[X trisomy with a rarely observed clinical syndrome].
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Biomedical subjects
Publications and source records attributed to M Marciniak.
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The distribution and retention of intravenously administered indium (113mInCl3) were determined in pregnant female rats. The highest accumulation of indium was found in the placenta during the last period of pregnancy. Five hours after administration the retention of indium in the placenta was about 38% of the administered dose. In the fetuses of these females the amount of radioactive indium did not exceed 1% of the injected dose. In the last period of pregnancy the placenta is the critical organ for intravenously administered administered indium (InCl3).
The causes of postoperative haematomas after operations for intracranial meningiomas are analysed. The percentage of this complication in this material was 5.2%. The most frequent concomitant disease in this series was arterial hypertension. The majority of postoperative haematomas was observed after longer lasting operations with totally excised large tumour. Perhaps, one of a large number of causes, is slight coagulopathy.
A variety of symptoms makes difficult the diagnosis and causes therapeutic problems after blunt limb trauma, particularly after long time from the immediate treatment. Three cases of sympathetic reflex dystrophy of the ulnar nerve as a late consequence of blunt upper limb traumas are presented. Long-term medical and surgical treatment produced temporary remission only. Full efficiency of the limb and remission were achieved only when anterior transposition of the nerve was done.
The aim of the study was qualitative and quantitative analysis of muscles and neuromuscular junctions of m. quadriceps, m. diaphragma and m. soleus in rats after being kept for 21 days under conditions of weightlessness. Degenerative changes were noted in both of these subjects and their intensity depended on the kind of fibres. The disorders were most pronounced in fibres and neuromuscular junctions of the soleus muscle in which red fibres prevail.
In earlier studies the toxicity of the lanthanides was determined on the basis of the LD50/30 value, increase of serum ornithine carbamoyltransferase activity, and the degree of passage of the lanthanides to the fetuses and milk. The purpose of the present work was to investigate the effects of toxic doses of lanthanum and cerium on the function of the placental barrier and the blood/organ barrier in mice using substances of known molecular weight labelled with radionuclides (14C-aminoisobutyric acid--AIB, 3H-thymidine and 125I-albumin). Increased uptake of 14C-AIB and 3H-thymidine was demonstrated in the liver, spleen and placenta of mice after toxic doses of La and Ce indicating disturbances in the function of the blood/organ barrier (liver, spleen, placenta) due to damage to the vascular endothelium or cell membranes. No disturbances were shown in the function of the placental barrier (which would have caused increased passage of these markers to the fetus), and rupture of the cell membranes in the studied tissues was not demonstrated (it would have caused increased passage of 125I-albumin, a macromolecular compound) in any of the studied organs in mice.
The authors analysed the data in 257 cases treated surgically for intracranial aneurysms. In 8 of these cases evidence of damage to the oculomotor nerve was found, as a result of aneurysms of the posterior communicating artery or the internal carotid near the site where the posterior communicating artery branches off. Six patients had oculomotor nerve paralysis and two had only partial involvement of the nerve. In 4 cases the aneurysm was not ruptured but manifested itself as headache followed by oculomotor damage. The authors stress the necessity of carrying out arteriography in each not clear case of oculomotor damage.