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Biomedical subjects

M Marchetti

Publications and source records attributed to M Marchetti.

At least 343 records · Page 19Linked to original sources

[Effects of the process of pharmaceutical deregulation on physicians].

By the term deregulation economists indicate the modulation of regulatory intervention resulting in a decrease of the limitation and restriction imposed on manufacturing and marketing activities. The process applies even to the pharmaceutical area and is enhanced by the increasing subjectivity of the consumers and the irreversible involvement of the medical profession with public expenditure. Health demand is no longer totally and exclusively fulfilled by physician's intervention and prescribing. Therefore, the resulting demedicalization and the use of means other than medications, such as surgical and medical aids, nutritional, dietetic and sanitary products and the so called medicated cosmetics, impose modifications of the preexisting regulation and organization. Generics will follow the assignment of a medicinal product to one class of medicaments rather than to another, thus allowing the adoption of substituting programs. Both national and European legislations follow this trend to attain economical advantages through pharmaceutical deregulation. The medical profession is changed by this process in a way which is much more significant than any other event.

Europe↗

Normal-phase liquid chromatographic determination of menadione in animal feeds.

A simple method is presented for determination of menadione in vitamin premixes and feedstuffs by normal-phase liquid chromatography (LC). Vitamin K3 is extracted and converted to free menadione, which can be determined directly by LC analysis. Peak area or height is measured at 251 nm, and menadione is quantitated by comparison with the working standard. Menadione can be estimated with a detection limit of 2.5 ppm. Recoveries for premixes ranged from 97.3 to 98.3% and for feedstuffs from 93.7 to 96.8%. The method allows the assay of all commercial K3 compounds in pure or stabilized form and is applicable to a wide variety of feeds and premixes.

Animal Feed↗

[Measuring venous pressure with the Doppler technic statistical data].

With reference to the measuring method suggested, we report the pressure indices noted in surgery, in order to compare them with those of non-surgical methods, using the Doppler. We also define some parameters for recording the measurements; failure to observe these might result in inaccuracy of the instrumental findings. We have to consider the index of maximum pressure to be attained using the pneumatic cuff, the lenght of time of compression, and the place at which the measurement is taken.

Female↗

Effects of dexamethasone on pro-inflammatory cytokine expression, cell growth and maturation during granulocytic differentiation of acute promyelocytic leukemia cells.

In basal conditions, NB4 and HL-60, two acute promyelocytic leukemia cell lines, express high levels of tumor necrosis factor (TNF-alpha) mRNA, whereas they do not synthesize appreciable amounts of the transcripts coding for interleukin-1 beta (IL-1 beta) or interleukin-8 (IL-8). Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types. These changes in mRNA levels were parallelled by the increased secretion of the two cytokines. Dexamethasone (DEX) had no effect on the induction of IL-1 beta mRNA, while it enhanced the G-CSF-, ATRA- and (ATRA+G-CSF) dependent secretion of the cytokine. In combination with ATRA and G-CSF, the corticosteroid increased the expression of leukocyte alkaline phosphatase, a late marker of granulocytic differentiation.

Alkaline Phosphatase↗

Beyond Bayes.

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Bayes Theorem↗