Biomedical subjects
Publications and source records attributed to M Luciak.
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The use of ethanol extract of propolis (EEP) on injured dental pulp results in the stimulation of regenerative processes. A reduction of disorders of the circulatory system is observed, inflammatory and degenerative processes are also reduced.
Mice were given i.v. injections of water solutions of ethanol extract of propolis (EEP) over a varying period of time. Some of the animals were sacrificed immediately following the last injection and some within 2--4 weeks after the last injections. Internal organ samples were taken and underwent a microscopic examination. Insignificant pathological changes in the liver were observed. These changes were transient and regressed within 2--4 weeks after the application of EEP.
The left ventricular systolic function was studied in 123 healthy men aged 23-24 years under the influence of exercise and during a two-hour restitution period. Left ventricular systolic time intervals (LVSTI) were evaluated by means of the Blumberger method with Holldack's modification before the exercise, immediately after its termination and after 30, 60 and 120 minutes. After exercise, a decrease was found in the absolute values of LVSTI and of the diastolic stage. During two-hour restitution, the authors found a decrease of left ventricular ejection time, total mechanical systolic time, total electromechanical systolic time, total ventricular electrical stimulation time and of the diastolic stage. A statistically highly significant decrease of all mentioned intervals was related to persisting, still after 2 hours, increased heart rate with which these intervals significantly correlated. The share (in percent) of LVSTI in the total cardiac cycle increased after exercise and was still increased after 2 hours following its termination. The relative increase of systolic time intervals was accompanied by a decrease in the duration of the diastolic stage.
Studies were carried out on 60 healthy men aged 20--24 years, divided into three groups. Group A (30 persons) performed work on bicycle ergometer in three phases: 420 +/- 90 kpm/min during 6 minutes, 840 +/- 180 kpm/min during 6 minutes and 1260 +/- 270 kpm/min during 6 minutes. Group B (20 persons) performed the same work after smoking 4 cigarettes. In group C (10 persons) the tests were carried out after they had smoked 4 cigarettes, without work load. In each group the serum FFA, TG and glucose levels were determined. It was found that just after the termination of physical exertion preceded by tobacco smoking (group B) FFA and TG concentrations decreased and glucose concentration increased more than in the control group (P less than 0.05, P less than 0.001 and P less than 0.001, respectively). During restitution, the FFA and TG concentrations were significantly lower (P less than 0.001) and the glucose level was higher (P less than 0.05) than in the group of non-smokers. After tobacco smoking, FFA concentration increased transiently in group C (P less than 0.001); the TG level did not change whereas the glucose level persistently increased (P less than 0.001). The results indicate the better utilization of FFA during physical exertion after previous tobacco smoking.
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The paper deals with the effect of thymic extracts from young foetal pigs and calves on the development of tumour xenografts, i.e. mouse ascites Ehrlich carcinoma and hamster malignant melanoma, in rats. The results of experiments showed that Ehrlich carcinoma developed in 4 out of 72 animals, i.e., in those animals which had received thymic extracts from young foetal pigs, Ehrlich carcinoma led to their death. Ehrlich carcinoma assumed a solid form and the cells changed in their shape. It developed normally, when retransplanted to mice. Hamster melanoma, when transplanted to rats given thymic extracts from young foetal calves, developed and survived for long periods of time (in one animal up to 190 days, and in the remaining animals much longer than in the controls and the animals injected with liver extracts from young foetal calves). The melanoma xenograft was not morphologically changed. A normal development of the malignant process occurred when melanoma was retransplanted to hamsters. Animals injected with thymic extracts from young foetal calves exhibited lymphopoenia and a fall in gamma globulin levels before tumour transplantation.
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