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Biomedical subjects

M Mann

Publications and source records attributed to M Mann.

At least 253 records · Page 14Linked to original sources
PubMed1980

[Replacement therapy with blood components in bone-marrow depression due to cytostatic drugs (author's transl)].

Intensive cytostatic treatment is associated with severe depression of bone-marrow function, which requires treatment with specific replacement of blood components. Erythrocyte concentrates should be given "pure", without leucocytes and platelets, to prevent rapid alloimmunisation. Different separation techniques (intermittent flow and continuous flow centrifugation, double-bag platelet pheresis) provide platelet concentrates containing 2.0 to 10.0 X 10(11) platelets from a single donor. Immunization against HLA and specific antigens can be minimised by careful donor selection. Effective granulocyte support in granulocytic patients requires large doses of granulocytes given daily to compensate the deficit.

Adolescent↗
PubMed1980

The radioactive bromide partition test in the diagnosis of tuberculous meningitis in children.

The radioactive 82Br partition test was performed on 83 children with suspected tuberculous meningitis. Three of 51 patients with a final diagnosis of TBM had a false negative serum to CSF bromide partition ratio of more than 1.6. Four of the 32 patients in whom TBM was excluded had a false positive ratio of less than 1.6; three of these had sever purulent bacterial meningitis. The test distinguishes TBM from viral meningitis. Antituberculous therapy does not affect the diagnostic value of the bromide partition test in the first few weeks of treatment of TBM.

Bromides↗
PubMed1980

Arthroscopy of the knee joint in the diagnosis and follow-up observation of osteochondritis dissecans.

Arthroscopy of the knee joint in patients with osteochondritis dissecans provides useful information that cannot be obtained by previously available examination techniques, both in the diagnostic work-up and in follow-up examinations. Thus, on the one hand, primary arthroscopy makes it possible to arrive at a relatively certain decision as to the therapeutic measures to be adopted, without the need for exploratory arthrotomy while, on the other hand, follow-up arthroscopy permits the effectiveness of the selected therapeutic measures to be examined. As a result, it becomes possible, at an early stage, to adopt other measures when revision of the therapy is required, even when the need for this has not yet become apparent either clinically or radiologically. Follow-up arthroscopy in the case of patients treated conservatively is indicated after 4 and 8 months, since in these cases, surgical procedures can be adopted where indicated. Our experience to date indicates that arthroscopic follow-up examination carried out 4 months postoperatively is too early. Only after about 8 months are visible changes of the cartilage that permit a prognosis with respect to the healing-in of the osteochondral fragment, can be expected. Further investigations should be carried out to determine whether, as some of our last arthroscopic examinations suggest, reparative processes in the region of chondromalacial changes can occur more than one year postoperatively.

Adolescent↗
PubMed1980

[Granulocyte and thrombocyte substitution].

The high rate of production makes it necessary to provide large amounts of platelets or granulocytes to support patients with bone marrow failure. With cell separators up to 10 X 10(11) platelets and more than 2 X 10(10) granulocytes can be withdrawn from a single donor. Therefore the selection of HLA-compatible donor-recipient pairs is possible. Platelets should be given in patients with hämorrhage and low platelet values due to decreased production. The substitution with granulocytes should be restricted to patients suffering from severe granulocytopenia (less than 500 granulocytes/microliter) and life threatening infection and when bone marrow recovery can be assumed.

ABO Blood-Group System↗
PubMed1979

Medical education.

Explore the source record for details and available documents.

Education, Medical↗
PubMed1979

Infantile jejunal mucosa in infection and malnutrition.

Sixteen children with refractory diarrhea and three malnourished children who had frequent episodes of acute gastroenteritis but little diarrhea at the time of hospital admission, were studied by peroral upper small intestinal biopsy. Six children were adequately nourished; five children weighed 62 to 79% of expected weight and eight weighed less than 60% of expected weight. Two of the malnourished children had giardiasis. Pathogenic bacteria were found in only one case. Varying degrees of mucosal atrophy with reduction of mean villous height were seen in 18 cases. The concentration of mononuclear inflammatory cells and plasma cells was about half that seen in well-nourished children with severe nongastrointestinal infections. The concentration of mononuclear cells in the lamina propria was about twice that seen in normal adults. The proportions of IgA-producing cells and cells that stained for secretory component were significantly reduced, as compared with normal adult control values. This reduction was most striking in children with malnutrition complicated by giardiasis. Enzyme histochemical studies were performed for leucine aminopeptidase, alkaline phosphatase and acid phosphatase. There was a tendency for considerably reduced acid phosphatase activity in all clinical groups (kwashiorkor, marasmic kwashiorkor and marasmus) of growth-retarded infants.

Child, Preschool↗
PubMed1978

Survey of graduates of a traditionally black college of medicine.

Over 700 Howard University medical alumni of seven representative classes graduating from 1955 to 1975 were surveyed by questionnaire in 1975-76. Replies of the 311 respondents confirm that this college of medicine has trained a substantial number of physicians who are providing care to blacks, the economically disadvantaged, and residents of inner city areas. Survey findings may also be useful in reaffirming the necessity for training more minority physicians, assessing the impact which the increasing number of minority physicians will have on health care delivery in this country, and suggesting the probable practice patterns of future minority graduates of U.S. medical schools.

Adult↗
PubMed1977

Influence of age and different drugs on the healing process in human skin wounds.

The paper contains the results the authors obtained when following, by means of electron-microscopic examination, the healing process of skin specimens after tetracyclin and hydrocortisone administration with regard to age. The results were compared to those in experiments, in which the healing of skin wounds in animals was judged by both mechanical tests and autoradiographic evaluations of the fibroblastic and epithelial reaction. It has been found that in the electron-optical picture age reduces the functional activity of the fibroblasts, delays contraction and permits the phase of exudation pass over to that of proliferation. After tetracyclin and hydrocortisone there were no structural changes in the fibroblasts; on the contrary, tetracyclin supported collagenization and both of them further suppressed exudation, which proved to be very favourable in the process of healing.

Adult↗
PubMed1977

[Medial-and simultaneous anterior-transfer of the tibial tuberosity (author's transl)].

Because of the triangular cross-section of the tibia medial transfer of the tuberosity according to Hauser and Roux leads to a backward displacement of the insertion of the patellar ligament accompained by rotation. This mechanically unfavourable effect can be made good by a change in technique of removing the tuberosity. It is not removed as a flat disk of bone but as a bone-block of triganular shape in cross-section and fixed on the medial surface of the tibia with a special flat-headed screw. The technique is described in detail.

Humans↗
PubMed1977

Effect of cyclophosphamide on the course of cutaneous wound healing.

The healing process of cutaneous wounds has been followed with the aid of mechanical tests, autoradiographic investigation of fibroblastic reaction in the wound and method of electron microscopy. Cyclophosphamide has been found not to have any substantial effect on the favorable course of healing of the surgical wound, hence, surgical intervention combined with postoperative administration of Cyclophosphamide does not jeopardize the healing process.

Animals↗