Serum ornithine carbamoyltransferase (OCT) in rats poisoned with lanthanum, cerium and praseodymium. Acta Physiol. Pol., 1977, 28 (6): 589-594. The serum ornithine carbamoyltransferase in relation to doses of lanthanum, cerium and praseodymium, administered intravenously as chlorides, was investigated. A directly proportional relationship was found between the doses of these compounds and the serum enzyme level in rats. The lowest doses at which a rise in the serum OCT level occured were determined. They were: lanthanum - 0.75 mg/kg of body weight, cerium - 1.5 mg/kg, and praseodymium - 3 mh/kg. A decreasing toxicity of these elements with increasing value of atomic number was observed.

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The metabolism of 4-iodantipyrine--I125 (RIAP) in rat organism after intravenous injection.

Radioactive antipyrine labelled with I125 (RIAP) is used in radioisotope diagnostic methods for determination of the total water content of the organism, and cerebral and cardiac blood flow. The purpose of this study was to investigate RIAP metabolism in rats after intravenous administration. The distribution, excretion and passage with milk to the newborn animals were studied. Electrophoresis of the urine of the rats treated with this radioisotope was done as well. A rapid accumulation of the radioisotope in the thyroid was observed (the T 1/2 value was about 4 hours, and the greatest accumulation of RIAP was after 15 hours). The biological time of RIAP elimination from the thyroid was 5 days. I125 concentration in other organs was below 1% of the injected dose. Excretion was mainly with urine in three phases. In the urine of the rats two I125-containing fractions were found (a iodide fraction and an unidentified fraction). RIAP administration to lactating females caused passage of between 10 and 20% of the administered dose to pass to the newborns with milk. RIAP administration to pregnant rats raised this proportion by several per cent. Thyroid blockade with potassium iodide had no effect on RIAP passage with milk to the newborns. These results suggest a rapid loss of iodine from RIAP after intravenous injection.

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PubMedDate not supplied

Bivalent tin metabolism and toxicity after intravenous injection in rats.

With progressing advances in radioisotope diagnostic methods in nuclear medicine new radiopharmaceutic agents have been introduced containing inorganic soluble compounds of bivalent tin (Sn+2). An important problem is to study the metabolism and toxicological effects of Sn+2. In the presently reported work the distribution of Sn+2 was determined in the organism of rats at different time intervals after intravenous administration of 113SnCl2 (from 10 minutes to 4 months) and the rate of its elimination from the whole body was studied. Sn+2 toxicity was determined calculating the LD50/30 dose of Sn+2 and by means of the OCT test (ornithine-carbamyltransferase level in the serum). The investigation demonstrated selective accumulation of Sn+2 in the liver and spleen where it remained for a long time, phasic elimination of tin from the whole body, and its moderate toxicity after intravenous administration.

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Effect of various doses of cerium on the serum level of ornithine-carbamyltransferase in rats.

The relationships between different cerium doses administered intravenously as CeCl3 and the mortality of rats and their serum OCT level were studied. The LD50/30 value for cerium given intravenously to rats was 5.56 mg Ce/kg. A directly proportional correlation was demonstrated between intravenously administered Ce doses and the serum OCT level above a threshold dose.

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PubMedDate not supplied

Metabolism and toxicity of tetravalent tin after intravenous administration to rats.

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