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Biomedical subjects

M Linden

Publications and source records attributed to M Linden.

At least 217 records · Page 12Linked to original sources
PubMed1982

Clinical trial of a test stick to control patient compliance under nomifensine treatment.

A reliable and rapid way of assessing patient compliance is the use of a semi-quantitative drug determination in the urine. Almost all urines were positive to a microchromatographic test stick 2-6 hours after 25 or 100 mg nomifensine was taken orally by healthy normal volunteers. The test reliability between different observers varied between 76 and 100 per cent. False positive results were regularly observed with carbamazepine and triamterene, and false negatives or weakened reactions with lithium. The test is reliable and highly 'time-specific'. Its applicability is, therefore, restricted to very specific questions.

Clinical Trials as Topic↗
PubMed1982

Diagnosis of endometrial carcinoma using the Mi-MarkR helix sampling technique.

The traditional Papanicolaou smear achieves only 20--60% diagnostic accuracy when applied to endometrial carcinoma. Consequently, various specially designed methods for the early detection of endometrial carcinoma have been tried out. The present study was a comparison of conventional curettage with a new technique, the Milan-Markley helix method (Mi-MarkR) for the obtaining of material from the uterine cavity for both cytological and histological evaluation. The material included 474 samples from 401 patients. The method is designed as an office procedure and is not intended to replace diagnostic curettage. It should be used as an additional diagnostic procedure in high-risk groups and in the follow-up of such patients. With cytological examination of the material the specificity was found to be 97.6% and the sensitivity 85.7%.

Adenocarcinoma↗
PubMed1981

Information and consent in schizophrenic patients in long-term treatment.

Eighty-five schizophrenic patients being seen on a regular basis in an outpatient clinic were interviewed about information given to them concerning their treatment. The patients were asked about risks and side effects on neuroleptics, coping strategies in regard to side effects, therapeutic effects and diagnosis, knowledge about therapy, and personal evaluation of their information. The results are discussed with respect to both the legal and therapeutic aspects of patients' information. Issues considered include the extent to which highly compliant patients know important facts about their treatment, how satisfied they are with the information given to them, and the implications for informed consent.

Adult↗
PubMed1981

Definition of compliance.

Several definitions of compliance are presented. These are Aspirational Compliance, Standard Compliance. Therapeutic Compliance, Attitudinal Compliance, Habitual Compliance and Therapist Compliance. The importance which the differentiation between these types of compliance holds for research and therapy is discussed.

Attitude↗
PubMed1980

Cytocidal effect of alpha-methylornithine, a competitive inhibitor of ornithine decarboxylase, on ehrlich ascites tumor cells in vivo.

The antiproliferative effect of alpha-methylornithine, an inhibitor of the initial and rate-limiting step in polyamine biosynthesis, was studied on Ehrlich ascites tumor cells grown in vivo. To assess drug-induced cell lethality, the loss of 125I from mice harboring 5-[125I] iodo-2'-deoxyuridine-labeled mouse tumor cells was determined during the course of alpha-methylornithine treatment. Mice that received the drug showed a significant increase in their rate of 125I excretion as compared to controls. This suggests that alpha-methylornithine kills an additional fraction of tumor cells beyond the fraction normally dying.

Animals↗
PubMed1980

Multiple sclerosis in American blacks.

In the period 1968 through 1977, multiple sclerosis (MS) was diagnosed in 349 patients at the Henry Ford Hospital. Of these 312 were accepted in the study and 53 were blacks. In this medical center where the overall population consists of approximately 50% blacks, the MS blacks comprised only 17% of the total MS population. White and black MS patients did not differ significantly for clinical characteristics of MS or for death rates. The MS black patients were divided in two groups, Northern- and Southern-born. The mean age of migration was 11.9 years. Southern-born blacks lived an average of 20 years in the North before the symptoms of MS began. Northern-born MS patients had a 5.5 earlier age of onset and the diagnosis was made 9 years sooner when compared with the Southern-born MS blacks. The Southern-born MS group more often showed a chronic progressive course wither initially or following a few exacerbations and remissions. These findings suggest that a possible genetic predisposition, as well as a geographically determined exposure to an environmental agent, may be related not only to the risk of developing MS, but in the American blacks may also influence the age of onset, the age of diagnosis, and even the clinical course of MS.

Adolescent↗
PubMed1979

[Models for the integration into therapy of work performed by helpers within the framework of psychiatric wards (author's transl)].

Several models for the integration of the work done by nurses and attendants into therapy are presented. In particular, the use of the "Scale for Behavioral Observation in Wards" is described. Important modes of behavior, which are relevant for therapy, can be trained for the benefit of nurses and attendants by observing the patients' behavioral patterns. The approach described in this article can improve the co-operation between the psychiatrist and nurses or helpers.

Hospital Units↗
PubMed1978

[The social partners of depressives].

The interactional behavior of depressed individuals and that of control subjects was observed by means of a coding system. The partners of depressed individuals showed different categorial frequencies than the partners of non-depressed individuals. In addition, differing categorial frequencies were displayed by long-term and short-term partners. Short-term partners of depressed individuals were reserved and considerate whereas long-term partners tended to display more demanding and critical behavior. The results are discussed in behavioral terms.

Adult↗