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Biomedical subjects

M Lewis

Publications and source records attributed to M Lewis.

At least 325 records · Page 18Linked to original sources
PubMed1989

A simulation model of forage yield, quality and intake and growth of growing cattle grazing cornstalks.

A simulation model was developed to predict corn crop residue yield and quality and intake and performance of growing cattle grazing cornstalks. The model is wholly deterministic and integrates the effects of weather, residue supply and animal components. Low temperatures increase animal energy requirements, whereas snow cover decreases residue available. Residual grain and leaf are calculated from grain yield. Residue quantity and quality are reduced daily by environmental losses and animal consumption. Daily performance is predicted based on the nutrients obtained from residue and supplemental feed. Under unlimited roughage supply, leaf, husk and grain are primary diet components. Grain consumption decreases as the supply diminishes and forage quality decreases with time. Intake is calculated based on digestibility and fecal output = .0365 W.75. Forage availability affects intake in a curvilinear fashion. Energy gain is predicted by NRC equations and protein gain from metabolizable protein supply. The model underestimated intake of calves measured with chromic oxide and in vitro DM disappearance. Simulated daily gain (y, kg) of calves grazing at several stocking rates was related to observed daily gain (x, kg) by the equation y = .012 + .853 x (R2 = .71, Sy.x = .077). The model overestimated response to protein supplementation. Severe cold weather was predicted to reduce gains or cause weight loss due to increased energy requirements for maintenance. The model can be used as an aid in both research planning and cattle management.

Animal Feed↗
PubMed1989

Phase I trial of mitomycin C immunoconjugates cocktails in human malignancies.

Nineteen patients with refractory solid malignancies received individualized combinations of mitomycin C conjugated murine monoclonal antibodies selected by immunohistochemical and flow cytometric screening of tumor specimens. There were no responses in this Phase I study. Thrombocytopenia precluded escalation above a mitomycin C dose of 60 mg per treatment cycle. Preclinical, clinical, and toxicity experiences with this investigational approach to the treatment of cancer are discussed.

Adult↗
PubMed1989

Multiple cycles of constant infusion recombinant interleukin-2 in adoptive cellular therapy of metastatic renal carcinoma.

Twenty patients were treated with metastatic renal cell cancer with 5-day cycles of constant infusion recombinant interleukin-2 (rIL-2) at 3 X 10(6) U/m2/day and with infusion of in vitro activated autologous mononuclear cells. The initial eight patients completed all rIL-2 and cellular therapy in a single 25-day treatment period. The subsequent 12 patients entered a 6-month treatment program involving two separate 15-day cycles of cellular therapy followed by four monthly cycles of maintenance rIL-2. Among eight patients in the 25-day treatment program, there were two with partial response (PR) and one with minor response (MR). None of these responses exceeded 2 months in duration. Among the 12 patients undergoing recycling of therapy, there were two with complete response (CR), two with PR, and one with MR. All four patients with CR or PR in this group demonstrated continuing response with recycling of treatment and none relapsed while receiving maintenance interleukin-2. Three remain in remission at 10, 11, and 12 months. These pilot data confirm that patients can tolerate multiple cycles of adoptive immunotherapy involving constant infusion rIL-2 and suggest that recycling of therapy is necessary to achieve clinically meaningful results.

Adult↗
PubMed1989

Self development and self-conscious emotions.

In each of 2 studies, the mirror-rouge technique was used to differentiate children into those who showed self-recognition and those who did not. In Study 1, 27 children (aged 9-24 months) were observed in 2 experimental situations thought to differentially elicit fear and embarrassment behaviors. In Study 2, 44 children (aged 22 months) were seen in the situations of Study 1 and 3 additional contexts thought to elicit embarrassment behavior. The results of both studies indicate that embarrassment but not wariness was related to self-recognition.

Emotions↗
PubMed1989

Leg ulcers: getting skin to grow.

A variety of leg ulcers (venous and advanced rheumatoid ulcers and those caused by arterial insufficiency, radiation, and diabetes) and their treatment are discussed in light of techniques applied in the physician's office.

Bandages↗
PubMed1989

Fibronectin fragments in lung lymph after thrombin-induced lung vascular injury.

Fibronectin is an adhesive glycoprotein found in plasma and lymph as well as between lung endothelial cells and their collagenous basement membranes. Fibronectin is highly sensitive to proteolytic cleavage. We determined if fragments of fibronectin appear in lung lymph in association with increased lung protein clearance after thrombin-induced intravascular coagulation. Thrombin was infused intravenously, (80 units/kg for 30 minutes) into sheep (n = 8) surgically prepared with chronic lung lymph fistulas. Plasma and lymph fibronectin was assayed by electroimmunoassay. Fibronectin fragments were detected using Western blot analysis. After thrombin infusion, lymph flow increased 650% above baseline within 1-2 hours in association with a 35% decline in lymph-to-plasma total protein concentration ratio. This was followed by a second phase (3.5-6 hours) of normalized lymph-to-plasma ratios coupled with sustained elevation of lymph flow. Lung protein clearance remained elevated (p less than 0.10) for 5.5 hours. Plasma fibronectin levels declined slightly over 1-5 hours (zero time = 597 +/- 64 micrograms/ml; 1.5 hours = 478 +/- 59 micrograms/ml) and then increased significantly (p less than 0.05) over 24-48 hours (760 +/- 85 micrograms/ml). The amount of low molecular weight fibronectin fragments in lung lymph increased over the 1.5-6 hours post-thrombin and then declined over 12-48 hours. Thus after thrombin infusion, fragments of fibronectin were usually detected in increased amounts of lung lymph in association with an elevation of lung protein clearance.

Animals↗
PubMed1989

Cognitive and motor differences among low birth weight infants: impact of intraventricular hemorrhage, medical risk, and social class.

The independent impacts of severe intraventricular hemorrhage, other common medical complications of prematurity, and socioeconomic status on the development in the second year of life of 32 low birth weight subjects were explored. Outcome measures included standard tests of mental and motor development, an evaluation of language competence, and an assessment of information processing ability in a habituation/recovery paradigm. Partial correlations indicated that intraventricular hemorrhage influences cognitive and motor development independently of the other predictor variables. Socioeconomic status predicted language ability and recovery of attention to a novel stimulus independent of the other predictors. Medical complications other than intraventricular hemorrhage also made an independent contribution to the variance in language outcome. Implications of these findings are discussed.

Attention↗
PubMed1988

Phosphohistidine is found in basic nuclear proteins of Physarum polycephalum.

Nuclear extracts of the true slime mold, Physarum polycephalum, show protein histidine kinase activity towards exogenous histones [(1985) J. Biol. Chem. 260, 16106-16113]. Physarum microplasmodia were labeled with [32P]phosphate in vivo and two basic proteins containing alkali-stable phosphate were detected. The labeled proteins comigrated with Physarum histones H1 (approximately) and H2A and phosphoamino acid analysis showed that each protein contained [32P]-phosphohistidine. The H2A-like protein was also labeled in isolated nuclei incubated with [35S]thio-ATP. We conclude that some Physarum nuclear proteins contain phosphohistidine.

Histidine↗
PubMed1988

Principles of biotherapy and its application to the treatment of disseminated renal cancer.

Monoclonal antibody technology permits the preparation of tumor-specific immunoglobulin reagents that can be used directly in tumor therapy or that can be coupled to various chemotherapeutic drugs or toxins to aid in their delivery to the tumor site and thus enhance their therapeutic effectiveness. Additionally, recombinant DNA technology has facilitated the economic production of rare lymphokines (e.g., interleukin 2, interferon alpha and interferon gamma) or cytokines (tumor necrosis factor, lymphotoxin) that can either modulate the host immune response or kill tumor cells, respectively. These developments collectively have led to the development of a fourth modality for treatment of human cancers--biotherapy--as an addition to surgery, radiation, and chemotherapy modalities. This paper presents the rationale and emerging practice of the biotherapy of cancer and documents early clinical results, including the treatment of metastatic renal carcinoma at the Biological Therapy Institute.

Animals↗
PubMed1988

Analysis for linkage between F13A and three chromosome 6 marker loci: evidence for 6pter:F13A:HLA:GLO1:cen gene order.

The results of the present study provide independent support for F13A:HLA linkage and refine the F13A:HLA and F13A:GLO1 linkage relationships. Analysis of the corresponding recombination fractions for the total paternal F13A:HLA and F13A:GLO1 peak lod scores (z) indicates a locus order of 6pter:F13A:HLA:GLO1:cen. Lod scores between F13A and PLG, a locus recently assigned to chromosome 6, exclude close linkage between these loci.

Child↗
PubMed1988

Morbidity and mortality of myocardial infarction in the MONICA study area Augsburg in 1985.

In the year 1985, 998 (734 men, 264 women) cases of acute coronary events were registered among the 25-74 year-old residents of the study area (151,489 men and 171,093 women) of whom 583 (403 men, 180 women) died within 28 days (case fatality). Both AMI as a clinical diagnosis and AMI as a cause of death are validated by defined MONICA diagnostic criteria (acute symptoms, enzyme level, ECG, autopsy diagnosis). The AMI-risk (MONICA diagnostic categories 1, 2, 3, 9) in the study area Augsburg is relatively low (incidence: men 302, women 113; attack rate: men 444, women 138; death rate: men 241, women 92; all per 100,000 for each group). The 28-day case fatality is comparatively high (men 54%, women 67%). A comparison of the Augsburg rates with those of three other centers shows that the Augsburg figures are in the lower range.

Adult↗