Search PubMed⌕ Search

Biomedical subjects

M Leroy

Publications and source records attributed to M Leroy.

At least 91 records · Page 5Linked to original sources

[Diaphragmatic eventration in adults. Apropos of 20 cases].

Twenty adults with a mean age of 49 were operated on between 1972 and 1980 for eventration of the diaphragm. The etiology was probably traumatic in 11 cases; it was congenital in 2 and degenerative in 7. The functional signs were usually respiratory (55%) or digestive (10%). In all cases, the diagnosis was based on standard fluoroscopy showing superelevation of the hemidiaphragm, which was visualized fluoroscopically as immobile while a pneumoperitoneum showed a absense of any tear. Spirography confirmed a restrictive deficit which was sited broncho-spirometrically on the eventration side. Surgical repair was achieved in most cases by thoracotomy (19 cases) and consisted in plication (17 cases) or incision followed by suturing of the overlapping edges of the muscle (3 cases). Postoperative complications included the death of the patient with multiple trauma, on the eight postoperative day, as a result of the cerebrovascular accident, and in another case rutpure of the repair on the second day, requiring a second operation. Apart from one patient who died as a result of a fatal accident two years postoperatively, all the surgically treated cases are alive, and, with one exception, symptom free. After an average follow up period of 2 years and 2 months, the control respiratory function tests show a 21% improvement in vital capacity and a 20% increase in FEV1. On the basis of these results, the authors conclude that this functional surgery is justified in the case of patients presenting with typical clinical symptoms, and worth considering in cases where respiratory function tests show a restrictive deficit, but also in patients who do not complain of breathlessness.

Adult↗

The beta-blocking effect of diacetolol in humans and its relationship to plasma levels.

The beta-blocking action of diacetolol was studied in six healthy subjects after oral administration of placebo, 200, 400, and 600 mg diacetol in random order by means of exercise tests. Diacetolol plasma levels were determined by the HPLC method. Drug administration had No significant influence on resting heart rate and resting systolic or diastolic blood pressure. The beta-adrenoreceptor blockade was expressed as percentage reduction of exercise heart rate (delta FC%). This value increased with the size of the dose. There was a linear relationship between delta FC% and log plasma levels of diacetolol for each subject, except one. Analysis of variance did not provide a common regression line for all subjects.

Acebutolol↗

[Indications and results of the use of YAG laser in bronchology. Apropos of 89 cases].

A YAG Laser beam adapted to bronchial endoscopy was used in 89 patients (6 bronchial tumors, 7 tumors of reduced malignancy, 37 tracheo-bronchial cancers, 39 iatrogenic lesions including 24 stenosis and 15 granulomas). Curative indications (isolated bronchial tumors, diaphragm-like stenosis) were rare. The authors stress the interest of palliative indications: inoperable tracheal stenosis and certain forms of tracheobronchial cancers. The criteria of lesions attainable by the Laser are specified.

Bronchial Diseases↗

[Relapsing polychondritis with predominant respiratory involvement treated with Dapsone :value of pulmonary function tests (author's transl)].

A 31-year-old patient had developed lesions in the nasal cartilage during infancy, followed by laryngotracheal lesions when 9 years old. The latter lesions recurred when he was 21, followed several years later by an affection of the main left bronchus and the diagnosis of relapsing polychondritis. Initial respiratory function tests showed mainly a reduction in maximum inspiratory flow, due to sequelae in the upper respiratory tract. Repeated tests were able to demonstrate lesions in the main left bronchus, determining severe expiratory slowing. No significant improvement occurred after one year of corticoïd therapy. Treatment with sulfones (Disulone) produced clinical improvement (reappearance of a vesicular murmur in the left lung) and a twofold increase in FEV1. Functional improvement was even better demonstrated by successive flow-volume curves.

Adult↗

Accidental acute mercury vapor poisoning.

Accidental acute mercury vapor poisoning in three persons is reported. Three hours after exposure, symptomatology began by chills, vomiting, diarrhea and chest pain. Two patients, respectively 67 and 77 year old, presented severe pulmonary edema, then neurological symptoms with tremor and coma. This toxic pulmonary edema, which entailed artificial ventilation, was followed in both cases by an acute interstitial pulmonary fibrosis which led to death respectively after six and sixteen days. In the third case (a thirty eight year old patient) a skin rash, erythematous and pustuliform was observed. Analysis for total mercury by flameless atomic absorption showed very high mercury levels in blood and urine of the three patients. The effect of treatment by Dimercaptopropanol on renal excretion of mercury was studied. Optic and electron microscopy of the lung of the two patients who died showed the pulmonary changes of acute interstitial fibrosis.

Adult↗

[Studies on the viability of pathogenic amebae of the genus Naegleria in water of different sources (author's transl)].

Water specimens taken from the public water supply (A), a swimming-pool (B), and an inland lake (C) were infected with pathogenic amebae of the genus Naegleria (strain TY/Richmond). The specimens were stored at various temperatures for different periods. The water was then filtered and examined for naegleriae by animal inoculation. The results summarized in table 1 indicate that pathogenic naegleriae are viable at least for some weeks in warm tap and natural waters. Water from indoor swimming-pools however, may be a less suitable medium for the viability of pathogenic naegleriae.

Amoeba↗

[Effect of catecholamines in blood flow in arteries of distribution].

In large arteries, distributing blood to an area (hind leg of dog), the vasomotor substances (catecholamines) induce differences in flow. In case of state of vasoconstriction, the mean velocity of flow decreases, while the amplitude of pulsatile flow and the pressure increase. The radial expansion is wider. In case of state of dilatation, inverse reactions are observed.

Animals↗

[Effect of localized heat on blood flow in arteries of distribution].

In large arteries distributing blood to an area (hind leg of dog), local heat induces a vasodilatation. The mechanical reactions (variations of mean velocity of flow and amplitude of pulsatile flow) express a distal dilatation. Radial expansion responds in original way (pulsation become uniform).

Animals↗

[Not Available].

Explore the source record for details and available documents.

Greece, Ancient↗

Effects of diabetes and insulin treatment of diabetic rats on hyaluronan and hyaluronectin production in injured aorta.

The present study was conducted to determine the effect of diabetes with and without insulin treatment on the production of hyaluronen (HA) and distribution of hyaluronectin (HN) in the rat aorta 14 days after injury with a catheter balloon. Injury increased intima-media wet weight (+11%) and DNA content (+37.5%). This increase was slightly enhanced in untreated diabetic rats (+14.7% for wet weight and +48.9% for DNA content) and was significantly greater in diabetic rats treated with insulin (+28.9% for wet weight and +54% for DNA content). HA content increase in the injured aorta of nondiabetic rats (+43.6%) was similar in untreated diabetic (+44.7%) and more pronounced in diabetic rats treated with insulin (+91.3%). HA was markedly expressed in the neointima of nondiabetic rats, particularly near the lumen of the aorta. In untreated diabetic rats, HA was present throughout the neointima and not mainly close to the lumen. HA staining in the neointima of diabetic rats treated with insulin was similar to that in nondiabetic rats. HN was strongly expressed throughout the neointima of all groups. Injury enhanced the production of a high molecular mass HN (>400 kDa); this was not observed either in untreated or in insulin-treated diabetic rats. In conclusion, insulin treatment promoted the proliferative response of aorta to injury and this was associated mainly with increased HA production. This finding suggests that HA, which has been shown to play a crucial role in smooth muscle cell proliferation and migration, may be involved in the promoting effect of insulin treatment on arterial wall reaction to injury.

Animals↗

[Changes in the spirography of paraplegics related to different postures in the air and water].

Respiratory insufficiencies in subjects with spinal cord injury were studied in five situations: in the air (sitting, dorsal supine position, declivous--15 degrees), and immersed in water up to the neck (sitting, dorsal supine position). Results were compared to those for a group of normal subjects. Total lung capacity (TLC), residual volume (RV), functional residual capacity (FRC), vital capacity (VC), forced expiratory volume per second (FEV1) and peak expiratory flow (PEF) were measured and their ratios with theoretical values of each subject were calculated. In handicapped subjects, FEV1 is less significantly diminished than VC and PEF. TLC does not vary, FRC is higher only sitting in the air, RV is more increased. Between situations, FEV1 never varies. In normal subjects, RV does not vary but, sitting in the air, TLC, VC, FRC and PEF increase. In handicapped subjects sitting in the air, VC decreases, RV and FRC increase, TLC and PEF do not vary. In normal and handicapped subjects, the other situations are comparable all together.

Adolescent↗