[The effect of age and drugs on the course of skin wound healing in humans (author's transl)].
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Biomedical subjects
Publications and source records attributed to M Mann.
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There is reported on experimental results (in people and animals) with regard to the course of the healing of wound. Factors influencing the healing of wound characterized by own results.
Healing of cutaneous wounds produced on the backs of young and old rats has been compared at ten various intervals between days 3 and 28. The only differences disclosed pertained to the exsudative and proliferative phases between days 3 and 5, which were found to develop more rapidly in young rats. The phase of the (predominantly afibrillar) connection of the wound stumps was reduced to less than 5 days. The exact nature of the "sticking" intercellular substance has not been clarified; most probably the substance represents nonfibrillar collagen. In the group of old rats neoformation of fibrillary neocollagen was somewhat more marked during days 7 to 9 than in yound rats, in whom a rather pronounced exsudative component was found during that period. No significant differences between the two groups were disclosed during the later stages of the experiment. Fibroblasts participated in collagen phagocytosis during the definitive reconstruction of the provisional, imperfectly oriented fibrillar connection of the wound edges.
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Histamine in doses of 25, 50, 100 and 200 mg/kg significantly inhibited mitotic activity of the stomach, duodenum and colon of rats. With the above doses this effect is not dose dependent. However, only the highest dose produced acute gastric mucosal ulceration. It is suggested that decreased mitotic activity is not causally related to ulcer provocation.
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Patients who undergo extensive resection of the pharynx along with laryngectomy usually are not able to develop esophageal speech. Since 1971 we have been working on a method for speech rehabilitation for these patients, which utilizes sound from a reed powered by tracheal air outflow. The sound is led into the pharynx via a fistula. Ten patients have been so managed, and six are now using this method of communication with satisfactory results. Preliminary studies on one patient indicated that his speech quality was judged to be superior to that produced by an excellent esophageal speaker. Efforts are continuing to study further the acoustical and perceptual properties of this form of speech and to improve further the method.
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