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Biomedical subjects

M Martinelli

Publications and source records attributed to M Martinelli.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Critical analysis of the radioimmunological methods of determining creatine kinase isoenzyme MB (CK-MB), myoglobin (MG) and of LDH (H4) in ischemic cardiopathy].

We have studied 135 subjects of whom 100 were normal individuals; 10 with diagnosis of acute myocardial infarction (AMI); 10 with angina pectoris; 10 undergoing cardiac catheterism; 5 who underwent open heart surgery. To verify the radioimmunoassay usefulness of CPK cardiac isoenzyme (CK-RIA), of lactate dehydrogenase [LDH (H4)], of myoglobin (MG) in the diagnosis of ischemic disease, we have determined for serum samples: LDH (H4) by radioimmunoassay and HBDH by biochemical assay; CK by biochemical assay; CK-MB by biochemical and radioimmunological assay; MG by radioimmunoassay. The results indicate MG as a sensitive marker for the diagnosis of AMI. In fact serial serum determinations in patients with AMI showed myoglobin levels in 60% of the cases within 1 h after the onset of pain. The CK-RIA is the most sensitive test to evaluate infarct size and LDH (H4) conditioned by the amount of intracellular lactate is an useful test to evaluate myocardial anoxia.

Acute Disease↗
PubMed1978

[Value and limitations of scintigraphy in hematology].

The most important methods for carrying out scintigraphic investigation of the lympho-haemo-poietic system are described and their advantages and limitations reviewed with respect to pure methodology and to that of results interpretation. This field of radioisotopic symptomatology can still be considered a developing one; the techniques described have an indisputable diagnostic value, in spite of the advent of more sophisticated radiological techniques such as echography and computerized axial tomography.

Bone Marrow↗