, was also used as contrast agent in 6 dogs. The left heart was also opacified by contrast echoes after intravenous injections. However, the density of the left heart contrast echoes appeared lower, as compared with that after the injection of PFC emulsion. When oxygen (95%) was mixed in PFC emulsion or inhaled through the intratracheal tube, the left heart contrast images were slightly enhanced. In 4 of 6 dogs with surgically created mitral valve regurgitation, systolic contrast echoes in the left atrial cavity were detected on the M-mode echograms after the intravenous injection of PFC emulsion (15 ml). These echoes appeared to move across the mitral valve from the left ventricle to the left atrium or away from the mitral valve in the left atrium.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1983

[Isoproterenol infusion stress two-dimensional echocardiography in detecting coronary artery disease].

Dynamic exercise two-dimensional (2-D) echocardiography has been utilized as a valuable method in the diagnosis of coronary artery disease (CAD). However, there are some limitations in this technique including inability to apply for patients whose physical capacity is limited. Moreover, appropriate echocardiographic recordings are frequently difficult because of bodily movements and/or hyperventilation during exercise. In order to overcome these limitations, we examined whether isoproterenol (ISP) infusion stress 2-D echocardiography could detect transient LV asynergy or not. The subjects consisted of 19 cases with angina pectoris (AP), 16 with old myocardial infarction (OMI), nine with atypical chest pain syndrome and six with miscellaneous heart disease. ISP stress test was performed prospectively as follows: ISP was infused at a rate of 0.02 microgram/kg/min until anginal pain occurred or significant ST depression (elevation) developed. Real time 2-D echocardiograms were obtained in the short-axis or apical RAO views of the LV before and every one minute during ISP infusion test. Coronary artery stenosis was considered to be present if the narrowing was 50% or more in the luminal diameter. The results were as follows: Adequate echocardiographic recordings were obtained in 86.1% of LV segments at rest, and in 82.2% during ISP infusion. Echocardiographic recordings during ISP infusion were feasible in almost all cases. LV wall motion abnormalities were detected in 12 (86%) of the 14 subjects with OMI and two (29%) of the seven subjects with AP at rest, while induced or exaggerated in nine (64%) of the 14 subjects with OMI and all of the 7 subjects with AP during ISP infusion. On the other hand, LV wall motion remained entirely normal during ISP infusion in 11 (92%) of the 12 subjects without CAD. In 4 (40%) of these 10 subjects without CAD, electrocardiographic judgements were positive in the ISP stress test. None had hazardous arrhythmias or severe anginal pain. ISP infusion stress 2-D echocardiography possessed feasibility of detecting LV wall motion abnormalities because this method could exclude difficulty of recordings due to bodily movements and/or hyperventilation seen in exercise echocardiography. Compared with ISP stress electrocardiography, 2-D echocardiography seemed to be superior with respect to the specificity in detecting CAD. In conclusion, ISP stress echocardiography is a safe and useful method in the diagnosis of CAD.

Adult↗
PubMed1983

[Evaluation of aspiration cytology in the diagnosis of mammary tumors].

Aspiration cytology was performed in 1603 patients with breast lesions. Of 298 histologically confirmed malignant tumors, 234 (78.5%) had a concordant cytologic diagnosis. In 75% of 24 patients infiltrating cancer of 1.0 cm or less in greatest dimension, a correct diagnosis was obtained. The ratio of true-positive cases was higher and that of suspicious and false-positive cases lower, in aspiration cytology compared to mammography or echography. Cytologic diagnosis showed 4.7% false-positive results in this series. Atypical cells from intraductal proliferation and low malignant cancer cells were sometimes difficult to distinguish. In patients with such atypical cells, surgical biopsy was required. No difference in the 5-year survival was found between breast cancer patients who had aspiration cytology and their matched controls. Therefore, this method is very safe and is considered to be the most valuable in the correct diagnosis of breast cancer.

Biopsy, Needle↗
PubMed1982

Distribution of fibronectin in plasma and liver in liver diseases.

We measured the concentration in plasma of fibronectin, a recently characterized high molecular weight glycoprotein, in patients with various liver diseases. We found that it was significantly increased in acute hepatitis, fatty liver, all types of chronic hepatitis and liver cirrhosis without clinical evidence of ascites. Only in patients at the decompensated stage of liver cirrhosis, i.e. patients with clinical evidence of the presence of ascites, was it significantly reduced. Based on the immunohistochemical study on biopsy specimens of the liver using anti-human fibronectin antiserum, we suggest a possible correlation of the elevated plasma fibronectin to the wide distribution of specific fluorescence associated with the fibrillar structures in necrotic areas, expanded portal areas or thick fibrous septa in the liver diseases. Accelerated catabolism of plasma fibronectin mediated by increased fibrinolytic activity may contribute to the decrease in the level of plasma fibronectin in severe liver cirrhosis.

Alanine Transaminase↗
PubMed1982

Effects of surfactants on the aqueous stability and solubility of beta-lactam antibiotics.

Studies were undertaken to elucidate the interaction between beta-lactam antibiotics and surfactant micelles and to examine the effects of surfactants on their aqueous stability and solubility. The apparent binding constant of the micelle-antibiotic complex was determined as a function of the solution pH at 37 degrees and mu = 0.15 by the dynamic dialysis method and hydrolysis study. In the interaction with nonionic and anionic micelles of polyoxyethylene-23-lauryl ether (I) and sodium lauryl sulfate (II), large differences were noted in the binding constants between the undissociated and ionized species of penicillins. However, the cationic surfactants, cetyltrimethylammonium bromide (III), showed no significant difference in the binding constants for both species. Acid degradation of penicillins was protected in micellar solutions of I and III but was facilitated in micelles of II. The surfactants exerted no influence on the neutral degradation of the antibiotics used. The solubilization of penicillin V acid by micelles of I was studied at pH 2.0 and 35 degrees. The solubility increased threefold in the presence of 10 mM I.

Anti-Bacterial Agents↗
PubMed1982

Superior sagittal sinus thrombosis followed by subdural hematoma.

A case of superior sagittal sinus thrombosis followed by a subdrual hematoma is reported. A 33-year-old woman, who presented with serious neurological deficits, made a remarkable recovery with mild residual. She had a thin subdural fluid collection, which eventually developed into a subdural hematoma. After evacuation of the hematoma, she had no neurological deficits. Treatment of cerebral venous and dural sinus thrombosis is discussed.

Adult↗