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Biomedical subjects

M Laus

Publications and source records attributed to M Laus.

At least 37 records · Page 2Linked to original sources
PubMed1983

Multiple non-ossifying fibromata with extraskeletal anomalies: a new syndrome?

Ten patients with multiple non-ossifying fibromata are reported. All had associated extraskeletal congenital anomalies such as café-au-lait spots, mental retardation, hypogonadism or cryptorchidism, ocular anomalies or cardiovascular malformations. The radiographic picture and the distribution of the skeletal lesions are characteristic and constant. There are lucent areas in the shaft with a sclerotic margin; these areas narrow the medullary canal or may completely fill it. It is suggested that these features characterise a new malformation syndrome, possibly allied to neurofibromatosis. After skeletal maturation is complete, the skeletal lesions may (like non-ossifying fibromata) regress and undergo spontaneous healing.

Abnormalities, Multiple↗
PubMed1982

Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities.

This review of 27 cases serves to emphasis that periosteal chondrosarcoma and periosteal osteosarcoma are two distinct entities. Clinically, periosteal chondrosarcoma is less painful than periosteal osteosarcoma and runs a slower course. Radiographically, periosteal chondrosarcoma tends to affect the metaphysis and contains granular or "popcorn" opacities; while periosteal osteosarcoma more often affects the mid-diaphysis and shows lytic lesions with some spicules of reactive bone perpendicular to the underlying cortex. Histologically, periosteal chondrosarcoma shows lobular well-differentiated cartilage with Grade I or II (rarely Grade III) malignancy; periosteal osteosarcoma has a chondroid matrix with some osteoid component and Grade II or III malignancy. The prognosis in periosteal chondrosarcoma is good; conservative surgery is usually effective and metastases are very uncommon. In periosteal osteosarcoma the prognosis is less satisfactory but is better than that of other osteosarcomata; wide surgical excision is, however, needed and the incidence of metastases is about 15 per cent.

Adolescent↗
PubMed1982

Surgical treatment of isthmic spondylolisthesis in adults. Review of 44 cases with long-term control.

The results are presented of 44 cases of isthmic spondylolisthesis in adults treated surgically. The Authors consider three groups treated by: A) surgery to free the nerve roots, B) posterior fusion with or without freeing of the nerve roots, C) posteriorlateral fusion. After an analysis of the techniques at present in use for the treatment of spondylolisthesis, the Authors conclude that, in adults, posteriorlateral fusion produces a high percentage of successes with low risk.

Adult↗
PubMed1982

Synovial chondromatosis and chondrosarcoma of the hip: indications for surgical treatment.

Five cases of cartilaginous neoproliferation of the hip, of synovial origin, were treated by different surgical techniques. From the clinical point of view these cases can be classified as simple synovial chondromatosis and progressive synovial chondromatosis. The writers, on the basis of their own experience and on data collected from the literature, conclude that simple synovial chondromatosis should be treated by partial or total synovectomy, while progressive synovial chondromatosis should be treated by total synovectomy with or without arthroplasty with total hip prosthesis. Synovial chondrosarcoma should be considered a neoplasm with at least local malignancy and should be treated by wide surgery.

Adult↗
PubMed1982

Complementary immunotherapy in the treatment of chronic osteomyelitis.

The authors present a retrospective study of 492 cases of chronic osteomyelitis treated with active immunotherapy to complement surgical and antibiotic treatment. The systematic application of this treatment, which is based on the use of antistaphylococcal vaccines and/or auto-vaccines resulted in the osteomyelitic process being cured in 80 per cent of cases, with complete closure of the fistulae maintained for at least three years. The authors also report the preliminary results obtained with passive immunotherapy in twenty-six patients with chronic osteomyelitis that had proved resistant to all other forms of treatment. Sero-immunological investigations in these patients revealed a deficiency in the opsonifying capacity of the serum. Treatment with opsonin precursors produced complete recession of symptoms and clinical signs, maintained for at least a year, in 50 per cent of these patients.

Adolescent↗
PubMed1981

Adamantinoma of the long bones. The experience at the Istituto Ortopedico Rizzoli.

All cases of adamantinoma seen at the Istituto Ortopedico Rizzoli were retrospectively reviewed. Although this tumor is exceedingly rare, nine cases were collected. The tumor is composed of four histological patterns: spindle, basaloid, squamoid, and tubular. The prognosis of this tumor depends on the adequacy of therapy. Surgery that is expedient and adequate tends to offer the best prognosis.

Adolescent↗
PubMed1981

Malignant tumours of the bones of the hand (from the records of the Rizzoli Institute).

The authors present ten cases of malignant neoplasm of the bones of the hand, four primary tumours and six solitary metastatic tumours, from the case material of the Rizzoli Institute. They stress the importance of differential diagnosis of these rare neoplasms, in particular from benign neoplastic or hyperplastic lesions, which are common in the hand.

Adolescent↗
PubMed1981

Soft tissue sarcoma of the hand.

The authors report twelve cases of soft tissue sarcoma distal to the flexor crease of the wrist. These were isolated from a total of 414 cases of soft tissue sarcoma treated at the Rizzoli Institute. This case material comprises three epitheloid sarcomas, four fibrosarcomas, two rhabdomyosarcomas, one synovial sarcoma, one myxoid malignant fibrous histiocytoma, and one myxoid chondrosarcoma. The authors deal in detail with the biological behaviour, the criteria of differential diagnosis, and the indications for treatment in each histological type of sarcoma.

Adolescent↗
PubMed1981

Osteofibrous dysplasia of the tibia and fibula.

Osteofibrous dysplasia of the tibia and fibula is not a well recognized entity. We have seen thirty-five patients with the disease. Twenty-two comparable cases have been reported in the literature with such diagnoses as ossifying fibroma, congenital fibrous dysplasia, and congenital fibrous defect of the tibia. The main differential diagnosis is with fibrous dysplasia and with adamantinoma of a long bone. Twelve of our patients had long-term follow-up and some of the lesions regressed spontaneously. Osteofibrous dysplasia seldom has even a moderate tendency to progress during childhood, but it recurs frequently after curettage or subperiosteal resection. Such recurrences generally are moderately progressive or not progressive at all. Any progression of the lesion comes to an end after puberty. Attempts at radical surgery either primarily or after recurrence do not seem to be necessary. Surgery should be delayed as long as possible and should be restricted to extensive lesions. The results of surgical treatment usually are good even in patients with a recurrence, fracture, or pseudarthrosis.

Ameloblastoma↗
PubMed1980

Local recurrence after amputation for osteosarcoma.

Two hundred and forty-eight high-grade central osteosarcomata were treated by amputation or disarticulation; in 5.2 per cent the tumour recurred at the amputation site. The following causes may be responsible for local recurrence: the level of the amputation is too close to the tumour; there is an unrecognised intramedullary extension of the tumour; during a previous block resection tumour cells may have been seeded in the soft tissues; the primary tumour was too extensive even for radical surgery; "skip" metastases may have been present; iatrogenic tumour implantation may have occurred while a biopsy was being performed during the course of an amputation. Treatment of the primary osteosarcoma should take all these possibilities into account. In our experience adjuvant chemotherapy has not significantly changed the frequency of local recurrences which should be treated by radical operation or, if this is not possible, by irradiation; chemotherapy may be used as an adjuvant. The prognosis of local recurrences is bad.

Adolescent↗
PubMed1980

Multicentric osteosarcoma.

A case of multicentric osteosarcoma is described. This is a rare variety of osteosarcoma, characterised by multiple simultaneous neoplastic bone lesions, of a radiographically sclerosing type, which precede the appearance of the pulmonary metastases. The pathological and clinical features are discussed and comparisons made with similar cases reported in the literature. The therapeutic management of this variety of osteosarcoma is outlined. The cases so far reported have always proved fatal, with a mean survival time of eight months from time of diagnosis.

Adult↗