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Biomedical subjects

M Matsuda

Publications and source records attributed to M Matsuda.

At least 829 records · Page 46Linked to original sources
PubMed1990

Magnetic resonance imaging of large and giant intracranial aneurysms.

Twelve large or giant intracranial aneurysms were studied with magnetic resonance (MR) imaging, and the findings were compared with those from computed tomographic (CT) scanning. Characteristic MR features of such aneurysms are: round, extra-axial mass with hypointensity rim; signal void, paradoxical enhancement, or even-echo rephasing due to blood flow; and laminated, eccentric thrombus with increased signal intensity when fresh, perianeurysmal hemorrhage occurs in the acute or subacute stage after aneurysmal rupture. MR imaging, however, often fails to identify or characterize the area of calcification. For the diagnosis of large or giant intracranial aneurysms, MR imaging is apparently superior to CT scanning in differentiating aneurysms from tumors, delineating the blood flow and intraluminal thrombus, and detecting the exact size of the aneurysm. It may also provide useful information concerning the growth mechanisms of aneurysms with or without thrombus formation.

Adult↗
PubMed1990

[Clinical statistics of germinal testicular cancer].

We experienced a hundred and fifty-six cases of germinal testicular cancer at Osaka University Hospital from 1957 to 1988. Histologically, 114 cases (73.1%) were simple type, and 42 cases (26.9%) were mixed type. Eighty cases (51.3%) were seminoma, and 76 cases (48.7%) were non-seminoma. All patients of seminoma were over 20 years of age, and the mean age was 36.1 years. Non-seminoma cases were distributed as to with two peaks, one in 0 to 4 year-old and another in 20 to 39 year-old, and the mean age was 22.9 years. The seminoma/non-seminoma ratio as to clinical stages were 63 cases/48 cases in Stage 1, 6/9 in Stage 2A, 5/6 in Stage 2B and 6/13 in Stage 3. The five-year survival rate (by Kaplan-Meier's method) was 98.4% for Stage 1 (71 cases), 72.7% for Stage 2A (11 cases), 0% for Stage 2B (4 cases) and 20% for Stage 3 (5 cases) between 1957 and 1978, and 100% for Stage 1 (40 cases), Stage 2A (4 cases), Stage 2B (7 cases) and 26.8% for Stage 3 (14 cases) between 1979 and 1988. The five-year survival rate of 20 advanced cases treated mainly by PVB regimen was 100% for Stage 2 (6 cases) and 68.6% for Stage 3 (14 cases). Five advanced cases containing choriocarcinoma elements were treated by PVB regimen and its two-year survival rate was 40.0%, which was statistically worse than that (86.8%) of other histological types (p less than 0.05).

Adolescent↗
PubMed1990

Gamma interferon production and two-color fluorescence flow cytometry analysis of peripheral blood mononuclear cells in allogeneic bone marrow transplant recipients.

Gamma interferon (gamma-INF) production was studied and two-color fluorescence flow cytometry analysis was done on the peripheral blood mononuclear cells (PBMC) in allogeneic bone marrow transplant recipients. Gamma INF was not detected in any patients within a year after transplantation whether PBMC was stimulated with PHA or not. A year after transplantation, gamma-INF was produced in the normal level in the stimulated and unstimulated PBMC. The number of suppressor-inducer T cells (CD4+2H4+) was decreased and that of suppressor T cells (CD11+CD8+) was normal. The numbers of helper-inducer T cells (CD4+4B4+) and helper T cells (CD4+2H4-) were normal. The numbers of activated helper-inducer T cells (CD4+HLA-DR+) and suppressor-cytotoxic T cells (CD8+HLA-DR+) were elevated. In the NK cells, Leu7+ CD16-cells were elevated, whereas Leu7+CD16+ cells and Leu7-CD16+ cells were normal. Leu7+CD8+ cells were elevated. These results indicated immunodeficiency after transplantation.

Bone Marrow Transplantation↗
PubMed1990

[Leiomyoma of urinary bladder: report of a case].

A case of leiomyoma of the urinary bladder in a 46-year-old woman is reported. The patient was referred to us because of incidental finding of a mass in the bladder. Cystoscopy revealed a protruding tumor covered with normal-appearing urothelium on the right posterior wall of the bladder. The tumor was well-demarcated from adjacent organs on echography and computed tomographic scan. Transurethral biopsy revealed a bladder leiomyoma. Partial cystectomy was performed. The patient is now apparently free of disease 7 months after the operation.

Biopsy↗
PubMed1990

Amelanotic malignant melanoma of the esophagus: case report and review of the literature.

A case of amelanotic malignant melanoma of the esophagus in a 76-year-old woman is reported. A whitish polypoid tumor, measuring 3 x 2 x 2.7 cm, surrounded by black pigmented mucosa, was detected in the middle intrathoracic esophagus. The tumor showed a lobulated surface lined by squamous cell layer, and had epithelioid and polyhedral cells forming alveolar clusters. Melanin pigments or stainability for the dihydroxyphenylalanine (DOPA) reaction were only observed in a few tumor cells. Junctional changes and mucosal melanosis, however, were found freely in the mucosa around the tumor. Many tumor cells showed a strongly positive immunohistochemical reaction for neuron specific enolase (NSE) and S100 protein. The patient died of widespread metastases six months after surgery. Further, a review of 106 reported cases of primary esophageal malignant melanoma, including 29 autopsies, was made; the melanomas were found to include 10 of amelanotic type, eight of which had been misdiagnosed at biopsy. Junctional changes could be found in the mucosa over or around the tumor, in four cases, and mucosal melanosis in one. Lymph node metastasis was the most frequently observed development at autopsy regardless of whether the tumor was amelanotic or melanotic. For correct diagnoses of melanomas of the amelanotic type, peripheral mucosal findings, such as junctional changes or melanosis, should be helpful; and, in order to obtain a good prognosis, a careful resection of the regional lymph nodes could prove valuable.

Aged↗
PubMed1990

[Association of indoor air pollution and passive smoking with lung cancer in Osaka, Japan].

A hospital-based case-control study was conducted at 8 hospitals in Osaka in order to clarify risk factors among non-smoking women. A total of 129 lung cancer cases and 519 controls were investigated. An elevated risk was observed for women who had used wood or straw as cooking fuels at 30 years of age. Maternal smoking in childhood also seemed to raise the risk. No elevated risks were observed for husband smoking and use of heating apparatus so far.

Air Pollution↗
PubMed1990

[Retroperitoneal lymph node dissection for testicular tumor with renal autotransplantation: a case report].

A case of testicular tumor (embryonal cell carcinoma with choriocarcinoma) in a 42-year-old man treated with renal autotransplantation is presented. After four courses of chemotherapy (carboplatin, vinblastine and bleomycin), we performed retroperitoneal lymph node dissection. At the operation, one of the swelling lymph nodes involved left renal artery completely, so we performed left renal autotransplantation and promoted more effective lymph node dissection. After the operation, renal function was impaired but returned completely in a short time. Autotransplantation provides excellent bench visualization of renal lesions and stable graft function. Therefore, this procedure should be taken into consideration when nephrectomy cannot be avoided.

Adult↗
PubMed1990

Relationship of corneal endothelial morphology to diabetic retinopathy, duration of diabetes and glycemic control.

Using specular microscopy and computer-assisted morphometry, the morphologic features of the corneal endothelium were evaluated in three groups of patients with type II diabetes mellitus: 20 patients without diabetic retinopathy, 24 with background retinopathy, and 26 with proliferative retinopathy. When compared to age-matched nondiabetic controls (30 patients), all diabetic groups had similar endothelial cell densities but demonstrated significant increases in cell size and shape variability (pleomorphism). However, there was no significant difference in the degree of these endothelial changes among the three diabetic groups. Moreover, none of the endothelial morphologic parameters was found to correlate with the duration of diabetes or glycemic control, as estimated from glycosylated hemoglobin (HbA1) concentrations.

Adult↗
PubMed1990

[Occlusion of basilar artery in a 7-year-old boy].

A case of occlusion of basilar artery in a boy aged 7 years was reported. Compared with CT, MR imaging was more valuable for the early diagnosis of this disease. SPECT with IMP was thought to be useful in evaluating cerebellar circulation. ABR revealed brain stem abnormalities that could not be detected by neuroradiological techniques.

Brain Stem↗
PubMed1990

[Insufficient accommodation in patient with keratoconus].

The accommodation response in 10 unoperated patients with keratoconus (mean, 28.3 years) and 10 age-matched normal individuals (mean, 25.8 years) was examined. Using infrared high-speed optometer and iriscorder, quasistatic accommodation and concomitant pupillary response were simultaneously measured by controlling a fixation target for accommodation with a microcomputer. The amplitude of the accommodation response was markedly lower in patients with keratoconus (2.8 +/- 1.4 Diopter) than in controls (4.7 +/- 1.3 Diopter: p less than 0.005). The maximum pupillary responses during far to near accommodation was also significantly decreased in the keratoconus group (0.25 +/- 0.24) when compared with controls (0.56 +/- 0.15; p less than 0.001), despite no statistical difference in pupillary size in the far point between the two groups. The above two pathologic parameters were not found to correlate with the severity of keratoconus. These results suggest that some predisposing abnormalities may exist in the iris and ciliary body of patients with keratoconus, which may be responsible for a paretic pupil that occasionally occurs after corneal transplantation in these patients.

Accommodation, Ocular↗
PubMed1990

[Clinical effect of LM-001, prostaglandin synthetic inhibitor, on pain from urinary tract stone and vesical urgency after operation of the bladder or prostate].

Clinical effect of LM-001, a prostaglandin synthetic inhibitor developed from a drug delivery system, was evaluated in 54 patients with pain from urinary tract stones (stone pain) and 32 with vesical urgency after an operation on bladder or prostate. LM-001, felbinac ethyl incorporated in lipid microsphere, wes intravenously administered at the onset of stone pain or vesical urgency. Of 54 with stones and 32 with urgency, 53 and 29 were eligible for response, respectively. The symptoms improved or disappeared in some cases just after the administration and in the majority of patients within 15 minutes, in 49 of 53 patients with stone pain. Further, the effectiveness lasted over 24 hours in 26 of the 49 responding to this agent. On one hand, improvement or disappearance of vesical urgency was recognized in 25 of 29 patients, and the effectiveness was observed shortly after injection in 16 and lasted over 24 hours in 13 cases. Toxicities of this drug were investigated in 54 patients with stone pain and 32 with urinary urgency. Side effects consisted of pain at the injection site in 4, a slight fall of blood pressure in 1, slight visual disturbance in 1, body heat sensation in 1, leukocytosis in 3 and elevation of alkaline phosphatase in 1. These symptoms were transient and disappeared without use of any agent. LM-001 is concluded to be a useful drug for controlling stone pain and vesical urgency since an immediate effect, long durability and high response rates were obtained without severe side

Adolescent↗
PubMed1989

[Pneumothorax, subcutaneous emphysema and mediastinal emphysema in transnasally intubated patients].

A 41-year-old woman was admitted to our clinic because of an acute subdural hematoma. After an emergency operation her neurological status improved with an increase in the Glasgow Coma Scale score from 6 to 11. On the second postoperative day she developed frequent episodes of clonic convulsive seizures localized in the face and the left upper extremity, and her level of consciousness deteriorated. Next day she was transnasally intubated for respiratory management, but no mechanical ventilation was required. While she was undergoing the CT scanning 5 days after intubation, respiratory arrest and cyanosis developed all of a sudden, and her face and neck became swollen. The chest x-ray revealed a marked subcutaneous emphysema, mediastinal emphysema and bilateral pneumothorax. CT at that time showed a diffuse low density area in the right hemisphere, and a marked midline shift returned. She did not regain consciousness and died 12 days after the incident. At autopsy an ulcer was observed in the wall of the trachea, where the tip or the cuff of the transnasal tracheal tube was supposed to be present. No perforation, however, was there. Case 2: A 75-year-old woman was admitted to our hospital because of SAH. In hospital course she was also transnasally intubated and required no mechanical ventilation. When she was undergoing the CT scanning 3 days after intubation, she developed subcutaneous and mediastinal emphysema similarly to case 1. Although it is reported to be not a rare complication in patients on a mechanical ventilator, subcutaneous emphysema or pneumothorax is extremely rare in those intubated patients with spontaneous respiration. The mechanism of these complications in these cases is briefly discussed.

Adult↗