[Cases of infectious endocarditis associated with mitral valve prolapse syndrome].
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Biomedical subjects
Publications and source records attributed to M Lengyel.
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Echocardiographic examination revealed intracardiac calcification in 20 out of 70 chronically dialysed patients. The process appeared more frequently in those suffering from severe renal osteodystrophy. It was often associated with rhythm disorder. Parathyroid hyperfunction is rated as one cause of intracardiac calcification.
Exercise performance in 41 men with impaired left ventricular function following an acute myocardial infarction was studied. Twenty (intervention group) subsequently underwent a 4-month supervised exercise training programme in an outpatient capacity, with three sessions per week. On completion, exercise performance was compared to the 21 control patients who received conventional rehabilitation. Initial tests showed no difference between the two groups. At the end of the programme significant improvement was found in all the investigated parameters in the intervention group. Supervised training had a beneficial effect on the physical working capacity of the patients with left ventricular dysfunction and no complications arose.
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In this pilot study of 50 consecutive patients with prior myocardial infarction, the results of two-dimensional echocardiographic and angiographic analysis of wall motion abnormalities were correlated, and their prognostic significance was determined. There was overall good agreement (88%) between the two methods. In general, the greater the left ventricular dysfunction, the worse was the prognosis. The 3-year survival was significantly reduced for patients with a left ventricular wall motion score index of 2.5 or greater (P = 0.024). These findings were essentially similar to the reduced survival rate associated with decreased angiographic ejection fractions (less than 40%). This study suggests that two-dimensional echocardiography, a noninvasive and relatively inexpensive technique, can provide prognostic information in patients with prior myocardial infarction.
Two methods of measuring right ventricular cardiac output with pulsed Doppler two-dimensional echocardiography were developed in 29 patients who underwent cardiac catheterization and angiography. Using tricuspid inflow and main pulmonary artery outflow methods we determined cardiac output, and good correlations were observed between thermodilution and Doppler measurements (r = 0.93 and 0.89, respectively). Results by the two methods correlated closely in patients without regurgitant lesions. In patients with tricuspid regurgitation, right ventricular inflow was always greater than right ventricular outflow volume while the reverse was true in those with pulmonary insufficiency. Furthermore, we investigated the right ventricular peak filling rate as the Doppler peak diastolic velocity X cross-sectional area of the tricuspid annulus and half filling right ventricular fraction derived from the time velocity integral of the Doppler-determined velocity curve. For the tricuspid valve morphologically, the Doppler-derived velocity profile in diastole resembled the first derivative of the angiographic right ventricular volume curve. A significant correlation was observed between the Doppler echocardiographic and angiographic peak filling rate (r = 0.84). The results of the present study validate the use of Doppler two-dimensional quantitative measurements of the right ventricular output, regurgitant fraction and indexes of diastolic function.
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Echocardiography has revolutionized the practice of cardiovascular imaging. A complete one- and two-dimensional echocardiographic examination can provide non-invasive information about cardiac anatomy and function. Pulsed wave (PW) Doppler technique has permitted to appreciate normal and abnormal blood flow patterns. Abnormal blood turbulence associated with stenosis, regurgitation and cardiac shunts has been characterized. However, only with the recent advent of continuous wave (CW) Doppler technique has the noninvasive ultrasound examination been able to accurately estimate intracardiac blood flow velocities which can be used to determine gradient, pressure and flow. Now, in a complete ultrasound laboratory, one can non-invasively determine many of the cardiac functional and hemodynamic parameters which heretofore were relegated to invasive cardiac catheterization.
Two cases of successful surgical removal of left ventricular thrombi are presented. Two-dimensional echocardiography revealed in the first case multiple masses of thrombi in the dilated ventricle consistent with congestive cardiomyopathy and emergency surgery was performed for cerebral embolism. In the second case the thrombus was pedunculated and calcified, a probable sequel of a 17-year old myocardial infarction. The pertinent literature of echocardiographic and surgical aspects of left ventricular thrombi is reviewed.
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Surgical treatment in 8 cases of non-tropical eosinophilic endomyocardial diseases with (4 patients) and without (4 patients) eosinophilia is reported. Follow-up results (1 to 4 years) in the 6 survivors, including hemodynamic re-study, were excellent even in patients operated on in the thrombotic stage (3) or with hypereosinophilia (2), or with dominant right ventricular involvement (3). Two-dimensional echocardiography gave the correct description of the pathologic stage and ventricular involvement in 6 of the 8 cases before catheterization.
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Eleven patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with congestive cardiomyopathy (COCM) were studied to determine the usefulness of mean normalized velocity of circumferential fiber shortening (VCFS), mean normalized velocity of circumferential fiber lengthening (VCFL) and left ventricular diastolic distensibility obtained noninvasively from combined recordings of simultaneously calibrated left apex cardiogram and M-mode echogram. Twenty-two normal subjects were similarly investigated and served as a control. In HOCM VCFS were increased (1.83 +/- 0.2 s-1 versus 1.22 +/- 0.1 s-1 for controls, p less than 0.02) and both VCFL and diastolic distensibility were decreased (VCFL: 0.50 +/- 0.1 s-1 versus 1.32 s-1 in controls, p less than 0.001; diastolic distensibility: 0.03 +/- 0.004 cm/mmHg-1 compared with 0.18 +/- 0.003 cm/mmHg-1 for controls, p less than 0.001). In COCM all investigated indexes were diminished (VCFS: 0.49 +/- 0.1 s-1 versus 1.22 +/- 0.1 s-1 for controls, p less than 0.001; VCFL: 0.70 +/- 0.1 s-1 versus 1.32 +/- 0.1 s-1 in controls, p less than 0.01 and diastolic distensibility: 0.05 +/- 0.003 cm/mmHg-1 compared with 0.18 +/- 0.003 cm/mmHg-1 for controls, p less than 0.01). The echo-apexcardiographic indexes were significantly correlated with many analogous invasive indexes. It is concluded that the value of both M-mode echocardiography and calibrated apex cardiography is enchanced by a combination of the two methods which opens the possibility of a fresh approach to the noninvasive study of cardiac performance in cardiomyopathy.
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Statistically significant correlations were demonstrable between the incidence of bone abnormalities due to parathyroid hyperfunction and of pericarditis in 130 patients maintained on chronic haemodialysis. Parathyroid hormone is regarded on these grounds as one of the possible factors accounting for the production of non-infective uraemic pericarditis.