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Biomedical subjects

M M Ferguson

Publications and source records attributed to M M Ferguson.

At least 109 records · Page 6Linked to original sources
PubMed1985

Sex hormone involvement in the development of experimental virally induced murine salivary gland tumors.

Mice were given a single inoculation of polyoma virus at birth and then orchidectomised or oophorectomised. Unoperated groups received polyoma virus alone whilst further males received testosterone, and females received oestradiol thrice-weekly in addition to polyoma virus inoculation. All groups were then observed over the succeeding 370 days for the development of tumors of the submandibular and parotid salivary glands. Polyoma virus inoculation selectively induced salivary gland tumors in 70% of male animals and 30% of female animals given polyoma virus alone. Testosterone therapy increased the salivary tumor frequency from 69-90% whilst orchidectomy reduced the tumor frequency to 50%. Oophorectomy or oestrogen therapy did not significantly alter the salivary gland tumor frequency in females but oestrogen therapy did result in the development of second primary tumors of breast in 60% of female animals bearing salivary gland tumors. The role of androgens in the development of virally induced salivary gland tumors is discussed as are the possible mechanisms responsible for the development of second primary tumor of breast.

Animals↗
PubMed1985

Topical bleomycin in the treatment of oral leukoplakia: a pilot study.

Six patients with oral leukoplakia were treated by the daily application of a 0.5 per cent (w/v) solution of bleomycin sulphate in dimethyl sulphoxide. After 12 to 15 applications, the white patch peeled off and the resultant raw surface epithelialised over the following 14 days. Repeat biopsies showed a significant improvement in the histology, with reduced dysplasia and keratinisation.

Administration, Topical↗
PubMed1985

Oro-facial granulomatosis--a clinical and pathological analysis.

A study of 60 patients with oro-facial granulomatosis has been conducted and the clinical presentation of this disorder defined. It encompasses the previously recognised clinical entities of Melkersson-Rosenthal syndrome and cheilitis granulomatosa. The pathological features of the disease are lymphoedema and the presence of multiple non-caseating giant cell granulomata. These granulomata are histologically indistinguishable from those found in both gastrointestinal Crohn's disease and systemic sarcoidosis. Within this series of patients, nine had evidence suggestive of gastrointestinal Crohn's disease, and in six this was confirmed. A diagnosis of sarcoidosis was made in a further two patients. The relationship of oro-facial granulomatosis to these systemic granulomatous diseases is not yet clear. Patients with oro-facial granulomatosis who have gastrointestinal symptoms should be investigated for the presence of gastrointestinal Crohn's disease. Those without symptoms should be investigated for evidence of malabsorption or serological evidence of Crohn's disease. Within the present study, the erythrocyte sedimentation rate, full blood count, corrected whole blood folate, serum albumin and calcium were the most sensitive markers of gastrointestinal involvement. Sarcoidosis should be considered in all patients with oro-facial granulomatosis. The absence of clinical signs suggestive of sarcoidosis, a normal chest radiograph and normal levels of serum angiotensin-converting enzyme makes sarcoidosis unlikely.

Adolescent↗
PubMed1984

Peroxidase activity in relation to iodide, 17 beta-oestradiol and thioureylene drug uptake in human polymorphoneutrophils.

In polymorphoneutrophils (PMNs) phagocytosis is accompanied by an increase in peroxidase activity. Accumulation of iodide, thioureylene antithyroid drugs and 17 beta-oestradiol also occurs during the process. There is no evidence of an active iodide transport system in the PMNs as pertechnetate is not concentrated and neither ouabain nor perchlorate abolishes iodide accumulation. The uptakes of 125I, [35S]PTU and [3H]-17 beta-oestradiol were compared in phagocytosing PMNs and the effects of various compounds examined. In addition, chemiluminescence generation from luminol by PMNs and by horseradish peroxidase was studied. This indicated that uptake of all three compounds could be associated with activation of the peroxidase system, and inhibition of this enzyme system caused a reduction in their accumulation.

Estradiol↗
PubMed1984

The treatment of erosive lichen planus with a retinoid--etretinate.

The synthetic retinoid, etretinate, has been used to treat ten patients with erosive lichen planus of the oral mucosa. Beneficial effects were minimal, with only a slight decrease in the areas of ulceration being recorded after 8 weeks of therapy. Side effects were common and troublesome, however, outweighing the marginal improvement.

Adult↗
PubMed1984

The effect of cytotoxic therapy on saliva and oral flora.

Oral complications of cytotoxic therapy result from direct mucosal damage and, indirectly, occur as a consequence of immunosuppression. Such problems are further exacerbated as a result of associated xerostomia and secondary infection. Therefore, the aims of this study were to examine the salivary volume and composition (amylase, IgA, and lysozyme) together with the oral carriage of potential pathogens in patients receiving cytotoxic therapy. A pilot study comparing healthy controls with patients on chemotherapy for malignant conditions indicated that there were differences between the two groups. Therefore, a longitudinal study was initiated and twelve patients were assessed prior to and 4 and 12 weeks after the start of cytotoxic therapy. The 10-minute forced-spitting salivary volume and amylase and IgA levels all declined significantly over the 12-week period. Lysozyme content did not change. A quantitative increase in the oral carriage of Candida species, coliforms, and Staphylococcus aureus was also observed during therapy. Hence, it is concluded that cytotoxic chemotherapy results in a decreased salivary flow, a reduction in salivary amylase and IgA, and an increase in the oral carriage of opportunistic pathogens.

Adult↗
PubMed1984

Allergy to dental gold.

Allergy to gold dental appliances in very rare. This article reports the case of a patient who presented with acute oral ulceration following the placement of a gold crown. Biopsy of the ulcer and adjacent mucosa showed histologic features typical of a contact sensitivity. The patient subsequently had a positive patch test reaction to gold chloride. The literature is reviewed, and the dental implications are discussed.

Crowns↗
PubMed1984

The oral carriage of yeasts and coliforms in patients on cytotoxic therapy.

The oral carriage of yeasts and coliforms in a healthy adult population and a group of patients with malignancies, undergoing cytotoxic therapy was investigated. A quantitative increase in the intra-oral carriage of Candida species and coliforms was observed during cytotoxic therapy. The most frequent yeast and the coliform isolated were Candida albicans and Escherichia coli, respectively. Thus, the oral cavity may constitute a reservoir of potentially pathogenic flora in patients on cytotoxic therapy.

Adolescent↗
PubMed1984

Study of the ductal epithelial cell component of human labial salivary glands in vitro.

Salivary gland cultures were propagated from primary explant cultures of 55 human labial gland biopsies. Cultures were maintained for at least 7 days in 199 medium plus 20% newborn calf serum and growth measured at this time both by cell counting and planimetry of the area. Ductal cell population identification was undertaken on the basis of an intra-cellular function, the latter being the histochemical detection of the enzyme 11 beta-hydroxysteroid dehydrogenase. Epithelioid cell lines were derived by enzymatic and mechanical means. Non-invasive quantitation of the proportion of ductal epithelial cells present in primary explant cultures, and derived cell lines, was attempted using a radioimmunoassay to detect conversion in the media of cortisol to cortisone. The cell lines were terminated after undergoing 18 passages over 20 weeks. By this time the epithelioid morphology of cells could no longer be equated to a differentiated epithelial cell origin since conversion of cortisol to cortisone in the growth media no longer occurred.

11-beta-Hydroxysteroid Dehydrogenases↗
PubMed1983

Simultaneous computed tomography and sialography of the parotid and submandibular glands.

A technique of simultaneous computed tomography and sialography of the parotid and submandibular glands is described and the examination of 14 patients reported. Tumours were diagnosed in six cases and in the remaining eight cases inflammatory lesions were found. Sialographic enhancement offered definite advantages in localisation of lesions and examination of the tumour-normal tissue interface compared with either C.T. or sialography alone.

Humans↗
PubMed1983

Bilateral parotid gland aplasia.

Bilateral parotid gland aplasia is a cause of xerostomia. A case is presented in which the clinical diagnosis was confirmed with the use of 99mTcO-4 salivary gland scintiscanning and computerised tomography. The literature of this rare condition is reviewed and significance to the patient discussed.

Humans↗
PubMed1983

Salivary gland dysfunction following radioactive iodine therapy.

Radioactive iodine is used extensively for the treatment of thyrotoxicosis and thyroid carcinoma. Iodine is actively taken up by the salivary glands and, following its use, salivary dysfunction may result as a consequence of radiation damage. The literature is reviewed and a case is reported in which a patient presented with a significant increase in caries rate attributed to salivary dysfunction following radioactive iodine therapy for a thyroid carcinoma.

Adult↗