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Biomedical subjects

M Mancini

Publications and source records attributed to M Mancini.

At least 433 records · Page 24Linked to original sources
PubMed1977

Feedback regulation of metabolism by dietary constituents: lipids.

Cholesterol is distributed in different body pools, Input in these pools takes place through absorption of dietary cholesterol and endogenous synthesis. Absorption is limited in man. Endogenous synthesis is under negative feedback control, but its physiological relevance in man is less well established. Recent studies in familial hypercholesterolemia have shown a slower catabolism of low density lipoproteins (LDL) and an overproduction of apoprotein B. It seems that also the synthesis of the apoprotein B is controlled by a feedback mechanism. Overall concentration of lipids and lipoproteins in plasma is determined by the interaction between several genetic and dietary feedback mechanisms.

Animals↗
PubMed1975

Serum lipoprotein abnormalities in ischaemic heart disease.

Quantitative lipoprotein level data was obtained from healthy subjects and patients with ischaemic heart disease or peripheral vascular disease in four European communities. Hypertriglyceridaemia, due mainly to an increase in VLDL triglyceride, was commoner in London and Uppsala than in Naples and Geneva. In three communities there were significant increases in total serum cholesterol due to both increases in LDL and in VLDL cholesterol. Hypercholesterolaemic and hypertriglyceridaemic status were over-represented in both ischaemic heart disease and peripheral vascular disease patients.

Cholesterol↗