Search PubMed⌕ Search

Biomedical subjects

M Lee

Publications and source records attributed to M Lee.

At least 1,081 records · Page 60Linked to original sources
PubMed1980

Effect of litter size on the physical growth and maturation of the offspring of rats given alcohol during gestation.

A study was conducted to determine if retarded postnatal growth and maturation of the offspring of rats receiving alcohol prior to and during gestation could be corrected by adjusting litter size at birth to 3 pups. Female Sprague-Dawley rats (200 to 220 g) were divided into 3 dietary treatment groups. Group 1 (alcohol) was fed ad libitum a stock diet (Purina Rat Chow) plus 20% alcohol in drinking water for at least 4 weeks before mating and 30% alcohol throughout gestation. Group 2 was pair-fed the stock diet and corn starch calorically equivalent to the amount of alcohol consumed. Group 3 (control) received the stock diet and water ad libitum. In each group litters were reduced to 3 or 8 pups on the first day of birth. After birth all animals had free access to water and stock diet until day 51 post conception. In agreement with previously reported studies, the offspring of alcohol-fed rats were lighter in body weight and smaller in body and tail length at all ages than were the controls. However, animals maintained in litters of 3 were not significantly different in weight and length from those raised in litters of 8, either for alcohol group or the controls. The pair-fed litters were not significantly different from the ad libitum controls. Skeletal measurements and calf muscle widths of alcohol fed rats at day 51 post conception were significantly less than those of ad libitum controls of the same litter size, with the pair-fed animals lying somewhere in between. However, in no case did alcohol or control animals raised in litters of 3 differ from the same group maintained in litters of eight. Total bone maturity scores of alcohol-fed offspring were significantly retarded, relative to pair-fed and ad libitum controls, but within any group, litters of 3 did not differ from litters of eight. The results of this study indicate that retarded postnatal growth and maturation of the offspring of rats receiving alcohol prior to and during gestation represents a direct effect of alcohol and is not a consequence of underfeeding.

Animal Nutritional Physiological Phenomena↗
PubMed1980

Weight gain of rats fed medium-chain triglycerides is less than rats fed long-chain triglycerides.

Weight gain was measured in rats fed test diets with two types of fat: corn oil and medium-chain triglycerides (MCT). These diets were selected because fatty acids from corn oil enter the circulation as chylomicrons through the lacteals. Fatty acids from medium-chain triglycerides reach the liver directly through the portal circulation. Weight gain was normal when the diet contained MCT, but was increased with the higher percentage of corn oil in the diet. Caloric intake was lowered, but its conversion to fat was higher on the high-fat diets. Serum triglycerides, but not glucose, were higher in both male and female rats fed the MCT compared to the corn-oil diet. These experiments suggest that the route by which nutrients are absorbed plays a role in regulating body-fat storage.

Absorption↗
PubMed1979

A low frequency mosaicism for monosomy 21 in a live born female.

Monosomy 21, whether homogeneous or as a mosaicism, is very uncommon. We report here a 3-month-old white female with a low degree of monosomy 21 in the blood karyotype (6.5%, 110 cells counted) but not in the skin fibroblasts, which contained only the normal chromosome complement. The patient's physical features included microcephaly with frontal slanting; prominent occiput; ridge-shaped sutures; agenesis of the corpus callosum; large, prominent ears; high and narrow palate; micrognathia; tetralogy of Fallot; crowded toes; and dry, thick skin with very little subcutaneous tissue. The case is discussed in light of the suggested clinical features of the "monosomy 21" syndrome and the possible implications of such a low-grade mosaicism in prenatal diagnosis.

Abnormalities, Multiple↗
PubMed1979

The effect of protein-energy malnutrition on appositional bone growth in the rat.

During protein-energy malnutrition appositional bone growth in the seventh caudal vertebra of the rat slows and finally ceases. During rehabilitation appositional growth begins agains and attains a rate in excess of that of the controls. This may account for alterations in skeletal proportions resulting from malnutrition.

Animals↗
PubMed1979

The role of C. albicans in denture stomatitis.

Denture stomatitis is an erythematous disorder of the denture-bearing tissues, especially the maxillary hard palate. Frequently it mimics many oral lesions. Early diagnosis of the lesion is essential to assure rational therapy. A diagnostic procedure based upon the enumeration of Candida albicans appeared to be feasible. A control group of twenty fully dentate subjects with no clinical evidence of stomatitis was sampled to establish normal concentrations of C. albicans in the oral flora. Samples were taken from a triangular area of the hard palate, serially diluted in broth, and all dilutions were incubated aerobically. In the control population, C. albicans never exceeded 100 organisms per square centimeter per subject sample. A population of edentulous patients with denture stomatitis, prior to any therapy, was similarly sampled. In many of these patients the concentration of C. albicans always exceeded 10,000 organisms per square centimeter per patient. The patients received denture replacements and antimycotic antibiotic therapy. Follow-up cultures were taken 4 to 6 weeks after completion of therapy. All patients were found to be free of denture stomatitis.

Antifungal Agents↗
PubMed1979

Objective assessment of accommodation orthoptics. I. Dynamic insufficiency.

Three young adult females with symptoms related to focusing difficulties at near were treated by standard orthoptic procedures, including jump focus, plus-and-minus lens flippers, and pencil pushups. Home training was done 20 minutes each day for 4 1/2--7 weeks. Objective measures of dynamic accommodation were made each week in our Neuro-optometry Clinic. Initially, these objective measures showed prolongations of time constants and latencies of accommodation. During treatment, the patients showed significant reductions in time constants and latencies that correlated well with elimination of subjective symptoms. Also, in all three patients, flipper rates increased and symptoms were either markedly diminished or no longer present at termination of therapy. These results clearly demonstrate that orthoptic treatment in our three adult patients resulted in objective improvement of accommodation function.

Accommodation, Ocular↗